PRMT1 and MIR363

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		PRMT1	MIR363
Description		protein arginine methyltransferase 1	microRNA 363
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Methylosome	Extracellular Space
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity Methyl-CpG Binding Protein-arginine N-methyltransferase Activity Transferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone H4R3 Methyltransferase Activity Mitogen-activated Protein Kinase P38 Binding GATOR1 Complex Binding Histone H4 Methyltransferase Activity S-adenosyl-L-methionine Binding	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation DNA Damage Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation RNA Splicing Negative Regulation Of Translation Peptidyl-arginine Methylation Viral Protein Processing BMP Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Neuron Projection Development Cellular Response To Nutrient Levels Methylation Cellular Response To Amino Acid Starvation TORC1 Signaling Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation Negative Regulation Of JNK Cascade Positive Regulation Of Hemoglobin Biosynthetic Process Cardiac Muscle Tissue Development Protein Homooligomerization Cellular Response To Methionine Protein Localization To Lysosome Membraneless Organelle Assembly Positive Regulation Of P38MAPK Cascade Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		RMTs methylate histone arginines TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Extra-nuclear estrogen signaling Estrogen-dependent gene expression Maturation of nucleoprotein
Drugs		S-adenosyl-L-homocysteine
Diseases
GWAS		Schizophrenia ( 29483656)
Interacting Genes		165 interacting genes: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C4orf17 CAPRIN1 CDC37 CEBPA CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EP300 ESR1 EWSR1 FAM83D FAM9A FBL FBXL17 FBXO7 FGF2 FLII FUS GLI1 GPATCH2L GRHL3 GRIP1 H3C1 H4C1 H4C14 H4C16 HABP4 HNF4A HNRNPA1 HNRNPA3 HNRNPK HNRNPR HNRNPU HNRNPUL1 HROB IDH3B IFNAR1 IGSF21 ILF3 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MAP3K5 MBD2 MBP MECOM MED31 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR138-1 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR34A MIR34C MIR363 MIR451A MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 NTAQ1 OFCC1 PPARA PPDPF PRMT8 QKI RBM15 RELA RNF187 RPL37A RPS29 RUNX1 S100A8 SAMD3 SHLD1 SIRT1 SPAG8 SPEG SPSB1 SPSB2 SRSF1 STAT1 STAT5A STUB1 SUPT5H SYNCRIP TBX6 TERF2 THRB TK1 TOPORS TP53 TRIM48 TUBB UBE4B USP11 VHL VPS72 WDFY3 WDR33 YLPM1 YWHAG ZBTB14 ZCCHC12 ZMYM5 ZNF451	94 interacting genes: ADARB1 APOBEC3B ATXN2L C1QBP CDC5L CELF1 CELF2 CHERP DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ESRP1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KIN LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PTCD3 PUF60 PURA PURB QARS1 RARS1 RBFOX2 RBM12B RBM14 RBM4 RTCA RTCB SAFB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SUGP2 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		3276	574031
HPRD ID		04257
Ensembl ID		ENSG00000126457	ENSG00000284499
Uniprot IDs		Q99873
PDB IDs		6NT2
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Extracellular Vesicle Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of RNA Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Development MRNA Destabilization Negative Regulation Of Cell Differentiation Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Differentiation Negative Regulation Of Cytokine Production	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of RNA Splicing Macromolecule Metabolic Process Nucleoplasm Nucleus Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Post-transcriptional Regulation Of Gene Expression Spliceosomal Complex Regulation Of MRNA Processing Catalytic Step 2 Spliceosome Cytoplasmic Stress Granule Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process MiRNA Binding RNA Stabilization TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of Metabolic Process TRNA Aminoacylation Ligase Activity MRNA Stabilization Negative Regulation Of Macromolecule Metabolic Process Pre-mRNA Binding Positive Regulation Of Cytoplasmic Translation Regulation Of MRNA Stability Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process
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