GPS1 and COPS4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, affinity chromatography technology, biochemical)

		GPS1	COPS4
Description		G protein pathway suppressor 1	COP9 signalosome subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome	Nucleus Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle COP9 Signalosome Nuclear Speck Cell Junction Cytoplasmic Vesicle Protein-containing Complex Synapse
	Molecular Function	GTPase Inhibitor Activity Protein Binding	Protein Binding DeNEDDylase Activity
	Biological Process	Protein Deneddylation JNK Cascade Protein Neddylation Regulation Of Protein Neddylation	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS			Metabolite levels ( 23823483)
Interacting Genes		26 interacting genes: CNOT2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CUL1 CUL2 CUL3 CUL5 ELOB IP6K1 ITPK1 OGT RBX1 SAP130 SENP8 SKP1 SKP2 TBC1D17 TP53 TRIM55 TRIM63 VHL	28 interacting genes: BRME1 CCDC85B CEBPA COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL5 DSCR9 FOS GPS1 HUNK IKBKB IL1RN KRT19 LCOR MBIP PCDHB12 PEX14 RAB18 RBX1 RCBTB2 TP53 UBQLN1 USHBP1 YWHAQ
Entrez ID		2873	51138
HPRD ID		15991	09888
Ensembl ID		ENSG00000169727	ENSG00000138663
Uniprot IDs		A0A096LP07 A0A096LPJ3 A0A9L9PX62 A0A9L9PXT0 A8K070 C9JFE4 Q13098	A0A0S2Z5H7 B3KM48 D6RAX7 Q9BT78
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	4D0P 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Neddylation Protein Modification Process Regulation Of Protein Neddylation Regulation Of Post-translational Protein Modification COP9 Signalosome Ubiquitin Ligase Complex Scaffold Activity Protein Modification By Small Protein Removal Cullin-RING Ubiquitin Ligase Complex Protein Metabolic Process Protein K48-linked Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Protein Ubiquitination Regulation Of Protein Modification Process Cytosol G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Proteolysis DeNEDDylase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Nucleus Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Macromolecule Catabolic Process Catabolic Process Cell Cycle Phase Transition Protein Polyubiquitination Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Cul5-RING Ubiquitin Ligase Complex Ubiquitin-protein Transferase Activity Protein Catabolic Process Cul2-RING Ubiquitin Ligase Complex Negative Regulation Of TORC1 Signaling Regulation Of TOR Signaling Positive Regulation Of Epithelial Cell Apoptotic Process Cytoplasm Intrinsic Apoptotic Signaling Pathway VCB Complex Negative Regulation Of TOR Signaling	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation COP9 Signalosome Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process COP9 Signalosome Assembly Protein Modification Process Intracellular Signaling Cassette Cytosol Regulation Of Primary Metabolic Process Negative Regulation Of Mitophagy Metal-dependent Deubiquitinase Activity Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cul5-RING Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleoplasm Cytokine-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor DNA-templated Transcription Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Stem Cell Proliferation Nucleus Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of RNA Metabolic Process Histone Deacetylase Binding Nuclear Matrix Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Metabolic Process Response To Glucocorticoid Cellular Response To Hypoxia Medium-term Memory Cellular Response To Prolactin Protein Metabolic Process Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity Peroxisome Transport Along Microtubule
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