CD274 and CD80

Number of citations of the paper that reports this interaction (PMID 21982860)
4

Data Source:
BioGRID (pull down)

		CD274	CD80
Gene Name		CD274 molecule	CD80 molecule
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Endomembrane System Integral Component Of Membrane Extracellular Vesicular Exosome	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Protein Binding	Protein Binding Coreceptor Activity
	Biological Process	Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Proliferation Regulation Of Activated T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Regulation Of T Cell Apoptotic Process Toxin Transport Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Interleukin-10 Secretion	Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Viral Process T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Alpha-beta T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Pathways		Costimulation by the CD28 family PD-1 signaling Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Costimulation by the CD28 family Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CTLA4 inhibitory signaling CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CD28 dependent Vav1 pathway Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Abatacept Belatacept
Diseases
GWAS			Celiac disease ( 20190752) Primary biliary cirrhosis ( 23000144 21399635) Systemic lupus erythematosus ( 23273568) Vitiligo ( 22561518)
Protein-Protein Interactions		2 interactors: CD80 PDCD1	5 interactors: CD274 CD28 CD86 CTLA4 NGFR
Entrez ID		29126	941
HPRD ID		05655	00202
Ensembl ID		ENSG00000120217	ENSG00000121594
Uniprot IDs		Q0GN75 Q2V8D5 Q9NZQ7	A0N0P2 P33681
PDB IDs		3BIK 3BIS 3FN3 3SBW	1DR9 1I8L
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Cell Activation Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Cell Adhesion Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Immune System Process Positive Regulation Of Lymphocyte Apoptotic Process Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Apoptotic Process Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of T-helper Cell Differentiation Positive Regulation Of Interleukin-2 Production Immune Response Regulation Of Immune System Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of T Cell Apoptotic Process Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Immune System Process Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Phosphatidylinositol-mediated Signaling Regulation Of T Cell Proliferation Positive Regulation Of Adaptive Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway	T Cell Costimulation Regulation Of T Cell Proliferation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Proliferation Regulation Of Cell Activation Regulation Of Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of Interleukin-2 Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Neurotrophin Signaling Pathway Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-2 Production Regulation Of Activated T Cell Proliferation Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Negative Regulation Of T Cell Proliferation Immune Response-regulating Signaling Pathway Positive Regulation Of Cytokine Biosynthetic Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of Cytokine Production Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune Response Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of T Cell Anergy Positive Regulation Of Lymphotoxin A Biosynthetic Process Regulation Of Cytokine Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of T Cell Differentiation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion
Tagcloud ?		9p24 actionable arid1a atlas barr bystander cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite mlh1 msi noncoding pdcd1lg2 qualify	amixl atl bc blast burkitt cd54 cd58 cd86 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Difference) ?		9p24 actionable arid1a atlas barr bystander cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite mlh1 msi noncoding pdcd1lg2 qualify	amixl atl bc blast burkitt cd54 cd58 cd86 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Intersection) ?