PPFIA4 and DNAJC5

Number of citations of the paper that reports this interaction (PubMedID 29997244)
64

Data Source:
BioGRID (fluorescent resonance energy transfer)

		PPFIA4	DNAJC5
Description		PPFI scaffold protein A4	DnaJ heat shock protein family (Hsp40) member C5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Surface Synapse Presynaptic Active Zone	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse
	Molecular Function	Protein Binding	Protein Binding ATP-dependent Protein Binding
	Biological Process	Synapse Organization	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Atrial fibrillation ( 28416822 29892015 30061737) Early onset atrial fibrillation ( 28460022)	Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		6 interacting genes: AGTPBP1 CAST DNAJC5 ERC2 GIT1 NCOA2	49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		8497	80331
HPRD ID		16012	08539
Ensembl ID		ENSG00000143847	ENSG00000101152
Uniprot IDs		A0A8J8YUZ5 B3KN22 B4DIS5 O75335	Q9H3Z4
PDB IDs			2N04 2N05
Enriched GO Terms of Interacting Partners?		Presynaptic Active Zone Organization Locomotory Behavior Maintenance Of Synapse Structure Presynapse Cell Junction Maintenance Cellular Component Maintenance Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of ARF Protein Signal Transduction Anterograde Axonal Transport Of Mitochondrion GABA-ergic Synapse Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Vesicle-mediated Transport Structural Constituent Of Postsynaptic Specialization Cellular Response To Thyroglobulin Triiodothyronine Retrograde Axonal Transport Of Mitochondrion C-terminal Protein Deglutamylation Growth Cone Protein Deglutamylation Protein Side Chain Deglutamylation Neuron Development Response To Thyroglobulin Triiodothyronine Negative Regulation Of Type B Pancreatic Cell Apoptotic Process RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Aryl Hydrocarbon Receptor Binding Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Intramembranous Ossification Positive Regulation Of Microtubule Nucleation Motor Learning ATP-dependent Protein Binding Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Synapse Organization Positive Regulation Of Receptor Catabolic Process Maintenance Of Postsynaptic Specialization Structure Negative Regulation Of Inflammatory Response To Wounding Cytoplasm Locomotor Rhythm Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Small Molecule Metabolic Process Positive Regulation Of Adipose Tissue Development Peptidyl-glutamic Acid Modification Cerebellar Purkinje Cell Layer Development Axonal Transport Of Mitochondrion Cerebellar Purkinje Cell Differentiation Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Presynaptic Active Zone Cytoplasmic Component Immunological Synapse Formation Dendritic Spine Development Regulation Of Inflammatory Response To Wounding	Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation
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