PRMT1 and SYNCRIP

Number of citations of the paper that reports this interaction (PubMedID 34728620)
66

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, two hybrid)

		PRMT1	SYNCRIP
Description		protein arginine methyltransferase 1	synaptotagmin binding cytoplasmic RNA interacting protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Methylosome	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Endoplasmic Reticulum Cytosol Membrane MRNA Editing Complex CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Histone Pre-mRNA 3'end Processing Complex GAIT Complex MCRD-mediated MRNA Stability Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity Methyl-CpG Binding Protein-arginine N-methyltransferase Activity Transferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone H4R3 Methyltransferase Activity Mitogen-activated Protein Kinase P38 Binding GATOR1 Complex Binding Histone H4 Methyltransferase Activity S-adenosyl-L-methionine Binding	Nucleic Acid Binding RNA Binding Protein Binding MRNA 5'-UTR Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation DNA Damage Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation RNA Splicing Negative Regulation Of Translation Peptidyl-arginine Methylation Viral Protein Processing BMP Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Neuron Projection Development Cellular Response To Nutrient Levels Methylation Cellular Response To Amino Acid Starvation TORC1 Signaling Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation Negative Regulation Of JNK Cascade Positive Regulation Of Hemoglobin Biosynthetic Process Cardiac Muscle Tissue Development Protein Homooligomerization Cellular Response To Methionine Protein Localization To Lysosome Membraneless Organelle Assembly Positive Regulation Of P38MAPK Cascade Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing MRNA Processing Regulation Of Translation RNA Splicing MRNA Modification Negative Regulation Of Translation CRD-mediated MRNA Stabilization Cellular Response To Type II Interferon Chromosomal 5-methylcytosine DNA Demethylation Pathway Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Cytoplasmic Translation
Pathways		RMTs methylate histone arginines TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Extra-nuclear estrogen signaling Estrogen-dependent gene expression Maturation of nucleoprotein
Drugs		S-adenosyl-L-homocysteine
Diseases
GWAS		Schizophrenia ( 29483656)
Interacting Genes		165 interacting genes: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C4orf17 CAPRIN1 CDC37 CEBPA CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EP300 ESR1 EWSR1 FAM83D FAM9A FBL FBXL17 FBXO7 FGF2 FLII FUS GLI1 GPATCH2L GRHL3 GRIP1 H3C1 H4C1 H4C14 H4C16 HABP4 HNF4A HNRNPA1 HNRNPA3 HNRNPK HNRNPR HNRNPU HNRNPUL1 HROB IDH3B IFNAR1 IGSF21 ILF3 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MAP3K5 MBD2 MBP MECOM MED31 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR138-1 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR34A MIR34C MIR363 MIR451A MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 NTAQ1 OFCC1 PPARA PPDPF PRMT8 QKI RBM15 RELA RNF187 RPL37A RPS29 RUNX1 S100A8 SAMD3 SHLD1 SIRT1 SPAG8 SPEG SPSB1 SPSB2 SRSF1 STAT1 STAT5A STUB1 SUPT5H SYNCRIP TBX6 TERF2 THRB TK1 TOPORS TP53 TRIM48 TUBB UBE4B USP11 VHL VPS72 WDFY3 WDR33 YLPM1 YWHAG ZBTB14 ZCCHC12 ZMYM5 ZNF451	111 interacting genes: A1CF APOBEC1 APP CEBPA CIP2A CSDE1 EPRS1 ESR1 FNDC3B GRB2 HABP4 HMGA1 HMGA2 HNRNPD HNRNPK IL7R INSR IVNS1ABP KLHL3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYPOP NUPR1 OGT PABPC1 PCSK7 PLCG1 PRMT1 PTPN11 SMN1 SUMO2 SYT1 SYT11 SYT2 SYT3 SYT4 SYT7 SYT8 SYT9 TRIM55 TRIM63
Entrez ID		3276	10492
HPRD ID		04257	06734
Ensembl ID		ENSG00000126457	ENSG00000135316
Uniprot IDs		Q99873	A0A7I2V309 A0A7I2YQN2 B7Z645 O60506 Q59GL1
PDB IDs		6NT2	2DGU 2MXT 2NBB 6KOR
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Extracellular Vesicle Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of RNA Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Development MRNA Destabilization Negative Regulation Of Cell Differentiation Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Differentiation Negative Regulation Of Cytokine Production	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Translation RNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Metabolic Process Negative Regulation Of Cytokine Production Regulation Of RNA Stability Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Locomotion Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration
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