GPS1 and ITPK1

Number of citations: 0 (PubMedID 12324474)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology), HPRD (in vitro, in vivo)

		GPS1	ITPK1
Name		G protein pathway suppressor 1	inositol-tetrakisphosphate 1-kinase
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome	Cytosol Apical Plasma Membrane
	Molecular Function	GTPase Inhibitor Activity Protein Binding	Nucleotide Binding Magnesium Ion Binding Inositol-1,3,4,5-tetrakisphosphate 6-kinase Activity Catalytic Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Isomerase Activity Metal Ion Binding Inositol-3,4,5,6-tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity Inositol-3,4,6-trisphosphate 1-kinase Activity
	Biological Process	Protein Deneddylation JNK Cascade Protein Neddylation Regulation Of Protein Neddylation	Signal Transduction Blood Coagulation Neural Tube Development Inositol Trisphosphate Metabolic Process Necroptotic Process
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle	Synthesis of pyrophosphates in the cytosol Synthesis of IP3 and IP4 in the cytosol Factors involved in megakaryocyte development and platelet production
GWAS		No GWAS studies recorded	Body mass index ( 26426971 ) Chronic obstructive pulmonary disease ( 30804561 ) Endometriosis ( 23472165 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Height ( 31562340 ) Migraine ( 27182965 27322543 ) Monocyte count ( 32888494 ) Platelet count ( 22139419 32888494 ) Plateletcrit ( 27863252 32888494 ) Spleen volume ( 34128465 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 ) White blood cell count ( 32888494 )
Interacting Genes		26 interacting genes: CNOT2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CUL1 CUL2 CUL3 CUL5 ELOB IP6K1 ITPK1 OGT RBX1 SAP130 SENP8 SKP1 SKP2 TBC1D17 TP53 TRIM55 TRIM63 VHL	6 interacting genes: COPS8 GPS1 JUN NFKBIA TP53 TRAF2
Entrez ID		2873	3705
HPRD ID		15991	03501
Ensembl ID		ENSG00000169727	ENSG00000100605
Uniprot IDs		A0A096LP07 A0A096LPJ3 A0A9L9PX62 A0A9L9PXT0 A8K070 C9JFE4 Q13098	G3V4M9 Q13572
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	2ODT 2Q7D 2QB5 9DN3
GO Terms Enriched among Interactors		Protein Deneddylation Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Neddylation Protein Modification Process Regulation Of Protein Neddylation Regulation Of Post-translational Protein Modification COP9 Signalosome Ubiquitin Ligase Complex Scaffold Activity Protein Modification By Small Protein Removal Cullin-RING Ubiquitin Ligase Complex Protein Metabolic Process Protein K48-linked Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Protein Ubiquitination Regulation Of Protein Modification Process Cytosol G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Proteolysis DeNEDDylase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Nucleus Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Macromolecule Catabolic Process Catabolic Process Cell Cycle Phase Transition Protein Polyubiquitination Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Cul5-RING Ubiquitin Ligase Complex Ubiquitin-protein Transferase Activity Protein Catabolic Process Cul2-RING Ubiquitin Ligase Complex Negative Regulation Of TORC1 Signaling Regulation Of TOR Signaling Positive Regulation Of Epithelial Cell Apoptotic Process Cytoplasm Intrinsic Apoptotic Signaling Pathway VCB Complex Negative Regulation Of TOR Signaling	Intracellular Signaling Cassette Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Ubiquitin Protein Ligase Binding Tumor Necrosis Factor-mediated Signaling Pathway Enzyme Binding Protein Deneddylation General Transcription Initiation Factor Binding Regulation Of Protein Neddylation Protein Neddylation Programmed Necrotic Cell Death Response To Muscle Stretch COP9 Signalosome Response To Endoplasmic Reticulum Stress Non-canonical NF-kappaB Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression Nucleoplasm Positive Regulation Of MiRNA Transcription JNK Cascade Transcription Repressor Complex Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Cytokine-mediated Signaling Pathway Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of MiRNA Transcription Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition TORC2 Complex Disassembly Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Primary Metabolic Process Protein Modification By Small Protein Removal Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Metabolic Process Leukocyte Activation Positive Regulation Of Apoptotic Process Leading Edge Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Oligodendrocyte Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Protein Import Into Nucleus Regulation Of Protein Modification Process