APH1A and THPO

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		APH1A	THPO
Description		aph-1A gamma-secretase subunit	thrombopoietin
Image
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Golgi Cisterna Membrane Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity	Signaling Receptor Binding Cytokine Activity Hormone Activity Growth Factor Activity
	Biological Process	Metanephros Development Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process	Positive Regulation Of Protein Phosphorylation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Megakaryocyte Differentiation Megakaryocyte Development Thrombopoietin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation	Platelet Aggregation (Plug Formation)
Drugs		E-2012 MK-0752
Diseases
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Morning vs. evening chronotype ( 26835600 26955885) Refractive error ( 32231278) Schizophrenia ( 25056061) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Cardiometabolic and hematological traits ( 27668658) Diisocyanate-induced asthma ( 25918132) Mean spheric corpuscular volume ( 32888494) Platelet count ( 20139978 22139419 27863252 29403010 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		36 interacting genes: ANKRD46 APOD ASGR1 ATF4 BHLHE40 CREB3 DRD2 FIS1 FXYD6 GLP1R GPATCH8 GPR35 HES1 HIVEP1 IGFBP5 KLF11 LAT MFSD6 MPP1 MRAP2 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 SCAND1 SERP1 SLC38A7 SLC39A9 SMAGP THPO TLE1 TMED10 TMEM140 TMEM218 TRARG1	6 interacting genes: APH1A EP300 MPL NUMBL S100A6 S100P
Entrez ID		51107	7066
HPRD ID		06360	02500
Ensembl ID		ENSG00000117362	ENSG00000090534
Uniprot IDs		B4DUG7 Q96BI3	A0A3B3ITS0 F8W6L1 P40225 Q5FBX8
PDB IDs		5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 7Y5T 7Y5X 7Y5Z 8IM7 8K8E 8KCO 8KCP 8KCS 8KCT 8KCU 8X52 8X53 8X54	1V7M 1V7N 8G04
Enriched GO Terms of Interacting Partners?		Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Amyloid Precursor Protein Metabolic Process Presynaptic Membrane Membrane Protein Proteolysis Notch Signaling Pathway Cajal-Retzius Cell Differentiation Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Cell Surface Receptor Signaling Pathway Growth Factor Receptor Binding Regulation Of Transport Adenohypophysis Development Positive Regulation Of Growth Hormone Secretion Membrane CAMP Response Element Binding Protein Binding Regulation Of Protein Metabolic Process Negative Regulation Of Transport Homeostatic Process Regulation Of Growth Hormone Secretion Membrane Protein Intracellular Domain Proteolysis Golgi Membrane Synaptic Membrane Endoplasmic Reticulum Unfolded Protein Response Circadian Regulation Of Gene Expression Cellular Response To Oxygen-containing Compound Signal Transduction Vesicle Targeting Epithelial Cell Proliferation Protein Processing Endopeptidase Activator Activity Regulation Of Primary Metabolic Process Regulation Of Synaptic Plasticity G Protein-coupled Dopamine Receptor Signaling Pathway Cerebral Cortex Neuron Differentiation	Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Platelet Formation Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Positive Regulation Of Cell Development Histone Crotonyltransferase Activity Basophil Homeostasis Thrombopoietin Receptor Activity Calcium-dependent Protein Binding Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Platelet Formation N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Monocyte Homeostasis Eosinophil Homeostasis Neuroblast Division In Subventricular Zone Axonogenesis Negative Regulation Of Protein Oligomerization Regulation Of Cell Development L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Regulation Of Tubulin Deacetylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Thrombopoietin-mediated Signaling Pathway Gamma-secretase Complex Positive Regulation Of TORC2 Signaling Positive Regulation Of T-helper 17 Cell Lineage Commitment Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Pre-mRNA Intronic Binding Positive Regulation Of T-helper 17 Cell Differentiation Regulation Of Protein Deacetylation Cellular Response To L-leucine N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation Response To Hypoxia Myeloid Cell Differentiation Peptidyl-lysine Acetylation
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