HGS and RHOBTB3

Number of citations of the paper that reports this interaction (PMID 19019082)
2

Data Source:
BioGRID (pull down)

		HGS	RHOBTB3
Gene Name		hepatocyte growth factor-regulated tyrosine kinase substrate	Rho-related BTB domain containing 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Secretory Granule Early Endosome Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Golgi Apparatus Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Domain Specific Binding Metal Ion Binding	Protein Binding ATP Binding GTP Binding ATPase Activity Rab GTPase Binding
	Biological Process	Protein Targeting To Lysosome Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Endosome To Lysosome Transport Membrane Invagination Positive Regulation Of Gene Expression Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion	Small GTPase Mediated Signal Transduction Metabolic Process Retrograde Transport, Endosome To Golgi
Pathways		Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS		Eye color traits ( 20463881)
Protein-Protein Interactions		138 interactors: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG CASK CBS CCDC103 CCDC114 CCDC33 CEP55 CEP57L1 CLTC CRMP1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DGCR6 DLG4 EGFR EHMT2 EPS15 ESRRG EXOC7 EXOC8 GFAP GFI1B GGA2 GKAP1 HAP1 HNRNPDL HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KRT6A LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD4L NF2 NMI NPAS2 NUP54 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 POGZ PPP1R16A PPP1R7 PTCD3 RHOBTB3 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 STAM STAM2 STXBP1 SUMO1 SUN2 TADA2A TIMMDC1 TJP2 TMCC2 TOM1L1 TRAK1 TRAP1 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37C VPS37D ZNF302	9 interactors: BHLHE40 CCNE1 CUL3 HGS RAB9A RBPMS RBX1 RHOBTB2 UBXN11
Entrez ID		9146	22836
HPRD ID		05085	09557
Ensembl ID		ENSG00000185359	ENSG00000164292
Uniprot IDs		O14964	O94955
PDB IDs		2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?		Establishment Of Localization In Cell Cellular Localization Viral Protein Processing Protein Localization Intracellular Transport Membrane Organization Endosomal Transport Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Regulation Of ERBB Signaling Pathway Virion Assembly Intracellular Transport Of Virus Viral Process Cellular Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Viral Life Cycle Cell Cycle Process Organelle Organization Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Mitotic Cell Cycle Process Transport Post-Golgi Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Gene Expression Cell Cycle Vesicle Organization Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cellular Process Cellular Response To Transforming Growth Factor Beta Stimulus Posttranscriptional Regulation Of Gene Expression Secretion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process JNK Cascade Response To Organic Substance	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Monoubiquitination Positive Regulation Of Exocytosis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Trophectodermal Cellular Morphogenesis Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Exocytosis G1/S Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Transport Negative Regulation Of Wnt Signaling Pathway Endosomal Transport Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Signaling Regulation Of Canonical Wnt Signaling Pathway Cellular Macromolecule Catabolic Process Protein Neddylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Wnt Signaling Pathway Embryonic Cleavage Signal Transduction Positive Regulation Of SMAD Protein Import Into Nucleus Protein Localization To Lysosome Stress Fiber Assembly Regulation Of Wnt Signaling Pathway Regulation Of Cellular Localization Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Chromosome Segregation Positive Regulation Of Secretion Negative Regulation Of Signal Transduction Regulation Of SMAD Protein Import Into Nucleus Membrane Invagination COPII Vesicle Coating Signaling Negative Regulation Of Signaling Cell Communication Regulation Of Vesicle-mediated Transport Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein Targeting To Vacuole
Tagcloud ?		adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y	apparatus atypical cartilage embryo endosomes expresses galactosidase golgi gtpases histochemical investigating lacz localizes northern organism pave persists preliminary seminiferous testicular testis trafficking tubules tunica ubiquitous ubiquitously uterus vesicle
Tagcloud (Difference) ?		adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y	apparatus atypical cartilage embryo endosomes expresses galactosidase golgi gtpases histochemical investigating lacz localizes northern organism pave persists preliminary seminiferous testicular testis trafficking tubules tunica ubiquitous ubiquitously uterus vesicle
Tagcloud (Intersection) ?