CRY1 and PLSCR1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		CRY1	PLSCR1
Gene Name		cryptochrome circadian clock 1	phospholipid scramblase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion	Nucleus Nucleolus Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Matrix Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding Transcription Factor Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding Core Promoter Binding DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Transcription Factor Binding Blue Light Photoreceptor Activity Protein Kinase Binding Phosphatase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Ubiquitin Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding CD4 Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gluconeogenesis DNA Repair Transcription, DNA-templated DNA Damage Induced Protein Phosphorylation Circadian Rhythm Blue Light Signaling Pathway Protein-chromophore Linkage Lipid Storage Negative Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of DNA Damage Checkpoint Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucocorticoid Secretion	Phosphatidylserine Biosynthetic Process Apoptotic Process Acute-phase Response Positive Regulation Of Gene Expression Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ARNTL CBLB CSNK1E GRN KRTAP4-12 LTBP4 MDFI PER1 PER2 PER3 PLSCR1 SNRPD3 TIMELESS TRAF2 USP2	125 interactors: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf10 C10orf54 C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF3L CPSF6 CRK CRKL CRY1 CTBP1-AS2 CTSZ DAZAP2 DEF6 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM103A1 FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 IP6K2 KIAA1683 KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PRKCD PRR13 RASD1 RBL1 RERE RGS3 SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG TRAF4 TRIM42 VASP VPS37C YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF764
Entrez ID		1407	5359
HPRD ID		09050	08855
Ensembl ID		ENSG00000008405	ENSG00000188313
Uniprot IDs		A2I2P0 Q16526	B4DTE8 O15162
PDB IDs			1Y2A
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Circadian Regulation Of Translation Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Response To Stimulus Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Hair Cycle Photoperiodism Entrainment Of Circadian Clock Regulation Of JNK Cascade Signal Transduction Cellular Response To Stimulus Cellular Metabolic Process Transcription, DNA-templated Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Transcription, DNA-templated Histone H3 Deacetylation Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Signaling Regulation Of RNA Metabolic Process Cell Communication Negative Regulation Of Signal Transduction Negative Regulation Of DNA Binding Regulation Of Protein Transport Negative Regulation Of Signaling Regulation Of Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Regulation Of Nitrogen Compound Metabolic Process	Regulation Of Nitrogen Compound Metabolic Process Organ Development RNA Metabolic Process Transcription, DNA-templated Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Gene Expression Developmental Process RNA Biosynthetic Process Multicellular Organismal Development Regulation Of Protein Kinase Activity Regulation Of Transcription, DNA-templated Regulation Of Signaling Cellular Response To Organic Substance ERBB Signaling Pathway Regulation Of Nucleic Acid-templated Transcription System Development Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor Cellular Macromolecule Biosynthetic Process Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Central Nervous System Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Development Pattern Specification Process Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Activation Of Protein Kinase Activity Platelet Activation
Tagcloud ?		adjust bmal1 breeders circadian clock cry2 cryptochrome destroy deubiquitination erbalpha hydrocarbon hypothalamus kaput melatonin pars per1 per2 photoperiod pineal proteasome proteasomes rev rhythms scn suprachiasmatic translocator tuberalis widow	actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic
Tagcloud (Difference) ?		adjust bmal1 breeders circadian clock cry2 cryptochrome destroy deubiquitination erbalpha hydrocarbon hypothalamus kaput melatonin pars per1 per2 photoperiod pineal proteasome proteasomes rev rhythms scn suprachiasmatic translocator tuberalis widow	actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic
Tagcloud (Intersection) ?