PRMT1 and SPSB1

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		PRMT1	SPSB1
Gene Name		protein arginine methyltransferase 1	splA/ryanodine receptor domain and SOCS box containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm
	Molecular Function	Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H4-R3 Specific) Poly(A) RNA Binding	Protein Binding
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Protein Methylation Cell Surface Receptor Signaling Pathway Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Neuron Projection Development Histone H4-R3 Methylation Negative Regulation Of Megakaryocyte Differentiation	Protein Ubiquitination Intracellular Signal Transduction
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Dental caries ( 23064961) Immune response to anthrax vaccine ( 22658931) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Protein-Protein Interactions		93 interactors: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C17orf53 C20orf196 C4orf17 CAPRIN1 CDC37 CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EIF4A1 ESR1 EWSR1 FAM83D FAM9A FBL FGF2 FLII FUS GPATCH2L GRHL3 GRIP1 HABP4 HIST1H3A HIST1H4A HIST2H4A HIST4H4 HNF4A HNRNPA1 HNRNPK HNRNPR HNRNPU HNRNPUL1 IDH3B IFNAR1 IGSF21 ILF3 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MBP MECOM MED31 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 OFCC1 PIAS1 PPARA PRMT8 QKI RELA RNF187 RUNX1 S100A8 SAMD3 SPAG8 SPEG SPSB1 SPSB2 STAT1 STAT5A SUPT5H SYNCRIP TAF15 TBX6 TERF2 THRB TP53 VHL VPS72 WDFY3 WDR33 WDYHV1 YLPM1 YWHAG ZBTB14 ZMYM5 ZNF451	10 interactors: ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1
Entrez ID		3276	80176
HPRD ID		04257	18106
Ensembl ID		ENSG00000126457	ENSG00000171621
Uniprot IDs		B4DJ87 H7C2I1 Q99873	Q96BD6
PDB IDs			2JK9 3F2O
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Gene Expression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process MRNA Processing Chromatin Organization Cellular Process Chromatin Modification Response To Hormone MRNA Metabolic Process RNA Processing Chromosome Organization Cellular Response To Hormone Stimulus Metabolic Process Response To Organic Substance	Histone Modification Peptidyl-amino Acid Modification Chromatin Modification Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Organelle Organization RNA Metabolic Process Chromatin Organization Peptidyl-arginine N-methylation Histone H4-R3 Methylation Histone Methylation Negative Regulation Of B Cell Proliferation Histone Arginine Methylation Peptidyl-arginine Methylation Regulation Of Megakaryocyte Differentiation Chromosome Organization Cell Development Protein Methylation Regulation Of RNA Metabolic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nucleobase-containing Compound Metabolic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Immune System Process Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of B Cell Activation Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Response To Hypoxia Regulation Of Cell Death Regulation Of Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Protein Metabolic Process Regulation Of B Cell Proliferation Regulation Of Organelle Organization Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Immune System Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Leukocyte Proliferation Response To Stimulus Cellular Protein Metabolic Process
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	attributable contributes define downregulation emphasizes engineered genetically identifies implicating mammary mediator met neu overexpressing pharmacologic positively potentiation preexisting principal principally promoting protect recurrence relapse spontaneously sufficient turn upregulated
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	attributable contributes define downregulation emphasizes engineered genetically identifies implicating mammary mediator met neu overexpressing pharmacologic positively potentiation preexisting principal principally promoting protect recurrence relapse spontaneously sufficient turn upregulated
Tagcloud (Intersection) ?