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PRMT1 and AXIN1
Number of citations of the paper that reports this interaction (PubMedID
21242974
)
0
Data Source:
BioGRID
(affinity chromatography technology, pull down, enzymatic study)
PRMT1
AXIN1
Description
protein arginine methyltransferase 1
axin 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Lysosome
Lysosomal Membrane
Cytosol
Membrane
Methylosome
Nucleus
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell Cortex
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Cell Periphery
Wnt Signalosome
Molecular Function
RNA Binding
Protein Binding
Methyltransferase Activity
N-methyltransferase Activity
Protein Methyltransferase Activity
Methyl-CpG Binding
Protein-arginine N-methyltransferase Activity
Transferase Activity
Enzyme Binding
Protein-arginine Omega-N Monomethyltransferase Activity
Protein-arginine Omega-N Asymmetric Methyltransferase Activity
Histone Methyltransferase Activity
Identical Protein Binding
Histone H4R3 Methyltransferase Activity
Mitogen-activated Protein Kinase P38 Binding
GATOR1 Complex Binding
Histone H4 Methyltransferase Activity
S-adenosyl-L-methionine Binding
P53 Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Serine/threonine Kinase Activator Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
R-SMAD Binding
Protein Serine/threonine Kinase Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Biological Process
Double-strand Break Repair Via Homologous Recombination
In Utero Embryonic Development
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Protein Methylation
DNA Damage Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
RNA Splicing
Negative Regulation Of Translation
Peptidyl-arginine Methylation
Viral Protein Processing
BMP Signaling Pathway
Regulation Of BMP Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Neuron Projection Development
Cellular Response To Nutrient Levels
Methylation
Cellular Response To Amino Acid Starvation
TORC1 Signaling
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Translation
Negative Regulation Of Translational Initiation
Negative Regulation Of JNK Cascade
Positive Regulation Of Hemoglobin Biosynthetic Process
Cardiac Muscle Tissue Development
Protein Homooligomerization
Cellular Response To Methionine
Protein Localization To Lysosome
Membraneless Organelle Assembly
Positive Regulation Of P38MAPK Cascade
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Protein Polyubiquitination
In Utero Embryonic Development
Nucleocytoplasmic Transport
Apoptotic Process
Sensory Perception Of Sound
Dorsal/ventral Axis Specification
Dorsal/ventral Pattern Formation
Negative Regulation Of Gene Expression
Wnt Signaling Pathway
Protein Catabolic Process
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cytoplasmic Microtubule Organization
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Post-anal Tail Morphogenesis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Epigenetic Programming In The Zygotic Pronuclei
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of JNK Cascade
Axial Mesoderm Development
Axial Mesoderm Formation
Cell Development
Negative Regulation Of Protein Metabolic Process
Canonical Wnt Signaling Pathway
Head Development
Regulation Of Canonical Wnt Signaling Pathway
Protein-containing Complex Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
RMTs methylate histone arginines
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Extra-nuclear estrogen signaling
Estrogen-dependent gene expression
Maturation of nucleoprotein
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
Drugs
S-adenosyl-L-homocysteine
1,4-Dithiothreitol
Diseases
Caudal duplication anomaly
Hepatocellular carcinoma
GWAS
Schizophrenia (
29483656
)
Adult body size (
32376654
)
Appendicular lean mass (
33097823
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Iron status biomarkers (ferritin levels) (
33536631
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics (
32958699
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Waist circumference (
31928498
)
Interacting Genes
165 interacting genes:
AR
ARPC3
ASH2L
AXIN1
BRCA1
BTG1
BTG2
C4orf17
CAPRIN1
CDC37
CEBPA
CEP162
CIRBP
CNOT8
COIL
DAXX
DCAF16
DCAF8
DHX9
EP300
ESR1
EWSR1
FAM83D
FAM9A
FBL
FBXL17
FBXO7
FGF2
FLII
FUS
GLI1
GPATCH2L
GRHL3
GRIP1
H3C1
H4C1
H4C14
H4C16
HABP4
HNF4A
HNRNPA1
HNRNPA3
HNRNPK
HNRNPR
HNRNPU
HNRNPUL1
HROB
IDH3B
IFNAR1
IGSF21
ILF3
KHDRBS1
KHDRBS2
KHDRBS3
LRIF1
MAP3K5
MBD2
MBP
MECOM
MED31
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR138-1
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR206
MIR20A
MIR20B
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR34A
MIR34C
MIR363
MIR451A
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MLST8
NCOA1
NCOA2
NCOA3
NOL4
NRIP1
NTAQ1
OFCC1
PPARA
PPDPF
PRMT8
QKI
RBM15
RELA
RNF187
RPL37A
RPS29
RUNX1
S100A8
SAMD3
SHLD1
SIRT1
SPAG8
SPEG
SPSB1
SPSB2
SRSF1
STAT1
STAT5A
STUB1
SUPT5H
SYNCRIP
TBX6
TERF2
THRB
TK1
TOPORS
TP53
TRIM48
TUBB
UBE4B
USP11
VHL
VPS72
WDFY3
WDR33
YLPM1
YWHAG
ZBTB14
ZCCHC12
ZMYM5
ZNF451
91 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
FXR1
FXR2
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KAT5
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RCHY1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TNKS
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSC1
TSGA10
UCHL5
USP10
USP7
UTP14A
WSB1
ZBTB26
ZFYVE19
Entrez ID
3276
8312
HPRD ID
04257
04819
Ensembl ID
ENSG00000126457
ENSG00000103126
Uniprot IDs
Q99873
A0A0S2Z4R0
A0A0S2Z4S3
O15169
PDB IDs
6NT2
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
6JCK
7SXF
7SXG
7SXH
7SXJ
7Y1P
8RU3
8RU4
8VMG
Enriched GO Terms of Interacting Partners
?
MiRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
RISC Complex
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
MRNA 3'-UTR Binding
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Translation
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Extracellular Vesicle
Regulation Of Translation
MiRNA-mediated Gene Silencing By MRNA Destabilization
Regulation Of MRNA Metabolic Process
Negative Regulation Of Developmental Process
Regulation Of Angiogenesis
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Regulation Of Vasculature Development
Negative Regulation Of Protein Metabolic Process
Regulation Of MRNA Stability
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Vascular Endothelial Growth Factor Production
Regulation Of RNA Stability
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of MRNA Catabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Developmental Process
Positive Regulation Of Metabolic Process
Positive Regulation Of MRNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Multicellular Organismal Development
MRNA Destabilization
Negative Regulation Of Cell Differentiation
Regulation Of Anatomical Structure Morphogenesis
Regulation Of Cell Differentiation
Negative Regulation Of Cytokine Production
Wnt Signaling Pathway
Cytoplasm
Cytosol
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Canonical Wnt Signaling Pathway
Protein Modification By Small Protein Conjugation
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Wnt Signaling Pathway
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Wnt Signalosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Post-translational Protein Modification
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Protein Modification Process
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Component Organization
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Beta-catenin Destruction Complex
Signal Transduction
Beta-catenin Binding
PML Body
Positive Regulation Of Biosynthetic Process
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Tagcloud (Intersection)
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