GPS1 and SENP8

Number of citations of the paper that reports this interaction (PMID 23408908)
4

Data Source:
BioGRID (far western blotting)

		GPS1	SENP8
Gene Name		G protein pathway suppressor 1	SUMO/sentrin specific peptidase family member 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm COP9 Signalosome	Nucleus Cytoplasm
	Molecular Function	GTPase Inhibitor Activity Protein Binding	NEDD8-specific Protease Activity
	Biological Process	Inactivation Of MAPK Activity Cell Cycle JNK Cascade Cullin Deneddylation	Protein Deneddylation Proteolysis
Pathways
Drugs
Diseases
GWAS			Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-Protein Interactions		20 interactors: COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL1 CUL2 CUL3 CUL5 DDB1 IP6K1 ITPK1 JUN RBX1 SENP8 SKP1 SKP2 TBC1D17 TP53	12 interactors: COPS2 CUL1 CUL2 CUL4A GPS1 NEDD8 PLA2G2A SMURF1 UBB USP15 USP21 USP28
Entrez ID		2873	123228
HPRD ID		15991	09784
Ensembl ID		ENSG00000169727	ENSG00000166192
Uniprot IDs		C9JFE4 Q13098	A8K8D3 Q96LD8
PDB IDs			1XT9 2BKQ 2BKR
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Cullin Deneddylation Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Monoubiquitination Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Modification Process G1/S Transition Of Mitotic Cell Cycle Proteolysis Viral Process Cellular Macromolecule Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Arrest Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Catabolic Process Mitotic Cell Cycle Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Mitotic Cell Cycle Notch Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Circadian Rhythm Cell Cycle Process Negative Regulation Of Cell Proliferation Regulation Of Cell Proliferation Regulation Of DNA-templated Transcription In Response To Stress Response To Abiotic Stimulus Cell Communication Metabolic Process Negative Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Signal Transduction Histone H2A Monoubiquitination Cell Cycle Histone H2A Ubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Signaling	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Catabolic Process Protein Modification By Small Protein Removal Cellular Protein Modification Process Proteolysis Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cullin Deneddylation Regulation Of Proteolysis Signal Transduction Protein Deneddylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cell Cycle Signaling Regulation Of Metabolic Process Cell Communication Regulation Of Protein Metabolic Process Cellular Metabolic Process Histone Deubiquitination Cell Cycle Arrest Negative Regulation Of Cell Cycle Response To Stimulus Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Programmed Cell Death Cell Cycle Process
Tagcloud ?		abnormal assigned calculated cop count css escc esophageal esophagectomy follows glasgow gps0 gps2 hypoalbuminemia indexes kaplan log lymphocyte meier neutrophil nlr nlr0 nlr1 nlr2 platelet predicts prognostic rank	attributed bca3 bind conversely crucial cullins deacetylase du145 link mcf7 modification nad necrosis nedd8 neddylated neddylation nfkappab p65 prolongs protease recruit reversed silencing sirt1 span substrates ubiquitin worms yeast
Tagcloud (Difference) ?		abnormal assigned calculated cop count css escc esophageal esophagectomy follows glasgow gps0 gps2 hypoalbuminemia indexes kaplan log lymphocyte meier neutrophil nlr nlr0 nlr1 nlr2 platelet predicts prognostic rank	attributed bca3 bind conversely crucial cullins deacetylase du145 link mcf7 modification nad necrosis nedd8 neddylated neddylation nfkappab p65 prolongs protease recruit reversed silencing sirt1 span substrates ubiquitin worms yeast
Tagcloud (Intersection) ?