APH1A and GPATCH8

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		APH1A	GPATCH8
Gene Name		APH1A gamma secretase subunit	G patch domain containing 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Golgi Cisterna Membrane	Cellular_component
	Molecular Function	Endopeptidase Activity Protein Binding	Protein Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Apoptotic Signaling Pathway	Biological_process
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ATF4 BHLHE40 GLP1R GPATCH8 HES1 HIVEP1 KLF11 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 THPO TLE1 TMED10	4 interactors: APH1A ATXN1 ATXN1L NUMBL
Entrez ID		51107	23131
HPRD ID		06360	11089
Ensembl ID		ENSG00000117362
Uniprot IDs		B4DUG7 Q96BI3	Q9UKJ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Notch Signaling Pathway Amyloid Precursor Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Membrane Protein Proteolysis Beta-amyloid Metabolic Process Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Metabolic Process Positive Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Neural Tube Patterning Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Protein Processing Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Neuron Development Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Programmed Cell Death Cell Morphogenesis Involved In Neuron Differentiation Cell Death Death Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Neuron Differentiation Response To Stimulus Response To Organic Substance Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Involved In Differentiation Cellular Response To Organic Substance Locomotion Peptide Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Transcription From RNA Polymerase II Promoter Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Dorsal/ventral Neural Tube Patterning Cellular Nitrogen Compound Metabolic Process Movement Of Cell Or Subcellular Component	Lung Alveolus Development Organ Development Positive Regulation Of Hematopoietic Stem Cell Proliferation Lung Development Respiratory Tube Development Neuroblast Division In Subventricular Zone Respiratory System Development System Development Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Anatomical Structure Development Amyloid Precursor Protein Catabolic Process Forebrain Neuroblast Division Axonogenesis Membrane Protein Intracellular Domain Proteolysis Developmental Process Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Lateral Ventricle Development Notch Receptor Processing Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Somatic Stem Cell Division Tube Development Cell Morphogenesis Involved In Differentiation Membrane Protein Proteolysis Positive Regulation Of Dendrite Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Projection Development Stem Cell Division Ventricular System Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Proliferation In Forebrain Neuroblast Proliferation Neuron Development Positive Regulation Of Dendrite Development Visual Learning Visual Behavior Cell Morphogenesis Regulation Of Dendrite Morphogenesis Negative Regulation Of Transcription, DNA-templated Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription Neuron Differentiation Regulation Of Postsynaptic Membrane Potential
Tagcloud ?		aph1b belonging categorize clarify cleave consequently exclusive fall gamma heterogeneous histopathological implying intensively kaplan meier mutually nicastrin pen presenilin probability probable proteolytically secretase transmembrane treatable triple ubiquitously univariate
Tagcloud (Difference) ?		aph1b belonging categorize clarify cleave consequently exclusive fall gamma heterogeneous histopathological implying intensively kaplan meier mutually nicastrin pen presenilin probability probable proteolytically secretase transmembrane treatable triple ubiquitously univariate
Tagcloud (Intersection) ?