SRRT and CHD3

Number of citations of the paper that reports this interaction (PubMedID 28977666)
121

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		SRRT	CHD3
Description		serrate, RNA effector molecule	chromodomain helicase DNA binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body Protein-containing Complex Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytoskeleton NuRD Complex PML Body Centriolar Satellite
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Protein-macromolecule Adaptor Activity MRNA Cap Binding Complex Binding	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding Metal Ion Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing Response To Arsenic-containing Substance Positive Regulation Of Neurogenesis Neuronal Stem Cell Population Maintenance	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Spindle Organization Centrosome Cycle Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Stem Cell Differentiation
Pathways		RNA polymerase II transcribes snRNA genes mRNA Splicing - Major Pathway Nuclear RNA decay	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Hemoglobin levels ( 32327693) Liver enzyme levels (alkaline phosphatase) ( 33972514) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Resting heart rate ( 27798624) RR interval (heart rate) ( 30679814)	Ischemic stroke ( 26089329) Macular thickness ( 30535121) Prostate cancer ( 29892016) Refractive error ( 32231278) Stroke ( 26089329)
Interacting Genes		16 interacting genes: APP CACNA1C CHD3 CSNK2A1 GEMIN4 GIT1 HNRNPK HSPA8 HTR6 IMMT LINC00624 SNRPF STAT3 SUMO2 VAV2 VIM	101 interacting genes: ACTR1B ADH5 AIMP2 ATP5IF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CBX4 CPE CRCT1 CREB1 CREBBP CSTF2 CTBP1 CTTN ENTR1 ETV5 FABP4 FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B HABP4 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MX1 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RETREG2 RGS2 RIF1 RNF10 RPL29 SAFB SAT1 SATB1 SERBP1 SERF2 SETX SGSM2 SIRT6 SKIL SLC27A6 SPOP SRRT STIP1 SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TRIM54 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBC UBE2I UROD VIM XRCC4 YAE1 ZHX1
Entrez ID		51593	1107
HPRD ID		10665	09071
Ensembl ID		ENSG00000087087	ENSG00000170004
Uniprot IDs		Q9BXP5	A0A8V8TR54 B3KWV4 Q12873 Q2TAZ1
PDB IDs		5OO6 6F7J 6F7P 6F7S 6F8D 8PMP
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Import Regulation Of Glycolytic Process MRNA Metabolic Process Regulation Of Carbohydrate Catabolic Process RNA Binding Negative Regulation Of Inflammatory Response To Wounding Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Inflammatory Response To Wounding Protein Targeting To Vacuole Involved In Autophagy Regulation Of Interleukin-1 Beta Production Small Nuclear Ribonucleoprotein Complex Positive Regulation Of Catabolic Process SMN-Sm Protein Complex Regulation Of Interleukin-1 Production PML Body Negative Regulation Of Glycolytic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of ATP Metabolic Process RNA Splicing Astrocyte Differentiation Positive Regulation Of ATP Metabolic Process Spliceosomal Complex Focal Adhesion MRNA Processing Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Dendrite Amylin Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Toll Signaling Pathway RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Chaperone-mediated Autophagy Translocation Complex Disassembly Spliceosomal SnRNP Assembly Negative Regulation Of ARF Protein Signal Transduction Protein Targeting To Vacuole Regulation Of Biological Quality RNA Metabolic Process Presynapse Postsynapse Regulation Of Cellular Response To Stress Positive Regulation Of Interleukin-1 Beta Production Acetylcholine Receptor Activator Activity Regulation Of Multicellular Organism Growth Lipoprotein Particle Positive Regulation Of Protein Import	Nucleoplasm Nucleus Negative Regulation Of Transcription By RNA Polymerase II Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process SUMO Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process PML Body Protein Sumoylation Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Programmed Cell Death RNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Ubiquitin Protein Ligase Binding Regulation Of Cell Development Presynaptic Cytosol Postsynaptic Cytosol Enzyme Binding Positive Regulation Of Metabolic Process Nucleic Acid Metabolic Process Nuclear Speck Regulation Of Neurogenesis Macromolecule Metabolic Process DNA Repair Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gliogenesis Protein-containing Complex Regulation Of Proteolysis Positive Regulation Of Neuron Apoptotic Process Regulation Of Cellular Response To Stress Regulation Of Cell Differentiation Transcription Corepressor Activity Promoter-specific Chromatin Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?