UTP23 and FCF1

Number of citations of the paper that reports this interaction (PubMedID 28082392)
37

Data Source:
BioGRID (pull down)

		UTP23	FCF1
Description		UTP23 small subunit processome component	FCF1 rRNA-processing protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Small-subunit Processome	Nucleus Nucleoplasm Nucleolus Small-subunit Processome
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding MRNA 5'-UTR Binding Small Ribosomal Subunit RRNA Binding	RNA Binding Protein Binding
	Biological Process	Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Ribosome Biogenesis	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis
Pathways			rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Anxiety ( 33859377) Depression ( 33859377) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		31 interacting genes: APP CYSRT1 DDX52 FCF1 GOLGA2 GRN KRT31 KRT34 KRT38 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 MEOX2 MID2 NBPF19 NFKBID NHP2 NOTCH2NLA PDE9A RRP7A SNHG3 TCF4 TEPSIN TRAF2 TRIB3 TRIM23 TRIM27	4 interacting genes: APP BCCIP SPDYC UTP23
Entrez ID		84294	51077
HPRD ID		17499	12633
Ensembl ID		ENSG00000147679	ENSG00000119616
Uniprot IDs		Q9BRU9	G3V1S4 Q4FZ45 Q9Y324
PDB IDs			7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Astrocyte Activation Involved In Immune Response Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Supramolecular Fiber Organization Structural Molecule Activity Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Astrocyte Activation Regulation Of Autophagy RRNA Processing Regulation Of Viral Transcription	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Kinase Regulator Activity Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Small Ribosomal Subunit RRNA Binding Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
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