SNRNP48 and SRSF8

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SNRNP48	SRSF8
Description		small nuclear ribonucleoprotein U11/U12 subunit 48	serine and arginine rich splicing factor 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Cytosol	Nucleus Nucleoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	MRNA Processing RNA Splicing	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Minor Pathway	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Height ( 31562340) Obesity-related traits ( 23251661)	Chronic widespread musculoskeletal pain ( 33331911)
Interacting Genes		14 interacting genes: CDCA7L ENKD1 EXOSC7 GPX4 GRN HUNK LUC7L2 MRPS27 PRPF6 SRSF8 SUPT5H TFIP11 UBASH3A UTP14A	24 interacting genes: APP CLK1 CLK2 CLK3 EIF4ENIF1 FOXP1 H19 KRTAP12-2 LUC7L LUC7L2 NXF1 PRPF38A PRPF6 RBM26 SNRNP48 SNRPA SREK1 SRPK1 SRPK2 SRSF3 ST13 TRA2B UBC WDR83
Entrez ID		154007	10929
HPRD ID		12858	04466
Ensembl ID		ENSG00000168566	ENSG00000263465
Uniprot IDs		Q6IEG0	Q9BRL6
PDB IDs		2VY4 2VY5 8R7N 8Y6O 9GBW 9GC0 9GCL	2DNM
Enriched GO Terms of Interacting Partners?		RNA Binding Nuclear Speck	RNA Splicing Nuclear Speck MRNA Processing RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Spliceosomal Complex RNA Processing MRNA Binding U1 SnRNP Nucleus Protein Serine/threonine/tyrosine Kinase Activity RNA Metabolic Process MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleoplasm Spliceosomal Complex Assembly Regulation Of MRNA Metabolic Process Nucleic Acid Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Nucleic Acid Metabolic Process U2-type Prespliceosome Pre-mRNA Binding Macromolecule Metabolic Process Protein Kinase Activity Protein Tyrosine Kinase Activity Nuclear Export Positive Regulation Of Viral Genome Replication MRNA Splice Site Recognition Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Kinase Activity Protein Phosphorylation Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Phosphorylation Identical Protein Binding Negative Regulation Of Viral Genome Replication U2-type Precatalytic Spliceosome Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import
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