CD274 and COPS5

Number of citations of the paper that reports this interaction (PubMedID 31802034)
44

Data Source:
BioGRID (enzymatic study, enzymatic study)

		CD274	COPS5
Description		CD274 molecule	COP9 signalosome subunit 5
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Endomembrane System Actin Cytoskeleton Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding Receptor Ligand Activity	Transcription Coactivator Activity Translation Initiation Factor Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity DeNEDDylase Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Metal-dependent Deubiquitinase Activity
	Biological Process	Adaptive Immune Response Immune System Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Response To Cytokine TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of DNA-templated Transcription Regulation Of Activated T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Activation Regulation Of T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation	Protein Deneddylation Translation Translational Initiation Proteolysis Negative Regulation Of Apoptotic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion Regulation Of Protein Neddylation
Pathways		Co-inhibition by PD-1 STAT3 nuclear events downstream of ALK signaling Regulation of PD-L1(CD274) translation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PD-L1(CD274) glycosylation and translocation to plasma membrane	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Drugs		Sildenafil Valproic acid Nivolumab Pembrolizumab Atezolizumab Durvalumab Avelumab Camrelizumab Envafolimab Cosibelimab AUNP-12 CA-170 anti-OX40 antibody BMS 986178
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		14 interacting genes: ANXA1 CD80 COPS5 CSNK2A1 DCAF1 HMGA1 HUWE1 ITGB1 OTUB1 PDCD1 TMUB1 UBQLN4 USP5 USP8	113 interacting genes: APCS APP ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 BRWD1 BTG3 CACNA1C CD274 CD93 CDKN1B CEBPA CENPT CFAP298 COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4B CUL5 DDB1 DDO DSCAM ERN1 ERRFI1 ESR1 F2RL1 GATD3 GFER GFI1B GPS1 GRIK1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 HUNK IKBKB ITGB2 JUN JUND LASP1 LCOR MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MORC3 MSRA MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 PUM1 PUM2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SIAH1 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 STAMBPL1 SUMO3 TOP2A TP53 TTC3 TXN TYK2 UCHL1 VTN WDR4 WNK1 YWHAG
Entrez ID		29126	10987
HPRD ID		05655	06888
Ensembl ID		ENSG00000120217	ENSG00000121022
Uniprot IDs		Q0GN75 Q9NZQ7	A0A024R7W9 Q92905
PDB IDs		3BIK 3BIS 3FN3 3SBW 4Z18 4ZQK 5C3T 5GGT 5GRJ 5IUS 5J89 5J8O 5JDR 5JDS 5N2D 5N2F 5NIU 5O45 5O4Y 5X8L 5X8M 5XJ4 5XXY 6L8R 6NM7 6NM8 6NNV 6NOJ 6NOS 6NP9 6PV9 6R3K 6RPG 6VQN 6YCR 7BEA 7C88 7CZD 7DCV 7DY7 7NLD 7OUN 7SJQ 7TPS 7UX5 7UXO 7UXP 7UXQ 7VUN 7XAD 7XAE 7XYQ 7YDS 8ALX 8AOK 8AOM 8JBA 8K5N 8OR1 8P1O 8R6Q 8RPB 8XR5 9INU	4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Protein Metabolic Process Negative Regulation Of T Cell Activation Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Double-strand Break Repair Protein Modification By Small Protein Removal Protein K48-linked Deubiquitination Proteolysis Negative Regulation Of DNA Repair Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of Leukocyte Cell-cell Adhesion DeNEDDylase Activity Negative Regulation Of Lymphocyte Activation Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cell-cell Adhesion Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Leukocyte Activation DNA Metabolic Process Protein Modification Process Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of Immune Response Negative Regulation Of Cell Activation Regulation Of Adaptive Immune Response Negative Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Negative Regulation Of Immune Response To Tumor Cell Cysteine-type Deubiquitinase Activity DNA Repair Negative Regulation Of Apoptotic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Deubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of T Cell Mediated Immunity Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Adhesion Regulation Of Metabolic Process Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Macromolecule Catabolic Process Cysteine-type Peptidase Activity Positive Regulation Of Metabolic Process Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of T-helper Cell Differentiation Proteolysis Involved In Protein Catabolic Process	Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Protein Deneddylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Neddylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Transcription Coactivator Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription MAPK Cascade Protein Modification Process Response To Stress Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Programmed Cell Death Cell Death Transcription Regulator Complex Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Protein-containing Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?