PPFIA4 and CAST

Number of citations of the paper that reports this interaction (PubMedID 12923177)
0

Data Source:
HPRD (two hybrid, in vitro)

		PPFIA4	CAST
Description		PPFI scaffold protein A4	calpastatin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Surface Synapse Presynaptic Active Zone	Cytoplasm Endoplasmic Reticulum Cytosol Membrane
	Molecular Function	Protein Binding	RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Cadherin Binding
	Biological Process	Synapse Organization	Presynaptic Active Zone Organization Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			Calcium Artenimol
Diseases
GWAS		Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Atrial fibrillation ( 28416822 29892015 30061737) Early onset atrial fibrillation ( 28460022)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol dependence ( 19581569) Appendicular lean mass ( 33097823) Body mass index ( 26426971 29381148) Fish- and plant-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		6 interacting genes: AGTPBP1 CAST DNAJC5 ERC2 GIT1 NCOA2	11 interacting genes: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 SUMO2
Entrez ID		8497	831
HPRD ID		16012	00233
Ensembl ID		ENSG00000143847	ENSG00000310517
Uniprot IDs		A0A8J8YUZ5 B3KN22 B4DIS5 O75335	A0A6Q8PH20 B7Z6N0 E9PCH5 E9PDE4 P20810 Q59HE3 Q86YM9
PDB IDs
Enriched GO Terms of Interacting Partners?		Presynaptic Active Zone Organization Locomotory Behavior Maintenance Of Synapse Structure Presynapse Cell Junction Maintenance Cellular Component Maintenance Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of ARF Protein Signal Transduction Anterograde Axonal Transport Of Mitochondrion GABA-ergic Synapse Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Vesicle-mediated Transport Structural Constituent Of Postsynaptic Specialization Cellular Response To Thyroglobulin Triiodothyronine Retrograde Axonal Transport Of Mitochondrion C-terminal Protein Deglutamylation Growth Cone Protein Deglutamylation Protein Side Chain Deglutamylation Neuron Development Response To Thyroglobulin Triiodothyronine Negative Regulation Of Type B Pancreatic Cell Apoptotic Process RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Aryl Hydrocarbon Receptor Binding Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Intramembranous Ossification Positive Regulation Of Microtubule Nucleation Motor Learning ATP-dependent Protein Binding Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Synapse Organization Positive Regulation Of Receptor Catabolic Process Maintenance Of Postsynaptic Specialization Structure Negative Regulation Of Inflammatory Response To Wounding Cytoplasm Locomotor Rhythm Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Small Molecule Metabolic Process Positive Regulation Of Adipose Tissue Development Peptidyl-glutamic Acid Modification Cerebellar Purkinje Cell Layer Development Axonal Transport Of Mitochondrion Cerebellar Purkinje Cell Differentiation Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Presynaptic Active Zone Cytoplasmic Component Immunological Synapse Formation Dendritic Spine Development Regulation Of Inflammatory Response To Wounding	Presynaptic Active Zone Protein Poly-ADP-ribosylation Calpain Complex Cysteine-type Peptidase Activity Pyroptotic Inflammatory Response Cellular Response To Staurosporine Peptidase Activity Cysteine-type Endopeptidase Activity Synapse Organization Calcium-dependent Cysteine-type Endopeptidase Activity Fibroblast Apoptotic Process Proteolysis Interleukin-18-mediated Signaling Pathway Cytosol Aspartic-type Endopeptidase Activity Execution Phase Of Apoptosis Plasma Membrane Repair Cell Junction Organization Protein Processing Regulation Of Macroautophagy Cellular Response To Alkaloid Glutamatergic Synapse Cellular Response To Osmotic Stress Leukocyte Apoptotic Process Ceramide Biosynthetic Process Structural Constituent Of Presynapse Epididymosome Protein Metabolic Process Cytoplasm Protein Maturation Response To Lipopolysaccharide Positive Regulation Of Neuron Apoptotic Process Striated Muscle Cell Differentiation Response To Osmotic Stress Response To Molecule Of Bacterial Origin AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Phospholipase A2 Activator Activity Regulation Of Autophagy Ceramide Metabolic Process Post-translational Protein Modification Endopeptidase Activity Response To Alkaloid Sphingolipid Biosynthetic Process AIM2 Inflammasome Complex IPAF Inflammasome Complex Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Structural Constituent Of Postsynaptic Density Hydrolase Activity Cell Death
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