MED31 and LYPLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED31	LYPLA2
Description		mediator complex subunit 31	lysophospholipase 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Nucleoplasm Cytoplasm Golgi Stack Cytosol Extracellular Exosome
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Phosphatidylcholine Lysophospholipase Activity Protein Binding Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity Cadherin Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation RNA Polymerase II Preinitiation Complex Assembly Limb Development Positive Regulation Of Transcription Initiation By RNA Polymerase II	Lipid Metabolic Process Fatty Acid Metabolic Process Axon Guidance Acylglycerol Catabolic Process Macromolecule Depalmitoylation Prostaglandin Catabolic Process
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	L1CAM interactions
Drugs
Diseases
GWAS		LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		58 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED8 MED9 MOB4 NAF1 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1	5 interacting genes: APP DKC1 INCA1 MED31 SCMH1
Entrez ID		51003	11313
HPRD ID		14382	07127
Ensembl ID		ENSG00000108590	ENSG00000011009
Uniprot IDs		Q9Y3C7	A0A140VJC9 O95372
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	5SYN 6BJE
Enriched GO Terms of Interacting Partners?		Nucleus Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Identical Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Protein Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA-templated Transcription Elongation Nucleoplasm	Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Box H/ACA SnoRNA Binding Protein Localization To Nucleoplasm SnRNA Pseudouridine Synthesis Protein Localization To Cajal Body Box H/ACA Sno(s)RNA Metabolic Process Box H/ACA SnoRNP Complex Box H/ACA Sno(s)RNA 3'-end Processing Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA ScaRNP Complex Telomerase RNA Stabilization Negative Regulation Of Fibroblast Proliferation Regulation Of Fibroblast Proliferation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Box H/ACA Telomerase RNP Complex ScaRNA Localization To Cajal Body Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway SnRNA Modification Telomerase Holoenzyme Complex Assembly Regulation Of Primary Metabolic Process
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