APH1A and SLC39A9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APH1A	SLC39A9
Description		aph-1A gamma-secretase subunit	solute carrier family 39 member 9
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Golgi Cisterna Membrane Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity	G Protein-coupled Receptor Activity Zinc Ion Transmembrane Transporter Activity Androgen Binding Protein Binding Zinc Efflux Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity
	Biological Process	Metanephros Development Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process	Monoatomic Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Metal Ion Transport Transmembrane Transport Bicellular Tight Junction Assembly Zinc Ion Transmembrane Transport Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Cellular Response To Testosterone Stimulus
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation
Drugs		E-2012 MK-0752
Diseases
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Morning vs. evening chronotype ( 26835600 26955885) Refractive error ( 32231278) Schizophrenia ( 25056061) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		36 interacting genes: ANKRD46 APOD ASGR1 ATF4 BHLHE40 CREB3 DRD2 FIS1 FXYD6 GLP1R GPATCH8 GPR35 HES1 HIVEP1 IGFBP5 KLF11 LAT MFSD6 MPP1 MRAP2 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 SCAND1 SERP1 SLC38A7 SLC39A9 SMAGP THPO TLE1 TMED10 TMEM140 TMEM218 TRARG1	40 interacting genes: ANKRD46 APH1A AQP6 BNIP2 CBARP CD79A CERS3 CPLX4 CRB3 CREB3L1 CREB3L3 CYB5B ELOVL5 EVI2B FCER1G FFAR2 GJA8 GPR101 HERPUD2 HTR2C LNPEP MANBAL MGST3 NEU1 RTP2 SERINC2 SLC10A6 SLC16A2 SLC39A2 SLC61A1 SLC66A1 SLC71A2 SLC7A1 SSMEM1 TM4SF18 TMEM140 TMEM237 TMEM86B TRHR VMP1
Entrez ID		51107	55334
HPRD ID		06360	15387
Ensembl ID		ENSG00000117362	ENSG00000029364
Uniprot IDs		B4DUG7 Q96BI3	B4DDK0 C4N9M8 M0QX28 Q9NUM3
PDB IDs		5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 7Y5T 7Y5X 7Y5Z 8IM7 8K8E 8KCO 8KCP 8KCS 8KCT 8KCU 8X52 8X53 8X54
Enriched GO Terms of Interacting Partners?		Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Amyloid Precursor Protein Metabolic Process Presynaptic Membrane Membrane Protein Proteolysis Notch Signaling Pathway Cajal-Retzius Cell Differentiation Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Cell Surface Receptor Signaling Pathway Growth Factor Receptor Binding Regulation Of Transport Adenohypophysis Development Positive Regulation Of Growth Hormone Secretion Membrane CAMP Response Element Binding Protein Binding Regulation Of Protein Metabolic Process Negative Regulation Of Transport Homeostatic Process Regulation Of Growth Hormone Secretion Membrane Protein Intracellular Domain Proteolysis Golgi Membrane Synaptic Membrane Endoplasmic Reticulum Unfolded Protein Response Circadian Regulation Of Gene Expression Cellular Response To Oxygen-containing Compound Signal Transduction Vesicle Targeting Epithelial Cell Proliferation Protein Processing Endopeptidase Activator Activity Regulation Of Primary Metabolic Process Regulation Of Synaptic Plasticity G Protein-coupled Dopamine Receptor Signaling Pathway Cerebral Cortex Neuron Differentiation	Membrane Lysine Transport Plasma Membrane Positive Regulation Of Acute Inflammatory Response L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport L-lysine Transmembrane Transport Regulation Of Acute Inflammatory Response Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Aromatic Amino Acid Transport L-arginine Transmembrane Transport Azole Transmembrane Transport Endoplasmic Reticulum Membrane Basic Amino Acid Transmembrane Transport Protein Binding Transmembrane Transport Amino Acid Transmembrane Transport Basic Amino Acid Transport Response To Unfolded Protein Phospholipid Scramblase Activity Plasma Membrane Phospholipid Scrambling
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