HGS and SUN2

Number of citations of the paper that reports this interaction (PMID 19019082)
2

Data Source:
BioGRID (pull down)

		HGS	SUN2
Gene Name		hepatocyte growth factor-regulated tyrosine kinase substrate	Sad1 and UNC84 domain containing 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Secretory Granule Early Endosome Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Nuclear Chromosome, Telomeric Region Condensed Nuclear Chromosome Nuclear Envelope Integral Component Of Nuclear Inner Membrane Endosome Membrane Nuclear Membrane LINC Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding Metal Ion Binding	Protein Binding Lamin Binding Microtubule Binding Identical Protein Binding
	Biological Process	Protein Targeting To Lysosome Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Endosome To Lysosome Transport Membrane Invagination Positive Regulation Of Gene Expression Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion	Nuclear Envelope Organization Mitotic Spindle Organization Nuclear Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization Cytoskeletal Anchoring At Nuclear Membrane Nuclear Matrix Anchoring At Nuclear Membrane
Pathways		Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	Meiotic synapsis
Drugs
Diseases
GWAS		Eye color traits ( 20463881)
Protein-Protein Interactions		138 interactors: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG CASK CBS CCDC103 CCDC114 CCDC33 CEP55 CEP57L1 CLTC CRMP1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DGCR6 DLG4 EGFR EHMT2 EPS15 ESRRG EXOC7 EXOC8 GFAP GFI1B GGA2 GKAP1 HAP1 HNRNPDL HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KRT6A LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD4L NF2 NMI NPAS2 NUP54 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 POGZ PPP1R16A PPP1R7 PTCD3 RHOBTB3 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 STAM STAM2 STXBP1 SUMO1 SUN2 TADA2A TIMMDC1 TJP2 TMCC2 TOM1L1 TRAK1 TRAP1 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37C VPS37D ZNF302	5 interactors: HGS NRM RAB5A RAB5B RPS20
Entrez ID		9146	25777
HPRD ID		05085	15611
Ensembl ID		ENSG00000185359	ENSG00000100242
Uniprot IDs		O14964	B4E2A6 J3KQE0 Q9UH99
PDB IDs		2D3G 3F1I 3OBQ 3ZYQ 4AVX	3UNP 4DXR 4DXS 4DXT 4FI9
Enriched GO Terms of Interacting Partners?		Establishment Of Localization In Cell Cellular Localization Viral Protein Processing Protein Localization Intracellular Transport Membrane Organization Endosomal Transport Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Regulation Of ERBB Signaling Pathway Virion Assembly Intracellular Transport Of Virus Viral Process Cellular Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Viral Life Cycle Cell Cycle Process Organelle Organization Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Mitotic Cell Cycle Process Transport Post-Golgi Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Gene Expression Cell Cycle Vesicle Organization Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cellular Process Cellular Response To Transforming Growth Factor Beta Stimulus Posttranscriptional Regulation Of Gene Expression Secretion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process JNK Cascade Response To Organic Substance	Cytoplasmic Transport Endosomal Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Cellular Protein Localization Rab Protein Signal Transduction Protein Transport Positive Regulation Of Exocytosis Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Regulation Of Exocytosis Cellular Localization Regulation Of Endocytosis Regulation Of Endosome Size Receptor Internalization Involved In Canonical Wnt Signaling Pathway Ras Protein Signal Transduction Plasma Membrane To Endosome Transport Positive Regulation Of Secretion Establishment Of Protein Localization To Organelle Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Localization To Membrane Protein Targeting To Lysosome Protein Localization To Lysosome Protein Targeting Cytoplasmic Translation Membrane Invagination Early Endosome To Late Endosome Transport Protein Localization To Organelle Protein Targeting To Vacuole Negative Regulation Of JAK-STAT Cascade Establishment Of Protein Localization To Vacuole Positive Regulation Of Smooth Muscle Cell Migration Endosome To Lysosome Transport Endosome Organization Small GTPase Mediated Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Secretion Regulation Of Synaptic Vesicle Exocytosis Synaptic Vesicle Recycling Transport Regulation Of Synaptic Vesicle Transport Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Transport Receptor Internalization Lysosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Filopodium Assembly
Tagcloud ?		adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y	arrangement c2c12 cardiomyopathy centrosomal connects dreifuss dystrophy edmd emery exemplified gross identifiable linc microtubule modifier muscular myonuclear myopathies myotubes ne nucleation pericentrin phenotypically positioning rearward recapitulated repositioning segregating sun1
Tagcloud (Difference) ?		adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y	arrangement c2c12 cardiomyopathy centrosomal connects dreifuss dystrophy edmd emery exemplified gross identifiable linc microtubule modifier muscular myonuclear myopathies myotubes ne nucleation pericentrin phenotypically positioning rearward recapitulated repositioning segregating sun1
Tagcloud (Intersection) ?