HGS and RSU1

Number of citations of the paper that reports this interaction (PMID 19019082)
2

Data Source:
BioGRID (pull down)

		HGS	RSU1
Gene Name		hepatocyte growth factor-regulated tyrosine kinase substrate	Ras suppressor protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Secretory Granule Early Endosome Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Cytosol Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Domain Specific Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein Targeting To Lysosome Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Endosome To Lysosome Transport Membrane Invagination Positive Regulation Of Gene Expression Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion	Signal Transduction Ras Protein Signal Transduction Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell-substrate Adhesion Cell Junction Assembly Positive Regulation Of GTPase Activity Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Eye color traits ( 20463881)	Obesity-related traits ( 23251661) Urinary albumin excretion ( 21355061)
Protein-Protein Interactions		138 interactors: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG CASK CBS CCDC103 CCDC114 CCDC33 CEP55 CEP57L1 CLTC CRMP1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DGCR6 DLG4 EGFR EHMT2 EPS15 ESRRG EXOC7 EXOC8 GFAP GFI1B GGA2 GKAP1 HAP1 HNRNPDL HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KRT6A LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD4L NF2 NMI NPAS2 NUP54 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 POGZ PPP1R16A PPP1R7 PTCD3 RHOBTB3 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 STAM STAM2 STXBP1 SUMO1 SUN2 TADA2A TIMMDC1 TJP2 TMCC2 TOM1L1 TRAK1 TRAP1 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37C VPS37D ZNF302	5 interactors: APP GSK3B HGS LIMS1 RAF1
Entrez ID		9146	6251
HPRD ID		05085	01551
Ensembl ID		ENSG00000185359	ENSG00000148484
Uniprot IDs		O14964	Q15404
PDB IDs		2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?		Establishment Of Localization In Cell Cellular Localization Viral Protein Processing Protein Localization Intracellular Transport Membrane Organization Endosomal Transport Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Regulation Of ERBB Signaling Pathway Virion Assembly Intracellular Transport Of Virus Viral Process Cellular Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Viral Life Cycle Cell Cycle Process Organelle Organization Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Mitotic Cell Cycle Process Transport Post-Golgi Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Gene Expression Cell Cycle Vesicle Organization Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cellular Process Cellular Response To Transforming Growth Factor Beta Stimulus Posttranscriptional Regulation Of Gene Expression Secretion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process JNK Cascade Response To Organic Substance	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Regulation Of Cellular Ketone Metabolic Process Regulation Of Cell Differentiation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Axonogenesis Regulation Of ERBB Signaling Pathway Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Response To Growth Factor Neuron Projection Morphogenesis Regulation Of Peptidyl-serine Phosphorylation Extrinsic Apoptotic Signaling Pathway Death-inducing Signaling Complex Assembly Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Proliferation Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Complex Assembly Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Innate Immune Response Regulation Of Protein Binding Negative Regulation Of Cellular Protein Metabolic Process Neuron Projection Development Negative Regulation Of Type B Pancreatic Cell Development Synaptic Growth At Neuromuscular Junction Superior Temporal Gyrus Development Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?		adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y	anxa4 cacybp cfl1 ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Difference) ?		adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y	anxa4 cacybp cfl1 ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Intersection) ?