UTP23 and NHP2

Number of citations of the paper that reports this interaction (PubMedID 28082392)
37

Data Source:
BioGRID (pull down)

		UTP23	NHP2
Description		UTP23 small subunit processome component	NHP2 ribonucleoprotein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Small-subunit Processome	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cajal Body Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding MRNA 5'-UTR Binding Small Ribosomal Subunit RRNA Binding	RNA Binding MRNA 3'-UTR Binding Protein Binding U3 SnoRNA Binding Box H/ACA SnoRNA Binding Telomerase RNA Binding
	Biological Process	Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Ribosome Biogenesis	SnoRNA Guided RRNA Pseudouridine Synthesis RRNA Processing Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Ribosome Biogenesis Telomerase RNA Localization To Cajal Body
Pathways			Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases			Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS			Platelet count ( 29403010)
Interacting Genes		31 interacting genes: APP CYSRT1 DDX52 FCF1 GOLGA2 GRN KRT31 KRT34 KRT38 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 MEOX2 MID2 NBPF19 NFKBID NHP2 NOTCH2NLA PDE9A RRP7A SNHG3 TCF4 TEPSIN TRAF2 TRIB3 TRIM23 TRIM27	10 interacting genes: IKBKG JMJD6 MYL2 NEDD4 NEDD4L NOS1AP PRNP RSPH1 UBE2I UTP23
Entrez ID		84294	55651
HPRD ID		17499	07570
Ensembl ID		ENSG00000147679	ENSG00000145912
Uniprot IDs		Q9BRU9	J3QSY4 Q9NX24
PDB IDs			7BGB 7TRC 7V9A 8OUE 8OUF
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Astrocyte Activation Involved In Immune Response Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Supramolecular Fiber Organization Structural Molecule Activity Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Astrocyte Activation Regulation Of Autophagy RRNA Processing Regulation Of Viral Transcription	Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Sodium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Regulation Of Metal Ion Transport Transmembrane Transporter Binding Receptor Catabolic Process Regulation Of Monoatomic Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Postsynaptic Cytosol Negative Regulation Of Potassium Ion Transport Cytosol Neuromuscular Junction Development Regulation Of Membrane Repolarization Receptor Metabolic Process Regulation Of T Cell Receptor Signaling Pathway Muscle Cell Fate Specification Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Type 8 Metabotropic Glutamate Receptor Binding SUMO Conjugating Enzyme Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Cellular Component Assembly Signaling Adaptor Activity Channel Inhibitor Activity Ubiquitin Ligase Complex Regulation Of Membrane Potential Phosphothreonine Residue Binding Negative Regulation Of Monoatomic Ion Transport Regulation Of Dendrite Development RING-like Zinc Finger Domain Binding Linear Polyubiquitin Binding Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Protein Homooligomerization
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