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C8orf33 and DVL3
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
C8orf33
DVL3
Gene Name
chromosome 8 open reading frame 33
dishevelled segment polarity protein 3
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Molecular Function
Protease Binding
Receptor Binding
Frizzled Binding
Protein Binding
Beta-catenin Binding
Protein Heterodimerization Activity
Biological Process
Positive Regulation Of Protein Phosphorylation
Outflow Tract Septum Morphogenesis
Wnt Signaling Pathway
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Non-canonical Wnt Signaling Pathway Via JNK Cascade
Response To Drug
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT mediated activation of DVL
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
negative regulation of TCF-dependent signaling by DVL-interacting proteins
Signaling by Wnt
Signaling by WNT in cancer
PCP/CE pathway
beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Major depressive disorder (
22472876
)
Protein-Protein Interactions
41 interactors:
AAMP
ALAS1
APP
BLOC1S2
BRD4
CEP70
CRELD2
DVL3
EDRF1
EPS8
FAM9B
FEZ1
FST
FYN
GIT1
GPRASP1
HAP1
HMBOX1
IKZF1
IMMT
KBTBD7
KCTD6
KRTAP10-7
LZTS2
MDFI
MRFAP1
NGEF
NOL7
PI4KA
PNMA1
RASSF1
SF3B2
TAOK1
TRIM23
TUBA1A
TUBB2B
WIZ
ZC3H15
ZFP28
ZNF205
ZNF331
48 interactors:
ADAP1
AXIN1
BAHD1
C8orf33
CCNK
CSNK1D
CSNK1E
CSNK2A1
CTNNB1
DAB2
DIDO1
DPPA2
DVL1
ENKD1
FAM13C
KAT7
KLF3
KLHL12
LNX1
LRRK2
LY6H
MARK2
MATN2
NKD1
NOL12
NXF1
PIK3CB
PITX1
PLN
PPM1A
PPP2CA
PRPF3
PSMF1
RPS10
RWDD2B
SNX22
STOM
SYT6
TNFAIP8L1
UTP3
VANGL1
WT1
YTHDC1
ZBTB48
ZNF264
ZNF408
ZNF512B
ZNF697
Entrez ID
65265
1857
HPRD ID
07951
03222
Ensembl ID
ENSG00000182307
ENSG00000161202
Uniprot IDs
Q9H7E9
Q92997
PDB IDs
Enriched GO Terms of Interacting Partners
?
Cell Cycle
Regulation Of Signal Transduction
Movement Of Cell Or Subcellular Component
Positive Regulation Of Metabolic Process
Cytoskeleton-dependent Intracellular Transport
Regulation Of Signaling
Axon Cargo Transport
Regulation Of Cell Cycle Process
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Mitotic Cell Cycle
Cell Cycle Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Gene Expression
Axon Guidance
Positive Regulation Of Cell Cycle Process
Locomotion
Positive Regulation Of Signal Transduction
Ephrin Receptor Signaling Pathway
Regulation Of Cellular Process
Regulation Of Cell Morphogenesis
Protein Polymerization
Regulation Of Metabolic Process
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of JNK Cascade
Positive Regulation Of Cell Cycle
Microtubule-based Process
Anterograde Axon Cargo Transport
Positive Regulation Of Intracellular Signal Transduction
Cellular Response To Stimulus
Axonogenesis
Microtubule-based Transport
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Neuron Projection Development
Intracellular Signal Transduction
Cell Projection Organization
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
System Development
Cellular Protein Complex Assembly
Generation Of Neurons
Positive Regulation Of Neutrophil Differentiation
Positive Regulation Of Neurotrophin Production
Positive Regulation Of Nonmotile Primary Cilium Assembly
Positive Regulation Of Hydrogen Peroxide Biosynthetic Process
Signal Transduction
Chemotaxis
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Wnt Signaling Pathway
Positive Regulation Of Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Gene Expression
RNA Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Wnt Signaling Pathway
RNA Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Transcription, DNA-templated
Nitrogen Compound Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Negative Regulation Of Signaling
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Signal Transduction
Regulation Of Cell Morphogenesis
Regulation Of Proteolysis
Regulation Of Cellular Component Organization
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Protein Modification Process
Macromolecule Biosynthetic Process
Negative Regulation Of Binding
Regulation Of Gene Expression
Cellular Metabolic Process
Regulation Of Protein Kinase Activity
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Positive Regulation Of Transferase Activity
Regulation Of Transcription, DNA-templated
Regulation Of Kinase Activity
Protein Complex Assembly
Tagcloud
?
achieves
adaptor
analogous
blockade
dab2
encouraging
erks
grb2
igfi
igfir
influencing
insufficient
links
mek
nonredundant
pharmacologic
postreceptor
relied
responded
sensitization
sensitizing
sevenless
shc
son
sos
synergized
tracked
unselected
Tagcloud (Difference)
?
achieves
adaptor
analogous
blockade
dab2
encouraging
erks
grb2
igfi
igfir
influencing
insufficient
links
mek
nonredundant
pharmacologic
postreceptor
relied
responded
sensitization
sensitizing
sevenless
shc
son
sos
synergized
tracked
unselected
Tagcloud (Intersection)
?