PRICKLE4 and AGXT

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid, two hybrid)

		PRICKLE4	AGXT
Name		prickle planar cell polarity protein 4	alanine--glyoxylate aminotransferase
Structure		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Adherens Junction Z Disc Filamentous Actin	Cytoplasm Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Muscle Alpha-actinin Binding	L-serine-pyruvate Transaminase Activity Protein Binding Alanine-glyoxylate Transaminase Activity Transaminase Activity Amino Acid Binding Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Heart Development Actin Cytoskeleton Organization Muscle Structure Development	L-serine Metabolic Process Notch Signaling Pathway Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-cysteine Catabolic Process L-alanine Catabolic Process Glyoxylate Metabolic Process Oxalic Acid Secretion
Pathways		None	Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs		None	Pyridoxal phosphate Serine Glycine Alanine Aminooxyacetic acid N(6)-(pyridoxal phosphate)-L-lysine 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
Diseases		None	Primary hyperoxaluria (HP)
GWAS		Hip circumference adjusted for BMI ( 34021172 )	Height ( 25282103 31562340 ) Urinary metabolites ( 26352407 )
Novel Interactors		1 novel interactors: CNTN4	1 novel interactors: LYN
Interacting Genes		9 interacting genes: AGXT GNE HOXA1 MTDH NEK6 OTX1 PLEKHN1 ZNF417 ZNF587	39 interacting genes: ACAT1 ACTMAP ATXN1L BATF3 CFAP68 CHIC2 CYSRT1 EFS FAM168B FHL5 FNTB FOSB GLP1R HOXA1 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP12-3 KRTAP3-1 KRTAP6-3 KRTAP8-1 KRTAP9-2 LPXN MDFI MORN5 NBPF19 NOTCH2NLA OIP5 PEX5 PLA2G10 PRDM6 PRICKLE4 RFX6 SNCAIP SPRYD7 TRAPPC14 TTC19
Entrez ID		29964	189
HPRD ID		12884	05048
Ensembl ID		ENSG00000278224	ENSG00000172482
Uniprot IDs		Q2TBC4	P21549
PDB IDs		Not available	1H0C 1J04 2YOB 3R9A 4CBR 4CBS 4I8A 4KXK 4KYO 5F9S 5HHY 5LUC 5OFY 5OG0 6RV0 6RV1 7NS7
GO Terms Enriched among Interactors		Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-serine-pyruvate Transaminase Activity Oxalic Acid Secretion Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Diencephalon Morphogenesis N-acylmannosamine Kinase Activity N-acetylneuraminate Biosynthetic Process N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity Glycine Biosynthetic Process Glyoxylate Catabolic Process L-alanine Catabolic Process Alanine-glyoxylate Transaminase Activity L-alanine Metabolic Process L-cysteine Catabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Metencephalon Development CMP-N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process	Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Negative Regulation Of B Cell Receptor Signaling Pathway