APH1A and KLF11

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		APH1A	KLF11
Description		aph-1A gamma-secretase subunit	KLF transcription factor 11
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Golgi Cisterna Membrane Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane	Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion Nuclear Body
	Molecular Function	Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Metanephros Development Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Endothelin Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation
Drugs		E-2012 MK-0752
Diseases			Maturity onset diabetes of the young (MODY)
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Morning vs. evening chronotype ( 26835600 26955885) Refractive error ( 32231278) Schizophrenia ( 25056061) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Feeling worry ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196) Mean spheric corpuscular volume ( 32888494) Neurociticism ( 29500382) Prostate cancer ( 23535732)
Interacting Genes		36 interacting genes: ANKRD46 APOD ASGR1 ATF4 BHLHE40 CREB3 DRD2 FIS1 FXYD6 GLP1R GPATCH8 GPR35 HES1 HIVEP1 IGFBP5 KLF11 LAT MFSD6 MPP1 MRAP2 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 SCAND1 SERP1 SLC38A7 SLC39A9 SMAGP THPO TLE1 TMED10 TMEM140 TMEM218 TRARG1	13 interacting genes: APH1A APPBP2 ATXN1 CBX1 CBX3 CLU HDAC1 MAPK1 NFYC SIN3A TIMM13 TXNDC9 YWHAZ
Entrez ID		51107	8462
HPRD ID		06360	04488
Ensembl ID		ENSG00000117362	ENSG00000172059
Uniprot IDs		B4DUG7 Q96BI3	B7ZAX4 O14901 Q53QU8
PDB IDs		5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 7Y5T 7Y5X 7Y5Z 8IM7 8K8E 8KCO 8KCP 8KCS 8KCT 8KCU 8X52 8X53 8X54
Enriched GO Terms of Interacting Partners?		Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Amyloid Precursor Protein Metabolic Process Presynaptic Membrane Membrane Protein Proteolysis Notch Signaling Pathway Cajal-Retzius Cell Differentiation Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Cell Surface Receptor Signaling Pathway Growth Factor Receptor Binding Regulation Of Transport Adenohypophysis Development Positive Regulation Of Growth Hormone Secretion Membrane CAMP Response Element Binding Protein Binding Regulation Of Protein Metabolic Process Negative Regulation Of Transport Homeostatic Process Regulation Of Growth Hormone Secretion Membrane Protein Intracellular Domain Proteolysis Golgi Membrane Synaptic Membrane Endoplasmic Reticulum Unfolded Protein Response Circadian Regulation Of Gene Expression Cellular Response To Oxygen-containing Compound Signal Transduction Vesicle Targeting Epithelial Cell Proliferation Protein Processing Endopeptidase Activator Activity Regulation Of Primary Metabolic Process Regulation Of Synaptic Plasticity G Protein-coupled Dopamine Receptor Signaling Pathway Cerebral Cortex Neuron Differentiation	Negative Regulation Of Gene Expression, Epigenetic Heterochromatin Formation Heterochromatin Chromatin Binding Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Methyltransferase Binding Sin3-type Complex Regulation Of RNA Metabolic Process Enzyme Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of RNA Biosynthetic Process Pericentric Heterochromatin Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Targeting Perinuclear Endoplasmic Reticulum Lumen Nucleus Regulation Of Neuronal Signal Transduction Protein Sequestering Activity Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Nucleoplasm Histone Deacetylase Complex Spindle Negative Regulation Of Protein Localization To Nucleus Site Of DNA Damage Cellular Response To Tert-butyl Hydroperoxide Response To Methylglyoxal Chromatin ERK1 And ERK2 Cascade Rhythmic Process Positive Regulation Of Gliogenesis Transcription Repressor Complex Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Stem Cell Population Maintenance Positive Regulation Of Neurofibrillary Tangle Assembly Krueppel-associated Box Domain Binding Cytosine Metabolic Process Synaptic Target Recognition Negative Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Metabolic Process Protein-containing Complex Regulation Of Gene Expression Central Nervous System Myelin Maintenance
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