PRICKLE4 and PLEKHN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRICKLE4	PLEKHN1
Description		prickle planar cell polarity protein 4	pleckstrin homology domain containing N1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Adherens Junction Z Disc Filamentous Actin	Mitochondrion Cytosol Cytoskeleton Plasma Membrane Membrane Mitochondrial Membrane
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Muscle Alpha-actinin Binding	Phosphatidylserine Binding Protein Binding Phosphatidic Acid Binding Cardiolipin Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Muscle Structure Development	Response To Hypoxia Positive Regulation Of Apoptotic Process 3'-UTR-mediated MRNA Destabilization
Pathways
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Height ( 31562340) Parkinson's disease ( 26227905)
Interacting Genes		9 interacting genes: AGXT GNE HOXA1 MTDH NEK6 OTX1 PLEKHN1 ZNF417 ZNF587	42 interacting genes: ABI2 AKAP8L ARID5A ATXN1 CBY2 CYSRT1 FHL5 HOXA1 KRT31 KRT36 KRT83 KRTAP1-3 KRTAP19-6 KRTAP6-2 LPXN LZTS2 MTUS2 NBPF19 NFKBID NOTCH2NLA PDLIM7 PIH1D1 PPM1J PPP1R16B PRICKLE4 PRKAA2 REL RFX6 SAXO4 SORBS3 SSC4D TAX1BP1 TCF4 TP53BP2 TRAF1 TRIM27 TRIP6 USP54 WWOX ZC4H2 ZNF438 ZRANB1
Entrez ID		29964	84069
HPRD ID		12884	13190
Ensembl ID		ENSG00000278224	ENSG00000187583
Uniprot IDs		Q2TBC4	Q494U1
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-serine-pyruvate Transaminase Activity Oxalic Acid Secretion Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Diencephalon Morphogenesis N-acylmannosamine Kinase Activity N-acetylneuraminate Biosynthetic Process N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity Glycine Biosynthetic Process Glyoxylate Catabolic Process L-alanine Catabolic Process Alanine-glyoxylate Transaminase Activity L-alanine Metabolic Process L-cysteine Catabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Metencephalon Development CMP-N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process	Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament
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