CIT and RHOB

Number of citations: 0 (PubMedID 8543060)
Data Source: BioGRID (far western blotting, two hybrid, proximity labelling technology, affinity chromatography technology)

		CIT	RHOB
Name		citron rho-interacting serine/threonine kinase	ras homolog family member B
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Nucleus Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Late Endosome Membrane Cleavage Furrow Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse
	Molecular Function	Nucleotide Binding Transcription Coactivator Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Nervous System Development Cell Differentiation Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Hippo Signaling Generation Of Neurons Cell Division Neuron Apoptotic Process	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Endosome To Lysosome Transport Positive Regulation Of Endothelial Cell Migration Protein Transport Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation Regulation Of Modification Of Postsynaptic Structure
Pathways		RHO GTPases activate CIT RHO GTPases activate CIT RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOB GTPase cycle
Drugs		Fostamatinib	Botulinum toxin type A
GWAS		Mitochondrial heteroplasmy measurement ( 33731350 ) Number of sexual partners ( 30643258 ) Urgency urinary incontinence ( 25524241 )	Systemic sclerosis ( 21750679 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )
Interacting Genes		12 interacting genes: CEBPA DISC1 DLG4 DSCAM GRIN1 GRIN2D MTNR1A RAC1 RHOA RHOB RHOC RND3	18 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PIAS1 PKN1 PPP2CA RHPN2 ROCK1 RTKN SMURF1 TNFAIP1 UBE2I ZKSCAN5
Entrez ID		11113	388
HPRD ID		09289	01321
Ensembl ID		ENSG00000122966	ENSG00000143878
Uniprot IDs		O14578	P62745
PDB IDs		Not available	2FV8 6HXU 6SGE
GO Terms Enriched among Interactors		Actin Filament Organization Regulation Of Neuronal Synaptic Plasticity Intracellular Signaling Cassette Skeletal Muscle Satellite Cell Migration Intracellular Signal Transduction Cerebral Cortex Cell Migration Signal Transduction Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Small GTPase-mediated Signal Transduction Supramolecular Fiber Organization Telencephalon Cell Migration Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Lipase Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cleavage Furrow Positive Regulation Of Stress Fiber Assembly Forebrain Cell Migration Cell Adhesion Regulation Of System Process Apical Junction Assembly GTPase Activity GTP Binding Dendritic Spine Glutamatergic Synapse Negative Regulation Of Oxidative Phosphorylation Synapse Protein-containing Complex Binding Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission NMDA Glutamate Receptor Activity Glutamate Binding Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Multicellular Organismal Process Regulation Of Actin Filament-based Process Negative Regulation Of Cellular Respiration NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Synaptic Membrane Mitotic Cytokinesis Excitatory Chemical Synaptic Transmission Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Regulation Of Synaptic Transmission, Glutamatergic	Rho Protein Signal Transduction CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Modification Process Protein Geranylgeranyltransferase Activity Cytosol Protein Prenyltransferase Activity Small GTPase Binding Protein Geranylgeranylation Tau Protein Binding Protein Prenylation Prenyltransferase Activity Transferase Activity Mitotic Cytokinesis GTPase Inhibitor Activity Cytoskeleton-dependent Cytokinesis Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process SUMO Transferase Activity Receptor Catabolic Process Positive Regulation Of Dendrite Extension Regulation Of Cytoskeleton Organization Post-translational Protein Modification Actomyosin Structure Organization Renal System Process Negative Regulation Of Hippo Signaling Apoptotic Process Cytoplasm Regulation Of Protein Localization Cell Death Programmed Cell Death Presynaptic Cytosol Postsynaptic Cytosol Cortical Actin Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Epithelial Cell Migration Regulation Of Signal Transduction Signal Transduction System Process Neuromuscular Junction Development Microtubule Associated Complex Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Cell Surface Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Supramolecular Fiber Organization Protein Modification By Small Protein Conjugation