PRICKLE4 and OTX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRICKLE4	OTX1
Description		prickle planar cell polarity protein 4	orthodenticle homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Adherens Junction Z Disc Filamentous Actin	Chromatin Nucleus
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Muscle Alpha-actinin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Muscle Structure Development	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Metencephalon Development Forebrain Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis
Pathways
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Fruit consumption ( 32066663) Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		9 interacting genes: AGXT GNE HOXA1 MTDH NEK6 OTX1 PLEKHN1 ZNF417 ZNF587	148 interacting genes: ADAM12 ADAMTSL4 ALPP ANKRD10 ARHGEF17 ARID5A ATG9B C10orf55 CCN4 CERCAM CFAP68 CH25H CHIC2 CHRD CHRDL2 COL8A1 COMP CTAG2 CYSRT1 DPY30 EFEMP2 ETFDH FAM168B FAM72B FBLN2 FBLN5 FHL5 GEMIN8P4 GPRASP3 GPRIN2 GRN HIVEP1 HOXA1 INTS11 KCNK16 KLHL26 KPRP KRT31 KRT35 KRT37 KRT81 KRT85 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1C LCE1F LCE2A LCE2B LCE2C LCE2D LCE4A LGALS13 M1AP MDFI MGAT5B MIIP MTNR1B NBPF19 NDUFAF6 NECTIN3 NHLRC4 NOTCH2NLA OXER1 PCSK5 PLA2G10 PLEKHG4 PLSCR2 POU2AF1 PRICKLE4 PRR13 PRR22 RBPMS RGS17 RGS19 RGS20 RNF144B RTN4R SLC15A2 SMARCC1 SPMIP9 SPRY1 SPRY2 SPRY4 SPRYD7 TLE4 TNS2 TRIM42 TRIP6 TSPAN4 UBAP2 USP54 VWC2 VWC2L WWOX YPEL3 ZBTB42 ZNF330 ZNF34
Entrez ID		29964	5013
HPRD ID		12884	08964
Ensembl ID		ENSG00000278224	ENSG00000115507
Uniprot IDs		Q2TBC4	P32242
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-serine-pyruvate Transaminase Activity Oxalic Acid Secretion Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Diencephalon Morphogenesis N-acylmannosamine Kinase Activity N-acetylneuraminate Biosynthetic Process N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity Glycine Biosynthetic Process Glyoxylate Catabolic Process L-alanine Catabolic Process Alanine-glyoxylate Transaminase Activity L-alanine Metabolic Process L-cysteine Catabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Metencephalon Development CMP-N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process	Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Protein Binding Structural Molecule Activity Cytosol Structural Constituent Of Skin Epidermis Negative Regulation Of Cellular Response To Growth Factor Stimulus
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