HGS and MAT2A

Number of citations of the paper that reports this interaction (PubMedID 19019082)
84

Data Source:
BioGRID (pull down)

		HGS	MAT2A
Description		hepatocyte growth factor-regulated tyrosine kinase substrate	methionine adenosyltransferase 2A
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Multivesicular Body Membrane ESCRT-0 Complex Extracellular Exosome Phagocytic Vesicle Lumen	Cytosol Methionine Adenosyltransferase Complex
	Molecular Function	Protein Binding Zinc Ion Binding Protein Domain Specific Binding Phosphatidylinositol Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding	Nucleotide Binding Methionine Adenosyltransferase Activity Protein Binding ATP Binding Transferase Activity Small Molecule Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Targeting To Lysosome Signal Transduction Negative Regulation Of Cell Population Proliferation Membrane Invagination Positive Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Transport Endosomal Transport Macroautophagy Negative Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Receptor Internalization Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Localization To Membrane Membrane Fission Positive Regulation Of Exosomal Secretion	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Protein-containing Complex Localization Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Protein Hexamerization TORC1 Signaling Protein Complex Oligomerization Protein Heterooligomerization Cellular Response To Methionine Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Leukemia Inhibitory Factor
Pathways		EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle	Methylation
Drugs		Citric acid	Ademetionine
Diseases
GWAS		Eye color traits ( 20463881) Refractive error ( 32231278)	Coronary artery disease ( 29212778) Dysmenorrheic pain ( 27454463) Myocardial infarction ( 33532862) Urinary albumin excretion ( 30220432)
Interacting Genes		328 interacting genes: ABI2 ACLY ACOT11 ACTN3 ADRA2C AHCYL1 AKAP8L ANKRD55 ANTKMT APC APLP2 APP ARFIP2 ARL6IP1 ARMC7 ASB12 ATN1 ATP1A1 ATP2A2 ATXN1L BBC3 BCAS2 BEGAIN BFSP2 BICRAL BLOC1S1 BORCS6 BRINP3 BSG C1orf94 C20orf173 C3orf36 CASK CBS CCDC136 CCDC196 CCDC33 CCND3 CDR2 CDSN CEACAM6 CEP55 CEP57L1 CEP63 CEP68 CFAP68 CIMIP2A CLTC COG8 CRMP1 CRX CSNK2A1 CSTF2 CSTF2T CTTNBP2NL CYB5R2 DAAM2 DAZAP2 DCTN2 DECR1 DEUP1 DGCR6 DLG4 DNAAF19 DSN1 DTX2 DYDC1 EFHC2 EGFL7 EGFR EHMT2 EIF3F EPS15 ESRRG EXOC3L1 EXOC5 EXOC7 EXOC8 EYA2 FAM168A FAM185A FANCG FBN1 FCHSD2 FIGN FLOT1 FLOT2 FNDC11 FOXD4L1 FOXI1 FSD2 FTCD GATC GFAP GFI1B GGA2 GKAP1 GOLGA2 GOLGA6L9 GOLGA7B GUCA1C HAP1 HAUS1 HNRNPDL HNRNPM HSF4 HSFY1 HSPA8 ICA1L IFNA16 IFT74 IL2RB IL4R ILKAP ING5 INTS4 IPO4 JAKMIP2 JMJD7 KIAA0753 KIAA0825 KLF4 KRT13 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT26 KRT27 KRT3 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT6A KRT75 KRT76 KRT82 KRT86 KRTAP19-5 KRTAP26-1 KRTAP7-1 LASP1 LDOC1 LINC00265 LITAF LMO1 LMO4 LRRC61 LURAP1 LYST MAGEB4 MAGED1 MAP3K1 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED21 MED22 MED25 MED30 MED4 MED7 MEIS3 MEST MET METTL27 MIF4GD MKNK1 MKRN3 MRFAP1L1 MTHFD1L NADSYN1 NDC80 NDUFB10 NEDD4 NEDD8 NEFL NF2 NFYC NMI NPAS2 NUP54 NUP62 NUTM2F ODAM OIP5 OSBPL5 P4HA3 PAK1 PAX5 PAX6 PEF1 PELP1 PFKM PIK3R1 PITX1 PKNOX2 PLA2G10 PLAAT1 PLCD1 PLD3 PLEKHB2 PMEPA1 PNMA1 POGZ POU2AF1 POU6F2 PPP1R16A PPP1R7 PPP2R3B PRR22 PRR5 PSMB11 PSMB4 PTCD3 RASSF4 RBCK1 RFC2 RFX6 RHOBTB3 RINT1 RNF4 RPRD1A RPS3A RSPO4 RSU1 RUNX1 SAPCD1 SAXO4 SCAMP3 SCRN1 SCT SDS SERGEF SERTAD3 SF3B3 SHANK3 SMAD2 SMAD3 SMAD5 SMARCB1 SNAP25 SNX1 SNX5 SNX7 SORBS3 SPATA12 SPC25 SPIRE2 SPMIP6 SS18L1 STAM STAM2 STK32C STMN3 STX11 STXBP1 SUMO1 SUN2 SYK TADA2A TASOR2 TBX19 TCP11L2 TEKT1 TEKT5 TFG TIMM10B TIMMDC1 TJP2 TLE5 TMCC2 TOM1L1 TP53BP1 TRAF1 TRAF4 TRAK1 TRAP1 TRIM10 TRIM17 TRIM23 TRIM27 TRIM54 TRIM69 TRIM73 TRIML2 TSC1 TSG101 TUBB TUBB2A UBA1 UBA52 UBAP2 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 UBQLNL UBXN11 USHBP1 USP54 VGLL3 VMP1 VPS37A VPS37B VPS37C VPS37D VPS52 WASHC1 WWP2 YPEL3 ZNF302 ZNF34 ZNF430 ZNF44	10 interacting genes: CEBPA CUL3 DSCAM HGS MAT1A MAT2B OGT PRC1 TMEM213 UBE2I
Entrez ID		9146	4144
HPRD ID		05085	03275
Ensembl ID		ENSG00000185359	ENSG00000168906
Uniprot IDs		A0A0S2Z4R4 O14964	A0A140VJP5 P31153
PDB IDs		2D3G 3F1I 3OBQ 3ZYQ 4AVX	2P02 4KTT 4KTV 4NDN 5A19 5A1G 5A1I 5UGH 6FAJ 6FBN 6FBO 6FBP 6FCB 6FCD 6FWB 6G6R 6P9V 6WKB 7BHR 7BHS 7BHT 7BHU 7BHV 7BHW 7BHX 7KCC 7KCE 7KCF 7KDA 7KDB 7L1A 7LNH 7RW5 7RW7 7RWG 7RWH 7RXV 7RXW 7RXX 8AXZ 8OOG 8P1T 8P1V 8P1W 8P4H 8QDY 8QDZ 8QE0 8QE1 8QE2 8QE3 8XAM 8XAR 8XB0 8XJ2
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament Protein Binding Structural Molecule Activity Organelle Organization Epithelial Cell Differentiation Supramolecular Fiber Organization Cytoskeleton Organization Cytoskeleton Morphogenesis Of An Epithelium Tissue Morphogenesis Anatomical Structure Morphogenesis Cellular Localization Cytosol Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission Ubiquitin Protein Ligase Binding Intracellular Transport Intracellular Protein Localization Establishment Of Protein Localization Axonemal A Tubule Inner Sheath Microtubule-based Process Protein Transport Establishment Of Protein Localization To Vacuole Structural Constituent Of Cytoskeleton Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Ubiquitin Binding Establishment Of Localization In Cell Endosome Transport Via Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway ESCRT I Complex Protein Localization To Vacuole Multivesicular Body Assembly Multivesicular Body Organization Endosomal Transport Endosome Membrane Multivesicular Body Sorting Pathway Identical Protein Binding Epidermis Development Modification-dependent Protein Catabolic Process Late Endosome To Vacuole Transport Viral Budding Protein Tag Activity Core Mediator Complex Exocyst Organelle Localization	Methionine Adenosyltransferase Complex S-adenosylmethionine Biosynthetic Process S-adenosylmethionine Metabolic Process Cellular Component Assembly One-carbon Metabolic Process Chromatin DNA Binding Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding L-methionine Catabolic Process Methionine Adenosyltransferase Activity SUMO Conjugating Enzyme Activity Trophectodermal Cellular Morphogenesis Liver Morphogenesis Positive Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling Regulation Of Cytokinesis Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Mitotic Spindle Elongation Methionine Adenosyltransferase Regulator Activity Protein Localization To Vacuole CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Sulfur Compound Biosynthetic Process RING-like Zinc Finger Domain Binding Regulation Protein Catabolic Process At Postsynapse Regulation Of TORC1 Signaling Protein O-acetylglucosaminyltransferase Activity ESCRT-0 Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Phenylpropanoid Response To Nutrient Levels Positive Regulation Of Gene Expression Inflammatory Response Response To Nutrient White Fat Cell Proliferation Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Phosphorus Metabolic Process Catabolic Process SUMO Ligase Complex Small Protein Activating Enzyme Binding Cell Division
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