MED31 and LAMA4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED31	LAMA4
Description		mediator complex subunit 31	laminin subunit alpha 4
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Extracellular Region Basement Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation RNA Polymerase II Preinitiation Complex Assembly Limb Development Positive Regulation Of Transcription Initiation By RNA Polymerase II	Cell Adhesion Regulation Of Cell Adhesion Regulation Of Cell Migration Regulation Of Embryonic Development Negative Regulation Of Cold-induced Thermogenesis
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases
GWAS		LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	A body shape index ( 34021172) Bipolar disorder ( 31043756) Metabolite levels ( 23823483) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		58 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED8 MED9 MOB4 NAF1 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1	17 interacting genes: APC ATF7IP BRD7 COPS6 EEF1A1 FHL1 GAPDH LRIF1 MED31 PTN RTN4 RTP2 TP53 TUBB2A UBR1 UNC119 ZHX1
Entrez ID		51003	3910
HPRD ID		14382	02532
Ensembl ID		ENSG00000108590	ENSG00000112769
Uniprot IDs		Q9Y3C7	A0A0A0MTC7 Q16363 Q5D044
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Nucleus Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Identical Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Protein Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA-templated Transcription Elongation Nucleoplasm	Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Epigenetic Regulation Of Gene Expression Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Regulation Of Hepatocyte Proliferation Negative Regulation Of Neuroblast Proliferation Regulation Of Gliogenesis Leukocyte Migration Involved In Inflammatory Response Negative Regulation Of Cell Cycle Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Primary Metabolic Process Disordered Domain Specific Binding Negative Regulation Of Neural Precursor Cell Proliferation Molecular Function Activator Activity Nuclear Matrix Negative Regulation Of Neurogenesis Regulation Of Mitotic Cell Cycle Phase Transition Heterochromatin Formation Negative Regulation Of Nervous System Development Negative Regulation Of Cell Cycle Chromatin Remodeling Regulation Of Neurogenesis Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Growth Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Male Mating Behavior Dendrite Development Regulation Of Neuroblast Proliferation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Regulation Of Macromolecule Metabolic Process Regulation Of Nervous System Development Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Gene Expression, Epigenetic
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