MED31 and PABPC4

Number of citations of the paper that reports this interaction (PMID 15383276)
99

Data Source:
HPRD (two hybrid)

		MED31	PABPC4
Gene Name		mediator complex subunit 31	poly(A) binding protein, cytoplasmic 4 (inducible form)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mediator Complex	Nucleus Cytoplasm Cytoplasmic Stress Granule Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding Protein Complex Binding	Nucleotide Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Protein Complex Assembly Gene Expression Negative Regulation Of Fibroblast Proliferation Limb Development	RNA Processing RNA Catabolic Process Translation Blood Coagulation
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			C-reactive protein ( 21300955) HDL cholesterol ( 20686565)
Protein-Protein Interactions		58 interactors: AES AGR2 ANXA7 ASCC2 C2orf44 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 UBE2B ZBTB45 ZSCAN1	14 interactors: EEF1A1 GDF9 HAP1 IL7R MED31 PHLDA1 RIF1 SETDB1 SMAD9 SREK1 SRPK2 UBC XRN1 YWHAQ
Entrez ID		51003	8761
HPRD ID		14382	04557
Ensembl ID		ENSG00000108590	ENSG00000090621
Uniprot IDs		Q9Y3C7	B1ANR0 Q13310
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Developmental Process Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Differentiation Multicellular Organismal Development Response To Stimulus Neurotransmitter Uptake Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Telomere Maintenance Via Semi-conservative Replication System Development Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Cell Death Telomere Maintenance Via Recombination Nuclear DNA Replication Mitotic DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Embryo Development Ending In Birth Or Egg Hatching DNA-templated Transcription, Initiation Response To External Stimulus Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Protein Metabolic Process	RNA Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Transcription, DNA-templated Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Transcription, DNA-templated Developmental Process Nitrogen Compound Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Death Multicellular Organismal Development Regulation Of Metabolic Process Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Cell Cycle Nuclear Speck Organization Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly FasL Biosynthetic Process Organ Development Brain Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway System Development BMP Signaling Pathway Head Development Regulation Of ERBB Signaling Pathway Midbrain Development Interleukin-7-mediated Signaling Pathway Oocyte Growth Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cilium Assembly
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