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PPFIA4 and NCOA2
Number of citations of the paper that reports this interaction (PMID
11931740
)
52
Data Source:
BioGRID
(two hybrid, pull down)
PPFIA4
NCOA2
Gene Name
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
nuclear receptor coactivator 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Cytosol
Cell Surface
Synapse
Presynaptic Active Zone
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Protein Binding
Chromatin Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Signal Transducer Activity
Protein Binding
Transcription Factor Binding
Ligand-dependent Nuclear Receptor Binding
Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Thyroid Hormone Receptor Coactivator Activity
Nuclear Hormone Receptor Binding
Protein Dimerization Activity
Biological Process
Synaptic Transmission
Neurotransmitter Secretion
Glutamate Secretion
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Glucose Metabolic Process
Histone Acetylation
Intracellular Receptor Signaling Pathway
Cellular Response To Hormone Stimulus
Circadian Regulation Of Gene Expression
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Receptor Activity
Pathways
Dopamine Neurotransmitter Release Cycle
Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Serotonin Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Transmission across Chemical Synapses
PPARA activates gene expression
Bile acid and bile salt metabolism
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Organelle biogenesis and maintenance
Metabolism of lipids and lipoproteins
Metabolic disorders of biological oxidation enzymes
Phase 1 - Functionalization of compounds
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
RORA activates circadian gene expression
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Generic Transcription Pathway
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Cytochrome P450 - arranged by substrate type
Endogenous sterols
Transcriptional regulation of white adipocyte differentiation
Biological oxidations
Synthesis of bile acids and bile salts
Orphan transporters
Defective FMO3 causes Trimethylaminuria (TMAU)
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Fatty acid, triacylglycerol, and ketone body metabolism
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Recycling of bile acids and salts
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REV-ERBA represses gene expression
Defective CYP1B1 causes Glaucoma
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Mitochondrial biogenesis
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Activation of gene expression by SREBF (SREBP)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional activation of mitochondrial biogenesis
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Cardiac Troponin-T levels (
23247143
)
Metabolite levels (HVA-5-HIAA Factor score) (
23319000
)
Non-small cell lung cancer (
23144319
)
Protein-Protein Interactions
5 interactors:
AGTPBP1
CAST
ERC2
GIT1
NCOA2
63 interactors:
ACTN2
AHR
ANKRD11
AR
ARNT
BRCA1
CARM1
CCND3
CCNT1
CDK4
CREBBP
CTNNB1
DDX17
DDX5
DLX2
DLX5
EID1
EP300
ESR1
ESR2
ESRRB
ETV1
FOS
GMEB1
HIF1A
HIST3H3
HIST4H4
HNF4A
JUN
KIF5A
KIF5B
KIF5C
MAGEA11
MEF2C
NKX2-1
NR1I2
NR3C1
NR4A1
OPN1LW
PIAS3
PML
PPARA
PPARD
PPARG
PPFIA1
PPFIA4
PRMT1
PSMB9
RARA
RORA
RXRA
SLC30A9
SMARCE1
SRA1
SRCAP
STAT6
SUMO1
TAF9
THRB
TP53
TXNRD2
VDR
YWHAH
Entrez ID
8497
10499
HPRD ID
16012
09066
Ensembl ID
ENSG00000143847
ENSG00000140396
Uniprot IDs
B3KN22
O75335
Q15596
PDB IDs
1GWQ
1GWR
1M2Z
1MV9
1MVC
1MZN
1P93
1T63
1T65
1UHL
1YOK
1ZDT
1ZDU
1ZKY
2AO6
2B1V
2B1Z
2B23
2FAI
2G44
2G5O
2P15
2P1T
2P1U
2P1V
2Q7J
2Q7L
2ZXZ
2ZY0
3A9E
3CLD
3DZU
3DZY
3E00
3E7C
3E94
3FUG
3GN8
3K22
3K23
3KWY
3KYT
3L0E
3L0J
3L0L
3O1D
3O1E
3OAP
3OZJ
3PCU
3PLZ
3Q95
3Q97
3R5M
3UP0
3UP3
4DOS
4E2J
4FHH
4FHI
4IA1
4IA2
4IA3
4IA7
4IQR
4IU7
4IUI
4IV2
4IV4
4IVW
4IVY
4IW6
4IW8
4IWC
4IWF
Enriched GO Terms of Interacting Partners
?
Intracellular Receptor Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Transcription From RNA Polymerase II Promoter
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of RNA Metabolic Process
Steroid Hormone Mediated Signaling Pathway
Regulation Of Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
DNA-templated Transcription, Initiation
Gene Expression
Hormone-mediated Signaling Pathway
Positive Regulation Of Metabolic Process
RNA Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Cellular Response To Steroid Hormone Stimulus
Response To Steroid Hormone
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Response To Organic Cyclic Compound
Negative Regulation Of Transcription, DNA-templated
Response To Organic Cyclic Compound
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Response To Hormone
Response To Lipid
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Response To Organic Substance
Anatomical Structure Development
Developmental Process
Multicellular Organismal Development
Biosynthetic Process
Cellular Response To Hormone Stimulus
Cellular Response To Organic Substance
Tagcloud
?
bioenergy
causally
clearer
clinicopathologies
colonize
coregulator
coregulators
decidual
decidualization
decidualize
dovetailing
endometriotic
evade
glycolytic
launch
minireview
ncoa1
ncoa3
p160
pacemaker
pathobiology
pleiotropy
proposal
quiescence
subfecundity
tantalizing
triad
underexplored
underpinning
Tagcloud (Difference)
?
bioenergy
causally
clearer
clinicopathologies
colonize
coregulator
coregulators
decidual
decidualization
decidualize
dovetailing
endometriotic
evade
glycolytic
launch
minireview
ncoa1
ncoa3
p160
pacemaker
pathobiology
pleiotropy
proposal
quiescence
subfecundity
tantalizing
triad
underexplored
underpinning
Tagcloud (Intersection)
?