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HGS and TRIM17
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
HGS
TRIM17
Description
hepatocyte growth factor-regulated tyrosine kinase substrate
tripartite motif containing 17
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Lysosome
Endosome
Early Endosome
Cytosol
Membrane
Early Endosome Membrane
Multivesicular Body Membrane
ESCRT-0 Complex
Extracellular Exosome
Phagocytic Vesicle Lumen
Cytoplasm
Lysosome
Molecular Function
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Phosphatidylinositol Binding
Ubiquitin Binding
Ubiquitin-like Protein Ligase Binding
Metal Ion Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Protein-macromolecule Adaptor Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Protein Targeting To Lysosome
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Membrane Invagination
Positive Regulation Of Gene Expression
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Protein Transport
Endosomal Transport
Macroautophagy
Negative Regulation Of Angiogenesis
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Receptor Internalization
Endocytic Recycling
Multivesicular Body Assembly
Regulation Of Protein Catabolic Process
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Regulation Of MAP Kinase Activity
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Protein Localization To Membrane
Membrane Fission
Positive Regulation Of Exosomal Secretion
Autophagy
Regulation Of Gene Expression
Protein Ubiquitination
Regulation Of Protein Localization
Innate Immune Response
Protein Autoubiquitination
Pathways
EGFR downregulation
Lysosome Vesicle Biogenesis
Ub-specific processing proteases
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
RHOU GTPase cycle
Endosomal Sorting Complex Required For Transport (ESCRT)
Inhibition of membrane repair
Prevention of phagosomal-lysosomal fusion
RHOBTB3 ATPase cycle
Interferon gamma signaling
Drugs
Citric acid
Diseases
GWAS
Eye color traits (
20463881
)
Refractive error (
32231278
)
Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy (
30066433
)
Interacting Genes
328 interacting genes:
ABI2
ACLY
ACOT11
ACTN3
ADRA2C
AHCYL1
AKAP8L
ANKRD55
ANTKMT
APC
APLP2
APP
ARFIP2
ARL6IP1
ARMC7
ASB12
ATN1
ATP1A1
ATP2A2
ATXN1L
BBC3
BCAS2
BEGAIN
BFSP2
BICRAL
BLOC1S1
BORCS6
BRINP3
BSG
C1orf94
C20orf173
C3orf36
CASK
CBS
CCDC136
CCDC196
CCDC33
CCND3
CDR2
CDSN
CEACAM6
CEP55
CEP57L1
CEP63
CEP68
CFAP68
CIMIP2A
CLTC
COG8
CRMP1
CRX
CSNK2A1
CSTF2
CSTF2T
CTTNBP2NL
CYB5R2
DAAM2
DAZAP2
DCTN2
DECR1
DEUP1
DGCR6
DLG4
DNAAF19
DSN1
DTX2
DYDC1
EFHC2
EGFL7
EGFR
EHMT2
EIF3F
EPS15
ESRRG
EXOC3L1
EXOC5
EXOC7
EXOC8
EYA2
FAM168A
FAM185A
FANCG
FBN1
FCHSD2
FIGN
FLOT1
FLOT2
FNDC11
FOXD4L1
FOXI1
FSD2
FTCD
GATC
GFAP
GFI1B
GGA2
GKAP1
GOLGA2
GOLGA6L9
GOLGA7B
GUCA1C
HAP1
HAUS1
HNRNPDL
HNRNPM
HSF4
HSFY1
HSPA8
ICA1L
IFNA16
IFT74
IL2RB
IL4R
ILKAP
ING5
INTS4
IPO4
JAKMIP2
JMJD7
KIAA0753
KIAA0825
KLF4
KRT13
KRT14
KRT15
KRT16
KRT18
KRT19
KRT24
KRT25
KRT26
KRT27
KRT3
KRT31
KRT33B
KRT34
KRT35
KRT36
KRT37
KRT38
KRT39
KRT40
KRT6A
KRT75
KRT76
KRT82
KRT86
KRTAP19-5
KRTAP26-1
KRTAP7-1
LASP1
LDOC1
LINC00265
LITAF
LMO1
LMO4
LRRC61
LURAP1
LYST
MAGEB4
MAGED1
MAP3K1
MAP3K10
MAP3K7
MAPK1IP1L
MARK4
MAT2A
MED21
MED22
MED25
MED30
MED4
MED7
MEIS3
MEST
MET
METTL27
MIF4GD
MKNK1
MKRN3
MRFAP1L1
MTHFD1L
NADSYN1
NDC80
NDUFB10
NEDD4
NEDD8
NEFL
NF2
NFYC
NMI
NPAS2
NUP54
NUP62
NUTM2F
ODAM
OIP5
OSBPL5
P4HA3
PAK1
PAX5
PAX6
PEF1
PELP1
PFKM
PIK3R1
PITX1
PKNOX2
PLA2G10
PLAAT1
PLCD1
PLD3
PLEKHB2
PMEPA1
PNMA1
POGZ
POU2AF1
POU6F2
PPP1R16A
PPP1R7
PPP2R3B
PRR22
PRR5
PSMB11
PSMB4
PTCD3
RASSF4
RBCK1
RFC2
RFX6
RHOBTB3
RINT1
RNF4
RPRD1A
RPS3A
RSPO4
RSU1
RUNX1
SAPCD1
SAXO4
SCAMP3
SCRN1
SCT
SDS
SERGEF
SERTAD3
SF3B3
SHANK3
SMAD2
SMAD3
SMAD5
SMARCB1
SNAP25
SNX1
SNX5
SNX7
SORBS3
SPATA12
SPC25
SPIRE2
SPMIP6
SS18L1
STAM
STAM2
STK32C
STMN3
STX11
STXBP1
SUMO1
SUN2
SYK
TADA2A
TASOR2
TBX19
TCP11L2
TEKT1
TEKT5
TFG
TIMM10B
TIMMDC1
TJP2
TLE5
TMCC2
TOM1L1
TP53BP1
TRAF1
TRAF4
TRAK1
TRAP1
TRIM10
TRIM17
TRIM23
TRIM27
TRIM54
TRIM69
TRIM73
TRIML2
TSC1
TSG101
TUBB
TUBB2A
UBA1
UBA52
UBAP2
UBB
UBC
UBE2I
UBE4B
UBQLN1
UBQLN4
UBQLNL
UBXN11
USHBP1
USP54
VGLL3
VMP1
VPS37A
VPS37B
VPS37C
VPS37D
VPS52
WASHC1
WWP2
YPEL3
ZNF302
ZNF34
ZNF430
ZNF44
20 interacting genes:
BAX
HGS
LGALS3
LGALS8
LRSAM1
MEOX2
MNAT1
TRAF6
TRIM39
TRIM41
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2H
UBE2N
UBE2W
USP15
Entrez ID
9146
51127
HPRD ID
05085
05839
Ensembl ID
ENSG00000185359
ENSG00000162931
Uniprot IDs
A0A0S2Z4R4
O14964
B3KP04
Q9Y577
PDB IDs
2D3G
3F1I
3OBQ
3ZYQ
4AVX
Enriched GO Terms of Interacting Partners
?
Intermediate Filament Organization
Structural Constituent Of Skin Epidermis
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Keratin Filament
Intermediate Filament
Protein Binding
Structural Molecule Activity
Organelle Organization
Epithelial Cell Differentiation
Supramolecular Fiber Organization
Cytoskeleton Organization
Cytoskeleton
Morphogenesis Of An Epithelium
Tissue Morphogenesis
Anatomical Structure Morphogenesis
Cellular Localization
Cytosol
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Membrane Fission
Ubiquitin Protein Ligase Binding
Intracellular Transport
Intracellular Protein Localization
Establishment Of Protein Localization
Axonemal A Tubule Inner Sheath
Microtubule-based Process
Protein Transport
Establishment Of Protein Localization To Vacuole
Structural Constituent Of Cytoskeleton
Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
Ubiquitin Binding
Establishment Of Localization In Cell
Endosome Transport Via Multivesicular Body Sorting Pathway
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
ESCRT I Complex
Protein Localization To Vacuole
Multivesicular Body Assembly
Multivesicular Body Organization
Endosomal Transport
Endosome Membrane
Multivesicular Body Sorting Pathway
Identical Protein Binding
Epidermis Development
Modification-dependent Protein Catabolic Process
Late Endosome To Vacuole Transport
Viral Budding
Protein Tag Activity
Core Mediator Complex
Exocyst
Organelle Localization
Ubiquitin Conjugating Enzyme Activity
Protein Ubiquitination
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Ubiquitin-protein Transferase Activity
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Protein Modification Process
Protein Monoubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Transferase Activity
Macromolecule Catabolic Process
Ubiquitin Protein Ligase Activity
Ubiquitin-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Catabolic Process
Protein Metabolic Process
Proteolysis
Negative Regulation Of Signal Transduction
Protein Autoubiquitination
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Macromolecule Metabolic Process
Response To Virus
Cytosol
Nucleus
DNA Damage Response
Response To Other Organism
Protein Catabolic Process
TORC1 Signaling
Negative Regulation Of TORC1 Signaling
Response To External Biotic Stimulus
Innate Immune Response
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K63-linked Ubiquitination
ATP Binding
Positive Regulation Of Immune System Process
Antiviral Innate Immune Response
TOR Signaling
Defense Response To Symbiont
Negative Regulation Of TOR Signaling
Regulation Of Signal Transduction
Defense Response To Other Organism
Proteasomal Protein Catabolic Process
Regulation Of TORC1 Signaling
Positive Regulation Of Protein Polyubiquitination
Positive Regulation Of Protein Ubiquitination
Defense Response To Virus
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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