PRMT1 and IFNAR1

Number of citations of the paper that reports this interaction (PMID 9029147)
27

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo, two hybrid)

		PRMT1	IFNAR1
Gene Name		protein arginine methyltransferase 1	interferon (alpha, beta and omega) receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H4-R3 Specific) Poly(A) RNA Binding	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Protein Methylation Cell Surface Receptor Signaling Pathway Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Neuron Projection Development Histone H4-R3 Methylation Negative Regulation Of Megakaryocyte Differentiation	Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production T Cell Activation Type I Interferon Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines	Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs			Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS			Crohn's disease ( 23128233)
Protein-Protein Interactions		93 interactors: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C17orf53 C20orf196 C4orf17 CAPRIN1 CDC37 CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EIF4A1 ESR1 EWSR1 FAM83D FAM9A FBL FGF2 FLII FUS GPATCH2L GRHL3 GRIP1 HABP4 HIST1H3A HIST1H4A HIST2H4A HIST4H4 HNF4A HNRNPA1 HNRNPK HNRNPR HNRNPU HNRNPUL1 IDH3B IFNAR1 IGSF21 ILF3 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MBP MECOM MED31 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 OFCC1 PIAS1 PPARA PRMT8 QKI RELA RNF187 RUNX1 S100A8 SAMD3 SPAG8 SPEG SPSB1 SPSB2 STAT1 STAT5A SUPT5H SYNCRIP TAF15 TBX6 TERF2 THRB TP53 VHL VPS72 WDFY3 WDR33 WDYHV1 YLPM1 YWHAG ZBTB14 ZMYM5 ZNF451	21 interactors: CRKL FBXW11 GNB2L1 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC STAT2 STAT3 TYK2 ZAP70
Entrez ID		3276	3454
HPRD ID		04257	00126
Ensembl ID		ENSG00000126457	ENSG00000142166
Uniprot IDs		B4DJ87 H7C2I1 Q99873	B4DNT3 P17181
PDB IDs			3S98 3SE3 3SE4
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Gene Expression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process MRNA Processing Chromatin Organization Cellular Process Chromatin Modification Response To Hormone MRNA Metabolic Process RNA Processing Chromosome Organization Cellular Response To Hormone Stimulus Metabolic Process Response To Organic Substance	Regulation Of Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Defense Response Innate Immune Response Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Organic Substance Response To Type I Interferon Regulation Of Cellular Ketone Metabolic Process Response To Cytokine Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Regulation Of Innate Immune Response Regulation Of Protein Phosphorylation Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Organic Substance Signaling Cell Communication Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Cell Adhesion Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of T Cell Activation Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Activation Immune System Development Cellular Response To Stimulus
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted
Tagcloud (Intersection) ?