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SYNCRIP and HMGA2
Number of citations of the paper that reports this interaction (PubMedID
18850631
)
0
Data Source:
BioGRID
(far western blotting)
SYNCRIP
HMGA2
Description
synaptotagmin binding cytoplasmic RNA interacting protein
high mobility group AT-hook 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Spliceosomal Complex
Cytoplasm
Endoplasmic Reticulum
Cytosol
Membrane
MRNA Editing Complex
CRD-mediated MRNA Stability Complex
Catalytic Step 2 Spliceosome
Histone Pre-mRNA 3'end Processing Complex
GAIT Complex
MCRD-mediated MRNA Stability Complex
Ribonucleoprotein Complex
Nuclear Chromosome
Chromatin
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Protein-DNA Complex
Senescence-associated Heterochromatin Focus
SMAD Protein Complex
Molecular Function
Nucleic Acid Binding
RNA Binding
Protein Binding
MRNA 5'-UTR Binding
Transcription Cis-regulatory Region Binding
Nucleic Acid Binding
DNA Binding
Minor Groove Of Adenine-thymine-rich DNA Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Protein Binding
DNA Binding, Bending
Enzyme Binding
Nucleosomal DNA Binding
CAMP Response Element Binding
MH2 Domain Binding
MH1 Domain Binding
SMAD Binding
5'-deoxyribose-5-phosphate Lyase Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
C2H2 Zinc Finger Domain Binding
Biological Process
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
RNA Processing
MRNA Processing
Regulation Of Translation
RNA Splicing
MRNA Modification
Negative Regulation Of Translation
CRD-mediated MRNA Stabilization
Cellular Response To Type II Interferon
Chromosomal 5-methylcytosine DNA Demethylation Pathway
Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Positive Regulation Of Cytoplasmic Translation
Negative Regulation Of Transcription By RNA Polymerase II
Epithelial To Mesenchymal Transition
Chondrocyte Differentiation
Mesodermal-endodermal Cell Signaling
Base-excision Repair
Chromatin Organization
Regulation Of DNA-templated Transcription
Spermatogenesis
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Male Gonad Development
Response To Virus
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle Process
Positive Regulation Of Gene Expression
Cell Proliferation In Forebrain
Pituitary Gland Development
Negative Regulation Of Wnt Signaling Pathway
Chromosome Condensation
Adrenal Gland Development
Heterochromatin Formation
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Somatic Stem Cell Population Maintenance
Multicellular Organism Growth
Intracellular Signal Transduction
Endodermal Cell Differentiation
Chondrocyte Proliferation
Positive Regulation Of Multicellular Organism Growth
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Host-mediated Suppression Of Viral Transcription
Fat Cell Differentiation
Positive Regulation Of Angiogenesis
Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Mesodermal Cell Differentiation
Astrocyte Differentiation
Negative Regulation Of Astrocyte Differentiation
Mesenchymal Cell Differentiation
Stem Cell Differentiation
Cell Division
Regulation Of Growth Hormone Secretion
Lung Epithelium Development
Epithelial Tube Branching Involved In Lung Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Adipose Tissue Development
Fat Pad Development
Positive Regulation Of Cell Proliferation In Bone Marrow
Positive Regulation Of Protein Serine/threonine Kinase Activity
Stem Cell Proliferation
Regulation Of Peptide Hormone Secretion
Oncogene-induced Cell Senescence
Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Stem Cell Proliferation
Negative Regulation Of Cellular Senescence
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS
Adverse response to drug (
30420678
)
Aortic root size (
19584346
)
Appendicular lean mass (
33097823
)
Axial length (
24144296
)
Birth length (
25281659
)
Birth weight (
31043758
27680694
23202124
)
Body size at age 10 (
32376654
)
Brain structure (
22504417
)
Childhood body mass index (
33045005
)
Chin dimples (
27182965
)
Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) (
30940143
)
Cortical surface area (global PC1) (
32198502
)
Cortical volume (
32963231
)
Fasting insulin (
34059833
)
Haemorrhoidal disease (
33888516
)
Head circumference (infant) (
22504419
)
Heart rate response to exercise (
29769521
)
Heel bone mineral density (
30598549
)
Height (
25282103
18391952
28552196
20881960
18391951
18391950
25429064
19343178
21998595
20397748
23563607
22021425
31562340
17767157
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
25673412
34021172
)
Hip index (
34021172
)
Infant length (
25281659
)
Late-onset Alzheimer's disease (
27770636
)
Medication use (drugs used in diabetes) (
31015401
)
Neutrophil count (
32888494
)
Offspring birth weight (
31043758
)
Permanent tooth development (
21931568
)
Plateletcrit (
32888494
)
Polycystic ovary syndrome (
22885925
)
Primary tooth development (number of teeth) (
20195514
23704328
)
Primary tooth development (time to first tooth eruption) (
23704328
20195514
)
Pulse pressure (
27841878
)
Systolic blood pressure (
27841878
31928498
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
32499647
28869590
20581827
30297969
30054458
29358691
26961502
25102180
24509480
22885922
)
Type 2 diabetes nephropathy (
21150874
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for body mass index (
25673412
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
111 interacting genes:
A1CF
APOBEC1
APP
CEBPA
CIP2A
CSDE1
EPRS1
ESR1
FNDC3B
GRB2
HABP4
HMGA1
HMGA2
HNRNPD
HNRNPK
IL7R
INSR
IVNS1ABP
KLHL3
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
MYPOP
NUPR1
OGT
PABPC1
PCSK7
PLCG1
PRMT1
PTPN11
SMN1
SUMO2
SYT1
SYT11
SYT2
SYT3
SYT4
SYT7
SYT8
SYT9
TRIM55
TRIM63
21 interacting genes:
APEX1
CDK1
CSNK2A1
CSNK2A2
E4F1
KAT2B
MDM2
NFKB1
NPM1
PA2G4
PCBP2
PIAS3
PRKCA
PRMT6
PSIP1
PTBP1
RB1
RELA
SMAD3
SYNCRIP
TP53
Entrez ID
10492
8091
HPRD ID
06734
02827
Ensembl ID
ENSG00000135316
ENSG00000149948
Uniprot IDs
A0A7I2V309
A0A7I2YQN2
B7Z645
O60506
Q59GL1
F5H2A4
F5H6H0
P52926
Q1M183
PDB IDs
2DGU
2MXT
2NBB
6KOR
Enriched GO Terms of Interacting Partners
?
MiRNA-mediated Post-transcriptional Gene Silencing
RISC Complex
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
MRNA 3'-UTR Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
MiRNA-mediated Gene Silencing By Inhibition Of Translation
MiRNA-mediated Gene Silencing By MRNA Destabilization
Extracellular Vesicle
Negative Regulation Of Translation
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
MRNA Destabilization
Positive Regulation Of MRNA Catabolic Process
Regulation Of Translation
RNA Destabilization
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of MRNA Metabolic Process
Regulation Of MRNA Stability
Regulation Of Metabolic Process
Negative Regulation Of Cytokine Production
Regulation Of RNA Stability
Regulation Of Angiogenesis
Negative Regulation Of Cell Migration
Regulation Of Vasculature Development
Negative Regulation Of Vascular Endothelial Growth Factor Production
Negative Regulation Of Cell Motility
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Locomotion
Regulation Of MRNA Metabolic Process
Negative Regulation Of Developmental Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Anatomical Structure Morphogenesis
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Endothelial Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Cell Migration
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Gene Expression
Nucleoplasm
Negative Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Metabolic Process
Regulation Of Metabolic Process
Nucleic Acid Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Chromatin Organization
Nucleus
Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
Chromatin Binding
Positive Regulation Of Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Chromatin Remodeling
Regulation Of Cell Differentiation
Ubiquitin Protein Ligase Binding
Positive Regulation Of Transcription By RNA Polymerase II
Response To Peptide Hormone
DNA-binding Transcription Factor Binding
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle Process
DNA Metabolic Process
Signal Transduction Involved In Regulation Of Gene Expression
Response To Stress
Regulation Of Cell Cycle
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Response To Oxidative Stress
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