APH1A and TMED10

Number of citations of the paper that reports this interaction (PMID 16641999)
75

Data Source:
HPRD (in vivo)

		APH1A	TMED10
Gene Name		APH1A gamma secretase subunit	transmembrane emp24-like trafficking protein 10 (yeast)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Golgi Cisterna Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Plasma Membrane Integral Component Of Membrane COPI-coated Vesicle Trans-Golgi Network Transport Vesicle Transport Vesicle Membrane Secretory Granule Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Zymogen Granule Membrane Extracellular Vesicular Exosome Gamma-secretase Complex
	Molecular Function	Endopeptidase Activity Protein Binding	Protein Binding Syntaxin Binding Protein Complex Binding
	Biological Process	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Apoptotic Signaling Pathway	Kidney Development Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Golgi Organization Cargo Loading Into Vesicle COPI-coated Vesicle Budding Response To Alkaloid Regulated Secretory Pathway Vesicle Targeting, To, From Or Within Golgi COPI Coating Of Golgi Vesicle COPII Vesicle Coating Protein Oligomerization Regulation Of Beta-amyloid Formation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS			Height ( 19343178)
Protein-Protein Interactions		15 interactors: ATF4 BHLHE40 GLP1R GPATCH8 HES1 HIVEP1 KLF11 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 THPO TLE1 TMED10	15 interactors: APH1A ARCN1 ARF1 COPA COPB1 COPB2 COPE COPG1 COPZ1 DHODH GORASP2 NCSTN PSENEN SEC23B TMED2
Entrez ID		51107	10972
HPRD ID		06360	12013
Ensembl ID		ENSG00000117362	ENSG00000170348
Uniprot IDs		B4DUG7 Q96BI3	B4DL12 P49755
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Notch Signaling Pathway Amyloid Precursor Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Membrane Protein Proteolysis Beta-amyloid Metabolic Process Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Metabolic Process Positive Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Neural Tube Patterning Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Protein Processing Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Neuron Development Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Programmed Cell Death Cell Morphogenesis Involved In Neuron Differentiation Cell Death Death Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Neuron Differentiation Response To Stimulus Response To Organic Substance Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Involved In Differentiation Cellular Response To Organic Substance Locomotion Peptide Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Transcription From RNA Polymerase II Promoter Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Dorsal/ventral Neural Tube Patterning Cellular Nitrogen Compound Metabolic Process Movement Of Cell Or Subcellular Component	COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Retrograde Vesicle-mediated Transport, Golgi To ER Membrane Budding Golgi Vesicle Transport Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Establishment Of Organelle Localization Organelle Localization Membrane Organization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Intracellular Protein Transport Protein Localization Intra-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Amyloid Precursor Protein Catabolic Process Membrane Protein Intracellular Domain Proteolysis Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Cellular Localization Notch Receptor Processing Cellular Protein Localization Membrane Protein Proteolysis Organelle Organization Transport Ephrin Receptor Signaling Pathway ER To Golgi Vesicle-mediated Transport Notch Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Protein Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cerebellar Purkinje Cell Layer Maturation Apoptotic Signaling Pathway Axon Guidance Cerebellum Maturation 'de Novo' UMP Biosynthetic Process Body Fluid Secretion Axonogenesis Establishment Of Golgi Localization
Tagcloud ?		aph1b belonging categorize clarify cleave consequently exclusive fall gamma heterogeneous histopathological implying intensively kaplan meier mutually nicastrin pen presenilin probability probable proteolytically secretase transmembrane treatable triple ubiquitously univariate	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmem70 y2h
Tagcloud (Difference) ?		aph1b belonging categorize clarify cleave consequently exclusive fall gamma heterogeneous histopathological implying intensively kaplan meier mutually nicastrin pen presenilin probability probable proteolytically secretase transmembrane treatable triple ubiquitously univariate	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmem70 y2h
Tagcloud (Intersection) ?