CRY1 and TIMELESS

Number of citations of the paper that reports this interaction (PubMedID 10428031)
0

Data Source:
HPRD (in vivo)

		CRY1	TIMELESS
Description		cryptochrome circadian regulator 1	timeless circadian regulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Chromatin Nucleus Nucleoplasm Chromosome Replication Fork Protection Complex Site Of Double-strand Break
	Molecular Function	Nucleotide Binding DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Photoreceptor Activity Blue Light Photoreceptor Activity Nuclear Receptor Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Histone Deacetylase Binding E-box Binding FAD Binding DNA-binding Transcription Factor Binding	DNA Binding Protein Binding Enzyme Activator Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of Gluconeogenesis Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Lipid Storage Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Signal Transduction In Response To DNA Damage Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of DNA Damage Checkpoint Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Glucocorticoid Secretion	DNA Replication Checkpoint Signaling Morphogenesis Of An Epithelium DNA Repair DNA Damage Response Circadian Rhythm Detection Of Abiotic Stimulus Lung Development Replication Fork Processing Regulation Of Cell Population Proliferation Regulation Of Circadian Rhythm Replication Fork Arrest Cell Cycle Phase Transition Negative Regulation Of DNA-templated Transcription Rhythmic Process Branching Morphogenesis Of An Epithelial Tube Cell Division Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Bleomycin Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins	Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Morning person ( 30696823) Suicide attempt severity in mood disorders ( 33783297)	Axial length ( 24144296) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Refractive error ( 32231278)
Interacting Genes		25 interacting genes: ARIH1 BHLHE41 BMAL1 CBLB CLOCK CSNK1E DELEC1 GRN KRTAP4-12 LTBP4 MDFI NPAS2 NR1D2 PER1 PER2 PER3 PLSCR1 PPP2R1B PPP2R5D PPP2R5E SNRPD3 TIMELESS TRAF2 USP2 USP7	12 interacting genes: CHEK1 CLSPN CRY1 CRY2 PCBD1 PER1 PER2 PLK1 TF TIPIN WEE2-AS1 ZSCAN1
Entrez ID		1407	8914
HPRD ID		09050	04864
Ensembl ID		ENSG00000008405	ENSG00000111602
Uniprot IDs		A2I2P0 Q16526	Q9UNS1
PDB IDs			4XHT 4XHU 4XHW 5MQI 6T9Q 6TAZ 7PFO 7PLO 8B9D
Enriched GO Terms of Interacting Partners?		Circadian Rhythm Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process Photoperiodism CLOCK-BMAL Transcription Complex Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Redox State E-box Binding Protein Phosphatase Type 2A Complex Negative Regulation Of RNA Metabolic Process Circadian Behavior Nucleoplasm Rhythmic Behavior Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Hair Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Phosphatase Regulator Activity Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Corepressor Binding Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Response To Light Stimulus Meiotic Sister Chromatid Cohesion Regulation Of RNA Metabolic Process Protein Dimerization Activity Negative Regulation Of Macromolecule Metabolic Process Chromatoid Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Membrane Raft Regulation Of Nucleobase-containing Compound Metabolic Process Protein Phosphatase Activator Activity Positive Regulation Of Circadian Rhythm Protein Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Response To Radiation Regulation Of Transcription By RNA Polymerase II Regulation Of Skeletal Muscle Cell Differentiation Transcription Cis-regulatory Region Binding	Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Signal Transduction In Response To DNA Damage Negative Regulation Of Circadian Rhythm Mitotic DNA Damage Checkpoint Signaling Circadian Regulation Of Gene Expression Mitotic DNA Integrity Checkpoint Signaling Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity DNA Damage Checkpoint Signaling Regulation Of Circadian Rhythm Cry-Per Complex Mitotic G2 DNA Damage Checkpoint Signaling Response To Light Stimulus Circadian Rhythm Negative Regulation Of Glucocorticoid Secretion Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Mitotic G2/M Transition Checkpoint DNA Damage Response Response To Blue Light Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Photoreceptor Activity Anaphase-promoting Complex Binding Rhythmic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Mitotic Nuclear Membrane Disassembly Negative Regulation Of Cell Cycle Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Kinase Binding Nuclear Membrane Disassembly Regulation Of G2/M Transition Of Mitotic Cell Cycle Membrane Disassembly Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of Metabolic Process DNA Replication Checkpoint Signaling Regulation Of Cell Cycle Process DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process
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