CXCL5 and NOTCH2NL

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CXCL5	NOTCH2NL
Gene Name		chemokine (C-X-C motif) ligand 5	notch 2 N-terminal like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Cytoplasm
	Molecular Function	Chemokine Activity CXCR Chemokine Receptor Binding	Calcium Ion Binding
	Biological Process	Neutrophil Mediated Immunity Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Response To Lipopolysaccharide Cell Chemotaxis Chemokine-mediated Signaling Pathway	Notch Signaling Pathway Multicellular Organismal Development Cell Differentiation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037)
Protein-Protein Interactions		5 interactors: ACKR1 CXCR1 CXCR2 MMP9 NOTCH2NL	241 interactors: ACY3 ADAMTSL3 ADAMTSL5 ADCK5 AES ALDH3B1 ALPI AQP1 AQP5 ARID3A ASPSCR1 ATG9A BCL6B BLCAP BMP7 C11orf87 C16orf59 C19orf66 C5orf60 CA6 CARHSP1 CARKD CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A COL8A1 CRACR2A CRCT1 CREB5 CSF1 CST2 CST9L CTSG CTSZ CXCL16 CXCL5 DGCR6 DHRS1 DMRT3 DNAL4 DOCK2 EFNA3 EIF4E2 ELANE EPHB6 ESR2 FAAH FAM124B FAM71C FAM71E2 FAM74A4 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 HBZ HCK HIST1H2AK HOXA1 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL2RG INPP5D ITGB2 ITGB5 JOSD1 KCTD15 KIF1A KLHL38 KLK8 KRT20 KRT83 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP13-3 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LIMS2 LIN7A LINC00526 LINC00656 LMO2 LNX1 LONRF3 LRCH4 LRFN4 MAPKBP1 MARK4 MATN3 MFI2 MRGBP MRPL40 MTA1 MVP MXD3 MXI1 NAB2 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NUBP2 P2RX4 PCED1A PCED1B PCSK5 PDE9A PGLS PID1 PIGS PLSCR4 POLR2G POM121L8P POMGNT2 PPAP2C PRKAA2 PRPF31 PRPS2 PSMA1 PSMG2 PTGER3 PTPMT1 PTPN23 PVR PVRL2 PVRL3 QPRT R3HDM2 RAB3IL1 RAMP3 RCHY1 RECK RET RGL2 RPS28 RTN4RL1 SCNM1 SDCBP SELM SEMA4C SLC22A23 SLC23A1 SLC25A10 SLC25A6 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA8 SPG7 SPINK2 SPRY1 STK16 TBC1D10C TBC1D16 THAP7 THEMIS2 TINAGL1 TMEM150A TMEM231 TMEM41A TNIP3 TNK2 TNP2 TRIM27 TRIM42 TRPV6 TSPAN4 TXNDC5 UBQLN4 UTP23 UXT WDR25 WT1-AS XCL2 YIPF3 ZFYVE21 ZNF124 ZNF32 ZNF417 ZNF439 ZNF440 ZNF446 ZNF581 ZNF587
Entrez ID		6374	388677
HPRD ID		08976	14833
Ensembl ID		ENSG00000163735	ENSG00000213240
Uniprot IDs		P42830 Q6I9S7	Q7Z3S9
PDB IDs
Enriched GO Terms of Interacting Partners?		Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway Dendritic Cell Chemotaxis Leukocyte Migration Dendritic Cell Migration Receptor Internalization Cell Surface Receptor Signaling Pathway Inflammatory Response Cytokine-mediated Signaling Pathway Receptor Metabolic Process Cellular Response To Cytokine Stimulus Chemotaxis Leukocyte Chemotaxis Negative Regulation Of Neutrophil Apoptotic Process Response To Cytokine Cell Migration Cell Chemotaxis Cell Motility Signal Transduction Signaling Positive Regulation Of Receptor Binding Cell Communication Positive Regulation Of Keratinocyte Migration G-protein Coupled Receptor Signaling Pathway Acute Inflammatory Response To Antigenic Stimulus Locomotion Defense Response Cellular Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Vascular Permeability Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Metanephric Tubule Morphogenesis Positive Regulation Of Locomotion Receptor-mediated Endocytosis Movement Of Cell Or Subcellular Component Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Response To External Stimulus Negative Regulation Of Cation Channel Activity Macrophage Differentiation Cellular Response To Organic Substance Positive Regulation Of Neutrophil Chemotaxis Neutrophil Activation Positive Regulation Of Granulocyte Chemotaxis Response To Stimulus Regulation Of Neutrophil Chemotaxis Metanephric Epithelium Development Regulation Of Neutrophil Migration Regulation Of Cell Migration	Developmental Process Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Locomotion Negative Regulation Of Biosynthetic Process Multicellular Organismal Development Response To Lipid Cell Motility Cellular Response To Lipid Movement Of Cell Or Subcellular Component Response To Lipopolysaccharide Positive Regulation Of Immune Response To Tumor Cell RNA Biosynthetic Process Transcription, DNA-templated System Development Response To Molecule Of Bacterial Origin Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To External Stimulus Susceptibility To T Cell Mediated Cytotoxicity Formation Of Primary Germ Layer Cellular Response To Stimulus Cellular Process Negative Regulation Of Transcription, DNA-templated Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Protein Metabolic Process Biosynthetic Process Endodermal Cell Differentiation Cell Migration Regulation Of Metabolic Process Regulation Of Cellular Process Response To Stimulus Gene Expression Nitrogen Compound Metabolic Process Organ Development Keratinization Anatomical Structure Morphogenesis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Neutrophil Mediated Immunity Extracellular Matrix Organization Extracellular Structure Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Carbon Dioxide Transport Gastrulation Cellular Macromolecule Biosynthetic Process Tissue Development Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Tagcloud ?		act1 alpha blot ccl20 changed chemokine chemokines cultured cxcl1 cxcl2 cxcl6 declined ht il intestinal knockdown line neutrophil obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf	a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures
Tagcloud (Difference) ?		act1 alpha blot ccl20 changed chemokine chemokines cultured cxcl1 cxcl2 cxcl6 declined ht il intestinal knockdown line neutrophil obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf	a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures
Tagcloud (Intersection) ?