CIT and RHOC

Number of citations of the paper that reports this interaction (PubMedID 8543060)
0

Data Source:
HPRD (two hybrid, in vitro)

		CIT	RHOC
Description		citron rho-interacting serine/threonine kinase	ras homolog family member C
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Nucleus Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Cleavage Furrow Stereocilium Extracellular Exosome
	Molecular Function	Nucleotide Binding Transcription Coactivator Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Nervous System Development Cell Differentiation Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Hippo Signaling Generation Of Neurons Cell Division Neuron Apoptotic Process	Mitotic Cytokinesis Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Apical Junction Assembly Wound Healing, Spreading Of Cells Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration
Pathways		RHO GTPases activate CIT RHO GTPases activate CIT RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOC GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Mitochondrial heteroplasmy measurement ( 33731350) Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: CEBPA DISC1 DLG4 DSCAM GRIN1 GRIN2D MTNR1A RAC1 RHOA RHOB RHOC RND3	8 interacting genes: ARHGAP1 CAV1 CIT DIAPH1 RIPOR2 RIPOR3 ROCK1 RTKN
Entrez ID		11113	389
HPRD ID		09289	01322
Ensembl ID		ENSG00000122966	ENSG00000155366
Uniprot IDs		O14578	A0A024R0C8 P08134
PDB IDs			1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Regulation Of Neuronal Synaptic Plasticity Intracellular Signaling Cassette Skeletal Muscle Satellite Cell Migration Intracellular Signal Transduction Cerebral Cortex Cell Migration Signal Transduction Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Small GTPase-mediated Signal Transduction Supramolecular Fiber Organization Telencephalon Cell Migration Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Lipase Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cleavage Furrow Positive Regulation Of Stress Fiber Assembly Forebrain Cell Migration Cell Adhesion Regulation Of System Process Apical Junction Assembly GTPase Activity GTP Binding Dendritic Spine Glutamatergic Synapse Negative Regulation Of Oxidative Phosphorylation Synapse Protein-containing Complex Binding Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission NMDA Glutamate Receptor Activity Glutamate Binding Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Multicellular Organismal Process Regulation Of Actin Filament-based Process Negative Regulation Of Cellular Respiration NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Synaptic Membrane Mitotic Cytokinesis Excitatory Chemical Synaptic Transmission Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Regulation Of Synaptic Transmission, Glutamatergic	Small GTPase Binding Rho Protein Signal Transduction Regulation Of Cytoskeleton Organization Mitotic Cytokinesis Cytoskeleton-dependent Cytokinesis Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signaling Cassette Negative Regulation Of Anoikis Actin Filament-based Process Regulation Of Anoikis Cell Death Apoptotic Process Programmed Cell Death Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Establishment Of Cell Polarity Membrane Raft Organization Cortical Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Actin-mediated Cell Contraction Regulation Of Cell Projection Assembly Regulation Of Organelle Organization Cortical Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process Inward Rectifier Potassium Channel Inhibitor Activity Actin Filament-based Movement Negative Regulation Of Establishment Of T Cell Polarity Negative Regulation Of Protein Localization To Cell Leading Edge Response To Peptide Hormone Response To Transforming Growth Factor Beta System Process Regulation Of Actin Cytoskeleton Organization Protein Serine Kinase Activity Regulation Of Cellular Component Organization Regulation Of Developmental Process Caveolar Macromolecular Signaling Complex Positive Regulation Of Myeloid Dendritic Cell Activation Rho-dependent Protein Serine/threonine Kinase Activity Septin Ring Organization Negative Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Regulation Of T Cell Activation Signaling Receptor Binding Protein Serine/threonine Kinase Activity Negative Regulation Of Endocytic Recycling Ruffle Positive Regulation Of Cell Junction Assembly Insulin Receptor Internalization Protein Localization To Basolateral Plasma Membrane
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