HGS and EYA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HGS	EYA2
Description		hepatocyte growth factor-regulated tyrosine kinase substrate	EYA transcriptional coactivator and phosphatase 2
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Multivesicular Body Membrane ESCRT-0 Complex Extracellular Exosome Phagocytic Vesicle Lumen	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Protein Domain Specific Binding Phosphatidylinositol Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding	Magnesium Ion Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Histone H2AXY142 Phosphatase Activity
	Biological Process	Protein Targeting To Lysosome Signal Transduction Negative Regulation Of Cell Population Proliferation Membrane Invagination Positive Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Transport Endosomal Transport Macroautophagy Negative Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Receptor Internalization Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Localization To Membrane Membrane Fission Positive Regulation Of Exosomal Secretion	DNA Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Mesodermal Cell Fate Specification Striated Muscle Tissue Development Cell Differentiation Positive Regulation Of DNA Repair Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs		Citric acid
Diseases
GWAS		Eye color traits ( 20463881) Refractive error ( 32231278)	A body shape index ( 34021172) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 31361310) Asthma ( 32296059) Body fat percentage and triglycerides (pairwise) ( 33619380) Brain volume in infants (intracranial brain volume) ( 28763065) Coffee consumption ( 31046077) Fasting insulin ( 34059833) FEV1 ( 30804560) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Lung function (FVC) ( 30804560 30061609) Non-del(5q) myelodysplastic syndromes ( 31738830) Peak expiratory flow ( 30804560) Reticulocyte count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels ( 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 30054458 30297969) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		328 interacting genes: ABI2 ACLY ACOT11 ACTN3 ADRA2C AHCYL1 AKAP8L ANKRD55 ANTKMT APC APLP2 APP ARFIP2 ARL6IP1 ARMC7 ASB12 ATN1 ATP1A1 ATP2A2 ATXN1L BBC3 BCAS2 BEGAIN BFSP2 BICRAL BLOC1S1 BORCS6 BRINP3 BSG C1orf94 C20orf173 C3orf36 CASK CBS CCDC136 CCDC196 CCDC33 CCND3 CDR2 CDSN CEACAM6 CEP55 CEP57L1 CEP63 CEP68 CFAP68 CIMIP2A CLTC COG8 CRMP1 CRX CSNK2A1 CSTF2 CSTF2T CTTNBP2NL CYB5R2 DAAM2 DAZAP2 DCTN2 DECR1 DEUP1 DGCR6 DLG4 DNAAF19 DSN1 DTX2 DYDC1 EFHC2 EGFL7 EGFR EHMT2 EIF3F EPS15 ESRRG EXOC3L1 EXOC5 EXOC7 EXOC8 EYA2 FAM168A FAM185A FANCG FBN1 FCHSD2 FIGN FLOT1 FLOT2 FNDC11 FOXD4L1 FOXI1 FSD2 FTCD GATC GFAP GFI1B GGA2 GKAP1 GOLGA2 GOLGA6L9 GOLGA7B GUCA1C HAP1 HAUS1 HNRNPDL HNRNPM HSF4 HSFY1 HSPA8 ICA1L IFNA16 IFT74 IL2RB IL4R ILKAP ING5 INTS4 IPO4 JAKMIP2 JMJD7 KIAA0753 KIAA0825 KLF4 KRT13 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT26 KRT27 KRT3 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT6A KRT75 KRT76 KRT82 KRT86 KRTAP19-5 KRTAP26-1 KRTAP7-1 LASP1 LDOC1 LINC00265 LITAF LMO1 LMO4 LRRC61 LURAP1 LYST MAGEB4 MAGED1 MAP3K1 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED21 MED22 MED25 MED30 MED4 MED7 MEIS3 MEST MET METTL27 MIF4GD MKNK1 MKRN3 MRFAP1L1 MTHFD1L NADSYN1 NDC80 NDUFB10 NEDD4 NEDD8 NEFL NF2 NFYC NMI NPAS2 NUP54 NUP62 NUTM2F ODAM OIP5 OSBPL5 P4HA3 PAK1 PAX5 PAX6 PEF1 PELP1 PFKM PIK3R1 PITX1 PKNOX2 PLA2G10 PLAAT1 PLCD1 PLD3 PLEKHB2 PMEPA1 PNMA1 POGZ POU2AF1 POU6F2 PPP1R16A PPP1R7 PPP2R3B PRR22 PRR5 PSMB11 PSMB4 PTCD3 RASSF4 RBCK1 RFC2 RFX6 RHOBTB3 RINT1 RNF4 RPRD1A RPS3A RSPO4 RSU1 RUNX1 SAPCD1 SAXO4 SCAMP3 SCRN1 SCT SDS SERGEF SERTAD3 SF3B3 SHANK3 SMAD2 SMAD3 SMAD5 SMARCB1 SNAP25 SNX1 SNX5 SNX7 SORBS3 SPATA12 SPC25 SPIRE2 SPMIP6 SS18L1 STAM STAM2 STK32C STMN3 STX11 STXBP1 SUMO1 SUN2 SYK TADA2A TASOR2 TBX19 TCP11L2 TEKT1 TEKT5 TFG TIMM10B TIMMDC1 TJP2 TLE5 TMCC2 TOM1L1 TP53BP1 TRAF1 TRAF4 TRAK1 TRAP1 TRIM10 TRIM17 TRIM23 TRIM27 TRIM54 TRIM69 TRIM73 TRIML2 TSC1 TSG101 TUBB TUBB2A UBA1 UBA52 UBAP2 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 UBQLNL UBXN11 USHBP1 USP54 VGLL3 VMP1 VPS37A VPS37B VPS37C VPS37D VPS52 WASHC1 WWP2 YPEL3 ZNF302 ZNF34 ZNF430 ZNF44	36 interacting genes: AATK ATOSB BAG3 CATSPER1 CDK18 DMRTB1 DTX2 DUSP21 ENKD1 FBXO7 GNAI2 GNAZ HGS IQUB LGALS4 MED25 PATZ1 PAX9 PIN1 POGZ RBPMS RFX2 ROR2 SIX1 SIX4 SNRPC SPG21 SUOX TEKT4 TEKT5 TFG TLE5 TRAF4 TRAPPC6A TSSK3 VPS37C
Entrez ID		9146	2139
HPRD ID		05085	09041
Ensembl ID		ENSG00000185359	ENSG00000064655
Uniprot IDs		A0A0S2Z4R4 O14964	E7ETN2 O00167
PDB IDs		2D3G 3F1I 3OBQ 3ZYQ 4AVX	3GEB 3HB0 3HB1 4EGC 5ZMA 7F8G 7F8H
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament Protein Binding Structural Molecule Activity Organelle Organization Epithelial Cell Differentiation Supramolecular Fiber Organization Cytoskeleton Organization Cytoskeleton Morphogenesis Of An Epithelium Tissue Morphogenesis Anatomical Structure Morphogenesis Cellular Localization Cytosol Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission Ubiquitin Protein Ligase Binding Intracellular Transport Intracellular Protein Localization Establishment Of Protein Localization Axonemal A Tubule Inner Sheath Microtubule-based Process Protein Transport Establishment Of Protein Localization To Vacuole Structural Constituent Of Cytoskeleton Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Ubiquitin Binding Establishment Of Localization In Cell Endosome Transport Via Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway ESCRT I Complex Protein Localization To Vacuole Multivesicular Body Assembly Multivesicular Body Organization Endosomal Transport Endosome Membrane Multivesicular Body Sorting Pathway Identical Protein Binding Epidermis Development Modification-dependent Protein Catabolic Process Late Endosome To Vacuole Transport Viral Budding Protein Tag Activity Core Mediator Complex Exocyst Organelle Localization	Sperm Flagellum Fungiform Papilla Morphogenesis Sperm Motility Motile Cilium Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Cellular Component Assembly Regulation Of Branch Elongation Involved In Ureteric Bud Branching Olfactory Placode Formation Organelle Assembly Axonemal A Tubule Inner Sheath Myotome Development Positive Regulation Of Ureteric Bud Formation Trigeminal Ganglion Development Cilium Cilium Movement Cranial Ganglion Development Tongue Development Metanephric Mesenchyme Development Positive Regulation Of Epithelial Tube Formation Microtubule-based Movement Regulation Of Synaptic Assembly At Neuromuscular Junction Cilium Assembly Microtubule-based Process Myoblast Migration Reproductive Process Cilium Organization Ciliary Basal Body Vesicle Organization Ganglion Development Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Guanyl Nucleotide Binding Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Animal Organ Morphogenesis Pharyngeal System Development Generation Of Neurons Plasma Membrane Bounded Cell Projection Assembly Regulation Of Branching Involved In Ureteric Bud Morphogenesis Protein Targeting G-protein Beta/gamma-subunit Complex Binding Cell Projection Assembly Regulation Of Skeletal Muscle Cell Differentiation COPII Vesicle Coating Muscle Cell Cellular Homeostasis Protein Binding Cell Motility Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Muscle Cell Migration Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
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