MED31 and CACNB4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED31	CACNB4
Gene Name		mediator complex subunit 31	calcium channel, voltage-dependent, beta 4 subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mediator Complex	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Synapse
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding Protein Complex Binding	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Protein Kinase Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Protein Complex Assembly Gene Expression Negative Regulation Of Fibroblast Proliferation Limb Development	Transport Cellular Calcium Ion Homeostasis Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Axon Guidance Neuromuscular Junction Development Adult Walking Behavior Gamma-aminobutyric Acid Secretion Neuronal Action Potential Propagation Synaptic Transmission, Glutamatergic CAMP Metabolic Process Spleen Development Thymus Development Peyer's Patch Development Muscle Fiber Development T Cell Receptor Signaling Pathway Detection Of Light Stimulus Involved In Visual Perception Membrane Depolarization Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		58 interactors: AES AGR2 ANXA7 ASCC2 C2orf44 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 UBE2B ZBTB45 ZSCAN1	9 interactors: CACNA1A CBX3 FASLG MAP1A MED31 PTN REM1 SYT1 TBL3
Entrez ID		51003	785
HPRD ID		14382	09057
Ensembl ID		ENSG00000108590	ENSG00000182389
Uniprot IDs		Q9Y3C7	E7DBM8 O00305
PDB IDs			1VYV 2D46
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Developmental Process Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Differentiation Multicellular Organismal Development Response To Stimulus Neurotransmitter Uptake Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Telomere Maintenance Via Semi-conservative Replication System Development Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Cell Death Telomere Maintenance Via Recombination Nuclear DNA Replication Mitotic DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Embryo Development Ending In Birth Or Egg Hatching DNA-templated Transcription, Initiation Response To External Stimulus Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Protein Metabolic Process	Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Chloride Ion Homeostasis Anion Homeostasis Regulation Of Calcium Ion-dependent Exocytosis Acid Secretion Cerebellar Molecular Layer Development Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Neurotransmitter Secretion Vestibular Nucleus Development Cerebellum Maturation G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Musculoskeletal Movement, Spinal Reflex Action Endosomal Lumen Acidification Regulation Of Neurotransmitter Levels Regulation Of Exocytosis Retinal Cell Programmed Cell Death Gamma-aminobutyric Acid Secretion Amino Acid Transport Neurotransmitter Transport Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Necroptotic Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Inflammatory Cell Apoptotic Process Gamma-aminobutyric Acid Transport Regulation Of Neuron Apoptotic Process Cell-cell Signaling Positive Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Hormone Biosynthetic Process Detection Of Calcium Ion Pons Development Regulation Of Neuron Death Positive Regulation Of Calcium Ion-dependent Exocytosis Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Cerebellar Purkinje Cell Differentiation Exocytosis T Cell Apoptotic Process Cerebellar Purkinje Cell Layer Morphogenesis Positive Regulation Of Vesicle Fusion Signaling Neurological System Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Intracellular PH Reduction Cell Communication Regulation Of Vesicle-mediated Transport Reflex PH Reduction
Tagcloud ?			altering concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a ppp2r5 ppp2r5d prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage
Tagcloud (Difference) ?			altering concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a ppp2r5 ppp2r5d prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage
Tagcloud (Intersection) ?