SYNCRIP and SYT1

Number of citations of the paper that reports this interaction (PubMedID 10734137)
0

Data Source:
HPRD (in vitro)

		SYNCRIP	SYT1
Description		synaptotagmin binding cytoplasmic RNA interacting protein	synaptotagmin 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Endoplasmic Reticulum Cytosol Membrane MRNA Editing Complex CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Histone Pre-mRNA 3'end Processing Complex GAIT Complex MCRD-mediated MRNA Stability Complex Ribonucleoprotein Complex	Cytoplasm Golgi Apparatus Plasma Membrane Synaptic Vesicle Postsynaptic Density Membrane Secretory Granule Axon Transport Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Neuron Projection Terminus Synapse Postsynaptic Membrane Presynaptic Active Zone Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding MRNA 5'-UTR Binding	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Syntaxin-1 Binding Syntaxin Binding Clathrin Binding Syntaxin-3 Binding Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding Calcium Ion Sensor Activity Molecular Condensate Scaffold Activity
	Biological Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing MRNA Processing Regulation Of Translation RNA Splicing MRNA Modification Negative Regulation Of Translation CRD-mediated MRNA Stabilization Cellular Response To Type II Interferon Chromosomal 5-methylcytosine DNA Demethylation Pathway Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Cytoplasmic Translation	Detection Of Calcium Ion Vesicle Fusion Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Dopamine Secretion Vesicle Organization Synaptic Vesicle Exocytosis Vesicle-mediated Transport Regulation Of Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Regulation Of Vesicle Fusion Positive Regulation Of Vesicle Fusion Positive Regulation Of Dopamine Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Protein Heterooligomerization Response To Calcium Ion Regulation Of Synaptic Transmission, Glutamatergic Spontaneous Neurotransmitter Secretion Cellular Response To Calcium Ion Synchronous Neurotransmitter Secretion Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium-dependent Activation Of Synaptic Vesicle Fusion Membraneless Organelle Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (botB) Toxicity of botulinum toxin type G (botG) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation
Drugs
Diseases
GWAS			Adiponectin levels ( 33562295) Brain morphology (MOSTest) ( 32665545) Chloride levels ( 29403010) Estimated glomerular filtration rate ( 31217584) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Hand grip strength ( 29313844) Intelligence (MTAG) ( 29326435) Lung function ( 31902109) Lysophosphatidylcholine levels ( 31551469) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) QRS duration ( 31251759) Sodium levels ( 29403010) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653)
Interacting Genes		111 interacting genes: A1CF APOBEC1 APP CEBPA CIP2A CSDE1 EPRS1 ESR1 FNDC3B GRB2 HABP4 HMGA1 HMGA2 HNRNPD HNRNPK IL7R INSR IVNS1ABP KLHL3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYPOP NUPR1 OGT PABPC1 PCSK7 PLCG1 PRMT1 PTPN11 SMN1 SUMO2 SYT1 SYT11 SYT2 SYT3 SYT4 SYT7 SYT8 SYT9 TRIM55 TRIM63	46 interacting genes: BNIP2 BTN2A2 CACNA1A CACNB3 CACNB4 CALM1 CREBBP CSGALNACT2 CYB5B DANCR FGF1 GIMAP5 GOLM1 HMOX2 IKBKG IRF3 MIP NAPB NEDD4 NR1H3 NR3C1 NRXN1 PPARG RACK1 RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A TMEM14C TMEM254 TMEM60 TSHR UBIAD1 ZDHHC17 ZFPL1
Entrez ID		10492	6857
HPRD ID		06734	01710
Ensembl ID		ENSG00000135316	ENSG00000067715
Uniprot IDs		A0A7I2V309 A0A7I2YQN2 B7Z645 O60506 Q59GL1	J3KQA0 P21579
PDB IDs		2DGU 2MXT 2NBB 6KOR	2K45 2K4A 2K8M 2KI6 2LHA 2N1T 2R83 3F00 3F01 3F04 3F05 4ISQ 4V11 6G5F 6G5K 6QNS 6TZ3 6U41 6U4U 6U4W 6ZVN 7TUA 7TX9 7U4Q 8B8I
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Translation RNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Metabolic Process Negative Regulation Of Cytokine Production Regulation Of RNA Stability Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Locomotion Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration	Neurotransmitter Transport Organelle Localization By Membrane Tethering Modulation Of Chemical Synaptic Transmission Membrane Docking Vesicle Docking SNARE Binding Organelle Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling SNAP Receptor Activity Calcium-dependent Protein Binding Secretion By Cell Secretion SNARE Complex Vesicle-mediated Transport In Synapse Membrane Fusion Vesicle Fusion Regulation Of Cell Communication Regulation Of Signaling Organelle Membrane Fusion Synapse Regulation Of Regulated Secretory Pathway Exocytosis Vesicle-mediated Transport Organelle Fusion Chemical Synaptic Transmission Glutamatergic Synapse Positive Regulation Of Signal Transduction Positive Regulation Of Synaptic Transmission Trans-synaptic Signaling Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Neurotransmitter Secretion Regulation Of Protein Localization Synaptic Signaling Regulation Of Biological Quality Synaptic Vesicle Docking Signal Release Establishment Of Localization In Cell Calcium Channel Regulator Activity Positive Regulation Of Immune Response Regulation Of Synaptic Vesicle Exocytosis Regulation Of Exocytosis Somatodendritic Compartment Regulation Of Vesicle-mediated Transport Activation Of Immune Response Long-term Synaptic Potentiation Regulation Of Secretion By Cell Regulation Of Membrane Potential Cell-cell Signaling Presynaptic Membrane
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