CXCL5 and CXCL2

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CXCL5	CXCL2
Description		C-X-C motif chemokine ligand 5	C-X-C motif chemokine ligand 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Identical Protein Binding CXCR Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity
	Biological Process	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide	Response To Molecule Of Bacterial Origin Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Killing Of Cells Of Another Organism Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		CXCL5 levels ( 25147954) Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Urate levels (BMI interaction) ( 25811787)	Basophil percentage of white cells ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494 29403010) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 29403010 27863252 21738479) White blood cell types ( 21738478)
Interacting Genes		20 interacting genes: ACKR1 ACTN3 ALPP CCL11 CCL20 CXCL1 CXCL14 CXCL2 CXCL3 CXCR1 CXCR2 EFEMP2 FBLN1 GRN MEOX2 MGAT5B MMP9 NOTCH2NLA VWC2L XCL2	19 interacting genes: CCL11 CCL21 CCL28 CCL5 CCL8 CXCL11 CXCL12 CXCL14 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 EPS8 PF4 PIK3R1 PLG XCL1 XCL2
Entrez ID		6374	2920
HPRD ID		08976	00741
Ensembl ID		ENSG00000163735	ENSG00000081041
Uniprot IDs		P42830 Q6I9S7	P19875
PDB IDs		2MGS 8XWS 8XX7	1QNK 5OB5 8XVU 8XXH
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Cytokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Killing Of Cells Of Another Organism Humoral Immune Response Cell Migration Chemokine-mediated Signaling Pathway Extracellular Region Cell Killing Cell Motility Inflammatory Response Extracellular Space Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Granulocyte Chemotaxis C-C Chemokine Binding Immune Response Granulocyte Migration Interleukin-8 Binding Leukocyte Migration Defense Response Elastic Fiber Defense Response To Symbiont Myeloid Leukocyte Migration Immune System Process Defense Response To Other Organism Embryo Implantation Leukocyte Chemotaxis Signal Transduction Positive Regulation Of Cell Migration Neutrophil Chemotaxis C-X-C Chemokine Receptor Activity Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Neutrophil Migration Response To External Biotic Stimulus Regulation Of Cell Migration Cytokine-mediated Signaling Pathway Regulation Of Cell Motility Regulation Of Locomotion Response To Other Organism Dendritic Cell Chemotaxis G Protein-coupled Receptor Signaling Pathway Mononuclear Cell Migration Chemokine Receptor Activity C-C Chemokine Receptor Activity	Chemokine Activity Leukocyte Migration Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Leukocyte Chemotaxis Chemotaxis Antimicrobial Humoral Response Cell Migration Locomotion Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Motility Granulocyte Migration Cytokine Activity Humoral Immune Response Cytokine-mediated Signaling Pathway Immune System Process Immune Response Mononuclear Cell Migration Defense Response To Symbiont Defense Response To Other Organism Cell Killing Killing Of Cells Of Another Organism Neutrophil Chemotaxis Inflammatory Response CXCR Chemokine Receptor Binding Defense Response Neutrophil Migration Response To Other Organism Response To External Biotic Stimulus G Protein-coupled Receptor Signaling Pathway CCR Chemokine Receptor Binding Chemokine Receptor Binding Extracellular Space Dendritic Cell Migration Extracellular Region Signal Transduction Cell-cell Signaling Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Stress Dendritic Cell Chemotaxis Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell Motility Negative Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Locomotion Eosinophil Chemotaxis
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