MED31 and CACNB4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED31	CACNB4
Description		mediator complex subunit 31	calcium voltage-gated channel auxiliary subunit beta 4
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Nuclear Speck Monoatomic Ion Channel Complex Synapse Presynapse Glutamatergic Synapse
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Channel Activity Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation RNA Polymerase II Preinitiation Complex Assembly Limb Development Positive Regulation Of Transcription Initiation By RNA Polymerase II	Monoatomic Ion Transport Calcium Ion Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Neuromuscular Junction Development Adult Walking Behavior Negative Regulation Of Cell Population Proliferation Gamma-aminobutyric Acid Secretion Neuronal Action Potential Propagation Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential CAMP Metabolic Process Spleen Development Thymus Development Peyer's Patch Development T Cell Receptor Signaling Pathway Nervous System Process Detection Of Light Stimulus Involved In Visual Perception Muscle Cell Development Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Protein Localization To Nucleolus Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Synaptic Vesicle Exocytosis
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Presynaptic depolarization and calcium channel opening NCAM1 interactions
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Nicardipine Magnesium sulfate Verapamil Levomenthol Nitrendipine Miconazole Amiodarone Mibefradil Dronedarone Nilvadipine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases			Episodic ataxias Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Idiopathic dilated cardiomyopathy ( 29495422) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		58 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED8 MED9 MOB4 NAF1 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1	13 interacting genes: CACNA1A CBX3 CCDC102B CTBP2 EFHC2 FASLG MAP1A MED31 PTN REM1 SNCA SYT1 TBL3
Entrez ID		51003	785
HPRD ID		14382	09057
Ensembl ID		ENSG00000108590	ENSG00000182389
Uniprot IDs		Q9Y3C7	A0A1B0GTK1 A0A1B0GTP5 A0A1B0GTX8 E7DBM8 H0Y476 O00305
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	2D46
Enriched GO Terms of Interacting Partners?		Nucleus Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Identical Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Protein Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA-templated Transcription Elongation Nucleoplasm	Modulation Of Chemical Synaptic Transmission Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Vesicle Fusion Regulation Of Dopamine Secretion Syntaxin Binding Synapse Transcription Coregulator Binding Regulation Of Synaptic Plasticity Dendrite Development Tau Protein Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Vesicle Fusion Positive Regulation Of SNARE Complex Assembly Regulation Of Catecholamine Secretion Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Neurotransmitter Secretion Synaptic Vesicle Exocytosis Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Cell-cell Signaling Signaling Cell Communication Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Chemical Synaptic Transmission Retrograde Axonal Protein Transport Primary Dendrite Dendrite Regeneration SNARE Binding Regulation Of Norepinephrine Uptake Regulation Of Amine Transport Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Syntaxin-3 Binding Calcium Ion Transmembrane Import Into Cytosol Retinal Cell Programmed Cell Death Trans-synaptic Signaling Synaptic Signaling Neuronal Cell Body Dendritic Branch Dendritic Microtubule Ossification Involved In Bone Remodeling Negative Regulation Of Serotonin Uptake Positive Regulation Of Exocytosis Transporter Regulator Activity Regulation Of Neurotransmitter Secretion Vesicle-mediated Transport In Synapse Negative Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
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