MED31 and UBE2B

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED31	UBE2B
Gene Name		mediator complex subunit 31	ubiquitin-conjugating enzyme E2B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mediator Complex	Chromatin Nuclear Chromatin XY Body Nucleus Replication Fork Cytoplasm Plasma Membrane HULC Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding Protein Complex Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Protein Complex Assembly Gene Expression Negative Regulation Of Fibroblast Proliferation Limb Development	Protein Polyubiquitination Response To Hypoxia In Utero Embryonic Development DNA Repair Postreplication Repair Maintenance Of Chromatin Silencing Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Spermatogenesis Sperm Axoneme Assembly Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Cellular Response To Insulin Stimulus Negative Regulation Of Histone Phosphorylation Histone H2A Ubiquitination Response To Drug Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling Protein Stabilization Chiasma Assembly Protein Autoubiquitination Canonical Wnt Signaling Pathway Histone Lysine Demethylation Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		58 interactors: AES AGR2 ANXA7 ASCC2 C2orf44 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 UBE2B ZBTB45 ZSCAN1	19 interactors: BIRC2 CDKN1B CNOT4 CRMP1 CTNNB1 HIST2H2AC MED31 PCNA RAD18 RNF20 RNF40 TRIM45 UBA1 UBC UBR1 UBR2 UBR3 UBR5 UNC119
Entrez ID		51003	7320
HPRD ID		14382	01533
Ensembl ID		ENSG00000108590	ENSG00000119048
Uniprot IDs		Q9Y3C7	P63146
PDB IDs			1JAS 1NXA 2Y4W 2YB6 2YBF
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Developmental Process Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Differentiation Multicellular Organismal Development Response To Stimulus Neurotransmitter Uptake Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Telomere Maintenance Via Semi-conservative Replication System Development Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Cell Death Telomere Maintenance Via Recombination Nuclear DNA Replication Mitotic DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Embryo Development Ending In Birth Or Egg Hatching DNA-templated Transcription, Initiation Response To External Stimulus Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Protein Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Response To Leucine Proteolysis Histone Ubiquitination Cellular Protein Modification Process Regulation Of Protein K63-linked Ubiquitination Protein Polyubiquitination Response To Cadmium Ion Response To Leucine Histone H2B Ubiquitination Cellular Response To DNA Damage Stimulus Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Response To Amino Acid Cell Cycle Process Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process Histone Monoubiquitination Regulation Of Histone Modification Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Negative Regulation Of TOR Signaling Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organonitrogen Compound Positive Regulation Of Histone Methylation Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Chromosome Organization Negative Regulation Of Protein Metabolic Process Protein Monoubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Canonical Wnt Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cellular Metabolic Process
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