CRY1 and TIMELESS

Number of citations of the paper that reports this interaction (PMID 10428031)
262

Data Source:
HPRD (in vivo)

		CRY1	TIMELESS
Gene Name		cryptochrome circadian clock 1	timeless circadian clock
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion	Nuclear Chromatin Nucleus Nucleolus Microtubule Cytoskeleton
	Molecular Function	Nucleotide Binding Transcription Factor Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding Core Promoter Binding DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Transcription Factor Binding Blue Light Photoreceptor Activity Protein Kinase Binding Phosphatase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Ubiquitin Binding	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gluconeogenesis DNA Repair Transcription, DNA-templated DNA Damage Induced Protein Phosphorylation Circadian Rhythm Blue Light Signaling Pathway Protein-chromophore Linkage Lipid Storage Negative Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of DNA Damage Checkpoint Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucocorticoid Secretion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Morphogenesis Of An Epithelium Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Circadian Rhythm Detection Of Abiotic Stimulus Response To Abiotic Stimulus Lung Development Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Cell Cycle Phase Transition Negative Regulation Of Transcription, DNA-templated Branching Morphogenesis Of An Epithelial Tube Cell Division
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		15 interactors: ARNTL CBLB CSNK1E GRN KRTAP4-12 LTBP4 MDFI PER1 PER2 PER3 PLSCR1 SNRPD3 TIMELESS TRAF2 USP2	9 interactors: CHEK1 CRY1 CRY2 PCBD1 PER1 PER2 TF TIPIN ZSCAN1
Entrez ID		1407	8914
HPRD ID		09050	04864
Ensembl ID		ENSG00000008405	ENSG00000111602
Uniprot IDs		A2I2P0 Q16526	Q9UNS1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Circadian Regulation Of Translation Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Response To Stimulus Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Hair Cycle Photoperiodism Entrainment Of Circadian Clock Regulation Of JNK Cascade Signal Transduction Cellular Response To Stimulus Cellular Metabolic Process Transcription, DNA-templated Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Transcription, DNA-templated Histone H3 Deacetylation Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Signaling Regulation Of RNA Metabolic Process Cell Communication Negative Regulation Of Signal Transduction Negative Regulation Of DNA Binding Regulation Of Protein Transport Negative Regulation Of Signaling Regulation Of Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Regulation Of Nitrogen Compound Metabolic Process	Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Response To Light Stimulus Photoperiodism Entrainment Of Circadian Clock Blue Light Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Radiation Circadian Rhythm Response To Blue Light Circadian Regulation Of Translation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process DNA Damage Induced Protein Phosphorylation Rhythmic Process Cellular Response To Light Stimulus Protein-chromophore Linkage Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Histone H3 Deacetylation RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gluconeogenesis Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Histone Deacetylation Hexose Biosynthetic Process Protein Deacetylation Histone Modification RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription, Termination
Tagcloud ?		adjust bmal1 breeders circadian clock cry2 cryptochrome destroy deubiquitination erbalpha hydrocarbon hypothalamus kaput melatonin pars per1 per2 photoperiod pineal proteasome proteasomes rev rhythms scn suprachiasmatic translocator tuberalis widow	ancestral anthropogenic arthropod calanus californicus circadian clock clockwork copepod copepods crustacean cryptochrome daphnia doubletime finmarchicus inputs intertidal orange pacemaker publicly pulex rhythms shaggy stressor stressors suite supernumerary tigriopus vrille
Tagcloud (Difference) ?		adjust bmal1 breeders cry2 destroy deubiquitination erbalpha hydrocarbon hypothalamus kaput melatonin pars per1 per2 photoperiod pineal proteasome proteasomes rev scn suprachiasmatic translocator tuberalis widow	ancestral anthropogenic arthropod calanus californicus clockwork copepod copepods crustacean daphnia doubletime finmarchicus inputs intertidal orange pacemaker publicly pulex shaggy stressor stressors suite supernumerary tigriopus vrille
Tagcloud (Intersection) ?		circadian clock cryptochrome rhythms