CRY1 and NR1D2

Number of citations of the paper that reports this interaction (PubMedID 23555304)
45

Data Source:
BioGRID (two hybrid)

		CRY1	NR1D2
Description		cryptochrome circadian regulator 1	nuclear receptor subfamily 1 group D member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Photoreceptor Activity Blue Light Photoreceptor Activity Nuclear Receptor Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Histone Deacetylase Binding E-box Binding FAD Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of Gluconeogenesis Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Lipid Storage Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Signal Transduction In Response To DNA Damage Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of DNA Damage Checkpoint Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Glucocorticoid Secretion	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Hormone-mediated Signaling Pathway Regulation Of Lipid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Circadian Behavior Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Lipid Homeostasis Energy Homeostasis Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins	Nuclear Receptor transcription pathway
Drugs			SR-9009 SR-9011
Diseases
GWAS		Morning person ( 30696823) Suicide attempt severity in mood disorders ( 33783297)	Acne (severe) ( 24927181) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Asthma ( 29273806) Cognitive ability ( 29186694) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483) Parkinson's disease progression (cognitive) ( 33111402) Refractive error ( 32231278)
Interacting Genes		25 interacting genes: ARIH1 BHLHE41 BMAL1 CBLB CLOCK CSNK1E DELEC1 GRN KRTAP4-12 LTBP4 MDFI NPAS2 NR1D2 PER1 PER2 PER3 PLSCR1 PPP2R1B PPP2R5D PPP2R5E SNRPD3 TIMELESS TRAF2 USP2 USP7	54 interacting genes: CRY1 CSNK1E CSNK2A2 CUL1 CYSRT1 DELEC1 EFEMP2 GTF2B HDAC1 HOXA1 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-6 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-8 LGALS8 MEOX2 MID2 MYLIP MYO15B NBPF19 NCOA5 NCOR1 NOTCH2NLA NR1D1 PCSK5 PRMT6 PROP1 RBPMS RGN RORC SIN3B TAF6 TAF9 TBC1D21 TENT5B TRIM27 TRIM55 TRIM63 TRIP6 TTC3 UBE2I ZNF587
Entrez ID		1407	9975
HPRD ID		09050	03809
Ensembl ID		ENSG00000008405	ENSG00000174738
Uniprot IDs		A2I2P0 Q16526	B4DXD3 F1D8P2 Q14995
PDB IDs			2V0V 2V7C 3CQV 4N73 6WMQ 6WMS
Enriched GO Terms of Interacting Partners?		Circadian Rhythm Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process Photoperiodism CLOCK-BMAL Transcription Complex Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Redox State E-box Binding Protein Phosphatase Type 2A Complex Negative Regulation Of RNA Metabolic Process Circadian Behavior Nucleoplasm Rhythmic Behavior Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Hair Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Phosphatase Regulator Activity Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Corepressor Binding Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Response To Light Stimulus Meiotic Sister Chromatid Cohesion Regulation Of RNA Metabolic Process Protein Dimerization Activity Negative Regulation Of Macromolecule Metabolic Process Chromatoid Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Membrane Raft Regulation Of Nucleobase-containing Compound Metabolic Process Protein Phosphatase Activator Activity Positive Regulation Of Circadian Rhythm Protein Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Response To Radiation Regulation Of Transcription By RNA Polymerase II Regulation Of Skeletal Muscle Cell Differentiation Transcription Cis-regulatory Region Binding	Intermediate Filament Keratin Filament Circadian Regulation Of Gene Expression Circadian Rhythm Negative Regulation Of Catabolic Process Nuclear Thyroid Hormone Receptor Binding Rhythmic Process Transcription Factor TFIID Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Circadian Rhythm RNA Polymerase II Preinitiation Complex Assembly Cytosol
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