SYNCRIP and PCSK7

Number of citations of the paper that reports this interaction (PMID 11051545)
81

Data Source:
HPRD (in vivo)

		SYNCRIP	PCSK7
Gene Name		synaptotagmin binding, cytoplasmic RNA interacting protein	proprotein convertase subtilisin/kexin type 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Ribonucleoprotein Complex CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Histone Pre-mRNA 3'end Processing Complex GAIT Complex	Integral Component Of Golgi Membrane
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Poly(A) Binding Poly(A) RNA Binding	Serine-type Endopeptidase Activity Peptidase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing RNA Splicing Viral Process Negative Regulation Of Translation CRD-mediated MRNA Stabilization Cellular Response To Interferon-gamma	Proteolysis Protein Processing Peptide Hormone Processing
Pathways
Drugs
Diseases
GWAS			Cardiovascular disease risk factors ( 21943158) Iron status biomarkers ( 21149283)
Protein-Protein Interactions		31 interactors: A1CF APOBEC1 APP CSDE1 EPRS GRB2 HABP4 HMGA1 HMGA2 HNRNPD HNRNPK IL7R INSR IVNS1ABP KLHL3 NUPR1 PABPC1 PCSK7 PLCG1 PRMT1 PRMT8 PTPN11 SMN1 SYT1 SYT11 SYT2 SYT3 SYT4 SYT7 SYT8 SYT9	6 interactors: CSDE1 HNRNPD HSPA5 PABPC1 PMCH SYNCRIP
Entrez ID		10492	9159
HPRD ID		06734	05339
Ensembl ID		ENSG00000135316
Uniprot IDs		B7Z645 O60506 Q59GL1	Q16549
PDB IDs		2DGU
Enriched GO Terms of Interacting Partners?		Exocytosis MRNA Metabolic Process RNA Processing Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis MRNA Processing Cytidine To Uridine Editing Oncogene-induced Cell Senescence Secretion By Cell Positive Regulation Of Transport Senescence-associated Heterochromatin Focus Assembly Regulation Of Vesicle-mediated Transport Positive Regulation Of Cellular Senescence Regulation Of Vesicle Fusion Secretion Regulation Of Secretion RNA Metabolic Process Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of Chromatin Silencing Base Conversion Or Substitution Editing Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Cellular Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Cell Aging Vesicle-mediated Transport Viral Process Positive Regulation Of Exocytosis RNA Splicing Regulation Of Growth Hormone Secretion Wound Healing Regulation Of Gene Expression Heterochromatin Assembly Positive Regulation Of Protein Metabolic Process Peptidyl-arginine N-methylation Histone H4-R3 Methylation Positive Regulation Of Metabolic Process Cellular Response To Insulin Stimulus Gene Expression Regulation Of Peptide Hormone Secretion Heterochromatin Organization Blood Coagulation Reproductive Process Hemostasis MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Response To Wounding	Regulation Of MRNA Stability Regulation Of RNA Stability MRNA Metabolic Process RNA Catabolic Process MRNA Stabilization MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Macromolecule Catabolic Process Regulation Of Translation RNA Splicing MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Translation Regulation Of Protein Folding In Endoplasmic Reticulum RNA Processing Catabolic Process Cerebellum Structural Organization Nuclear-transcribed MRNA Catabolic Process Regulation Of Cellular Protein Metabolic Process MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Protein Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization Circadian Regulation Of Translation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process ER Overload Response Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Maintenance Of Protein Localization In Endoplasmic Reticulum Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Regulation Of MRNA 3'-end Processing Cellular Response To Antibiotic Anatomical Structure Arrangement Positive Regulation Of MRNA Catabolic Process Cellular Response To Toxic Substance Cellular Response To Glucose Starvation Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Polyadenylation Cellular Response To Cytokine Stimulus Cerebellar Purkinje Cell Layer Development RNA Polyadenylation Substantia Nigra Development ER-associated Ubiquitin-dependent Protein Catabolic Process Toxin Transport Cellular Response To Interleukin-4 Response To Cytokine
Tagcloud ?		autonomy back bmp bottom connections correct explained genetically glass highlight influences maintaining modulates morphogenic motoneuron output partly plasticity postsynaptic presynaptic probability proper retrograde signals synapse synaptic transmission unexpected vesicle	aric atherogenic atherosclerosis biracial chd close communities confidence dense discovered hazard hazards homogeneous incident insights interval ldl lipid lipoprotein loci locus lowest mellitus newly proportional quartile sdldl traits variants
Tagcloud (Difference) ?		autonomy back bmp bottom connections correct explained genetically glass highlight influences maintaining modulates morphogenic motoneuron output partly plasticity postsynaptic presynaptic probability proper retrograde signals synapse synaptic transmission unexpected vesicle	aric atherogenic atherosclerosis biracial chd close communities confidence dense discovered hazard hazards homogeneous incident insights interval ldl lipid lipoprotein loci locus lowest mellitus newly proportional quartile sdldl traits variants
Tagcloud (Intersection) ?