SYNCRIP and KLHL3

Number of citations of the paper that reports this interaction (PMID 10734137)
17

Data Source:
HPRD (in vitro)

		SYNCRIP	KLHL3
Gene Name		synaptotagmin binding, cytoplasmic RNA interacting protein	kelch-like family member 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Ribonucleoprotein Complex CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Histone Pre-mRNA 3'end Processing Complex GAIT Complex	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Poly(A) Binding Poly(A) RNA Binding	Actin Binding Structural Molecule Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing RNA Splicing Viral Process Negative Regulation Of Translation CRD-mediated MRNA Stabilization Cellular Response To Interferon-gamma	Protein Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ion Homeostasis Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: A1CF APOBEC1 APP CSDE1 EPRS GRB2 HABP4 HMGA1 HMGA2 HNRNPD HNRNPK IL7R INSR IVNS1ABP KLHL3 NUPR1 PABPC1 PCSK7 PLCG1 PRMT1 PRMT8 PTPN11 SMN1 SYT1 SYT11 SYT2 SYT3 SYT4 SYT7 SYT8 SYT9	12 interactors: C6orf165 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 MORF4L2 OPRD1 SYNCRIP SYT2 WNK3 WNK4
Entrez ID		10492	26249
HPRD ID		06734	09011
Ensembl ID		ENSG00000135316	ENSG00000146021
Uniprot IDs		B7Z645 O60506 Q59GL1	Q9UH77
PDB IDs		2DGU	4HXI
Enriched GO Terms of Interacting Partners?		Exocytosis MRNA Metabolic Process RNA Processing Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis MRNA Processing Cytidine To Uridine Editing Oncogene-induced Cell Senescence Secretion By Cell Positive Regulation Of Transport Senescence-associated Heterochromatin Focus Assembly Regulation Of Vesicle-mediated Transport Positive Regulation Of Cellular Senescence Regulation Of Vesicle Fusion Secretion Regulation Of Secretion RNA Metabolic Process Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of Chromatin Silencing Base Conversion Or Substitution Editing Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Cellular Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Cell Aging Vesicle-mediated Transport Viral Process Positive Regulation Of Exocytosis RNA Splicing Regulation Of Growth Hormone Secretion Wound Healing Regulation Of Gene Expression Heterochromatin Assembly Positive Regulation Of Protein Metabolic Process Peptidyl-arginine N-methylation Histone H4-R3 Methylation Positive Regulation Of Metabolic Process Cellular Response To Insulin Stimulus Gene Expression Regulation Of Peptide Hormone Secretion Heterochromatin Organization Blood Coagulation Reproductive Process Hemostasis MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Response To Wounding	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus COPII Vesicle Coating G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger COPII-coated Vesicle Budding Regulation Of Calcium Ion Transport Vesicle Targeting, To, From Or Within Golgi Vesicle Organization Protein Monoubiquitination Localization Within Membrane Vesicle Targeting Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rubidium Ion Transport Positive Regulation Of Rubidium Ion Transmembrane Transporter Activity Positive Regulation Of Proteasomal Protein Catabolic Process Membrane Budding ER To Golgi Vesicle-mediated Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Distal Tubule Morphogenesis Trophectodermal Cellular Morphogenesis Positive Regulation Of Protein Metabolic Process Renal Sodium Ion Absorption Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport CRD-mediated MRNA Stabilization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Regulation Of Rubidium Ion Transport Protein Modification By Small Protein Conjugation Regulation Of Ion Transport Cytoplasmic Transport Signal Transduction Response To Organic Substance Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Wnt Signaling Pathway Response To Cytokine Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Establishment Of Vesicle Localization Vesicle Localization
Tagcloud ?		autonomy back bmp bottom connections correct explained genetically glass highlight influences maintaining modulates morphogenic motoneuron output partly plasticity postsynaptic presynaptic probability proper retrograde signals synapse synaptic transmission unexpected vesicle	aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnk4 wnks
Tagcloud (Difference) ?		autonomy back bmp bottom connections correct explained genetically glass highlight influences maintaining modulates morphogenic motoneuron output partly plasticity postsynaptic presynaptic probability proper retrograde signals synapse synaptic transmission unexpected vesicle	aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnk4 wnks
Tagcloud (Intersection) ?