GPS1 and COPS3

Number of citations of the paper that reports this interaction (PMID 11337588)
171

Data Source:
BioGRID (biochemical, affinity chromatography technology)
HPRD (in vitro, two hybrid)

		GPS1	COPS3
Gene Name		G protein pathway suppressor 1	COP9 signalosome subunit 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm COP9 Signalosome	Nucleus Nucleoplasm Cytoplasm COP9 Signalosome
	Molecular Function	GTPase Inhibitor Activity Protein Binding	Protein Binding
	Biological Process	Inactivation Of MAPK Activity Cell Cycle JNK Cascade Cullin Deneddylation	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus Cullin Deneddylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL1 CUL2 CUL3 CUL5 DDB1 IP6K1 ITPK1 JUN RBX1 SENP8 SKP1 SKP2 TBC1D17 TP53	20 interactors: ARAF CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL5 GPS1 IKBKB IKBKG ITGB2 JUN LRP2BP MLF1 RAF1 TP53
Entrez ID		2873	8533
HPRD ID		15991	07262
Ensembl ID		ENSG00000169727	ENSG00000141030
Uniprot IDs		C9JFE4 Q13098	Q9UNS2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Cullin Deneddylation Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Monoubiquitination Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Modification Process G1/S Transition Of Mitotic Cell Cycle Proteolysis Viral Process Cellular Macromolecule Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Arrest Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Catabolic Process Mitotic Cell Cycle Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Mitotic Cell Cycle Notch Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Circadian Rhythm Cell Cycle Process Negative Regulation Of Cell Proliferation Regulation Of Cell Proliferation Regulation Of DNA-templated Transcription In Response To Stress Response To Abiotic Stimulus Cell Communication Metabolic Process Negative Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Signal Transduction Histone H2A Monoubiquitination Cell Cycle Histone H2A Ubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Signaling	Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Apoptotic Process Response To External Stimulus Negative Regulation Of Programmed Cell Death Protein Metabolic Process Regulation Of Signaling Intracellular Signal Transduction Activation Of Innate Immune Response Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Cell Death Negative Regulation Of Cell Proliferation Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Phosphorylation Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway MAPK Cascade
Tagcloud ?		abnormal assigned calculated cop count css escc esophageal esophagectomy follows glasgow gps0 gps2 hypoalbuminemia indexes kaplan log lymphocyte meier neutrophil nlr nlr0 nlr1 nlr2 platelet predicts prognostic rank	arises arising bones ccnd1 cdk4 chromosomal chromosomes complement conventional cytogenetic decade demonstration derivative diploid homolog immunoreactivity loci locus malignancy mdm2 metaphysis monoallelic neoplastic neu osteosarcoma proximal rearrangements small tibia
Tagcloud (Difference) ?		abnormal assigned calculated cop count css escc esophageal esophagectomy follows glasgow gps0 gps2 hypoalbuminemia indexes kaplan log lymphocyte meier neutrophil nlr nlr0 nlr1 nlr2 platelet predicts prognostic rank	arises arising bones ccnd1 cdk4 chromosomal chromosomes complement conventional cytogenetic decade demonstration derivative diploid homolog immunoreactivity loci locus malignancy mdm2 metaphysis monoallelic neoplastic neu osteosarcoma proximal rearrangements small tibia
Tagcloud (Intersection) ?