APH1A and PSENEN

Number of citations of the paper that reports this interaction (PMID 12740439)
126

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		APH1A	PSENEN
Gene Name		APH1A gamma secretase subunit	presenilin enhancer gamma secretase subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Golgi Cisterna Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Golgi Cisterna Membrane Gamma-secretase Complex
	Molecular Function	Endopeptidase Activity Protein Binding	Protein Binding
	Biological Process	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Apoptotic Signaling Pathway	Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Apoptotic Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants	Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ATF4 BHLHE40 GLP1R GPATCH8 HES1 HIVEP1 KLF11 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 THPO TLE1 TMED10	6 interactors: APH1A NCSTN PSEN1 PSEN2 THBD TMED10
Entrez ID		51107	55851
HPRD ID		06360	06362
Ensembl ID		ENSG00000117362
Uniprot IDs		B4DUG7 Q96BI3	Q9NZ42
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Notch Signaling Pathway Amyloid Precursor Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Membrane Protein Proteolysis Beta-amyloid Metabolic Process Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Metabolic Process Positive Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Neural Tube Patterning Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Protein Processing Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Neuron Development Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Programmed Cell Death Cell Morphogenesis Involved In Neuron Differentiation Cell Death Death Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Neuron Differentiation Response To Stimulus Response To Organic Substance Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Involved In Differentiation Cellular Response To Organic Substance Locomotion Peptide Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Transcription From RNA Polymerase II Promoter Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Dorsal/ventral Neural Tube Patterning Cellular Nitrogen Compound Metabolic Process Movement Of Cell Or Subcellular Component	Amyloid Precursor Protein Catabolic Process Amyloid Precursor Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Membrane Protein Proteolysis Beta-amyloid Metabolic Process Membrane Protein Intracellular Domain Proteolysis Notch Signaling Pathway Positive Regulation Of Coagulation Protein Processing Ephrin Receptor Signaling Pathway Locomotion Peptide Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Regulation Of Epidermal Growth Factor-activated Receptor Activity Neurotrophin TRK Receptor Signaling Pathway Response To External Stimulus Neurotrophin Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Amide Metabolic Process Dorsal/ventral Neural Tube Patterning T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Brain Morphogenesis Neuron Development Vesicle Targeting Apoptotic Process Leukocyte Cell-cell Adhesion Programmed Cell Death Homotypic Cell-cell Adhesion Cell Death Death Apoptotic Signaling Pathway Neuron Differentiation Thymus Development Neural Tube Patterning Response To Organic Substance Regulation Of Protein Tyrosine Kinase Activity Axon Guidance Lymphocyte Activation T Cell Activation Involved In Immune Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Somitogenesis Leukocyte Activation
Tagcloud ?		aph1b belonging categorize clarify cleave consequently exclusive fall gamma heterogeneous histopathological implying intensively kaplan meier mutually nicastrin pen presenilin probability probable proteolytically secretase transmembrane treatable triple ubiquitously univariate	ad al amyloidosis attenuates burden ca1 calorie cerebral cr endogenously enhancer feeding female hippocampal indicates influences intake involve libitum neuron pathology reduces reductions restriction secretase sustained tg2576 translatable
Tagcloud (Difference) ?		aph1b belonging categorize clarify cleave consequently exclusive fall gamma heterogeneous histopathological implying intensively kaplan meier mutually nicastrin pen probability probable proteolytically transmembrane treatable triple ubiquitously univariate	ad al amyloidosis attenuates burden ca1 calorie cerebral cr endogenously enhancer feeding female hippocampal indicates influences intake involve libitum neuron pathology reduces reductions restriction sustained tg2576 translatable
Tagcloud (Intersection) ?		presenilin secretase